Structural and sequence information facilitates recombination
Poliovirus Polymerase Leu420 Facilitates RNA Recombination and Ribavirin Resistance
... RNA recombination is underpinned by the atomic structure of 3D pol elongation complexes (28, 29) and a series of genetically stable alanine substitution mutations in 3D pol ...RNA recombination. We discuss ...
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Structural Variation Shapes the Landscape of Recombination in Mouse
... independent random draws from the population. The ex- pected frequency of a CO between a given pair of founder haplotypes is equal to the product of the marginal frequency of those haplotypes. Our information ...
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Exploring Protein Sequence Space Using Computationally Directed Recombination
... protein sequence space is mutagenesis. However, recombination of homologous genes can also explore regions of sequence space rich with folded and functional ...protein sequence and structure ...
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Optimizing the Nucleotide Sequence of a Meiotic Recombination Hotspot in Schizosaccharomyces pombe
... this sequence and activates ...consensus sequence for Atf1-Pcr1 binding, 5⬘-GNVTATGACGTCATNBNC- 3⬘, containing the M26 heptamer at its ...consensus sequence as a guide, we made mutations on each side ...
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Important Characteristics of Sequence-Specific Recombination Hotspots in Schizosaccharomyces pombe
... M EIOSIS is an essential process in the life cycle of sexually reproducing organisms. It differs from mitosis in that two successive cell divisions follow a single round of chromosome replication, resulting in the ...
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Joint analysis of sequence data and single nucleotide polymorphism data using pedigree information for imputation and recombination inference
... from sequence data will improve, which in turn will improve our imputation results ...consider information within families and information at the popula- tion level will be our future ...observed ...
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HemeBIND: A Novel Method for Heme Binding Residue Prediction by Combining Structural and Sequence Information
... integrating structural and sequence ...several sequence and structural attributes such as evolutionary conservation, solvent accessibility, depth and protrusion clearly illustrate the ...
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Expresso: automatic incorporation of structural information in multiple sequence alignments using 3D-Coffee
... The reason why structure-based MSAs are more accurate is not so much a consequence of better algorithms but rather an effect of structures evolutionary stability. Structures evolve slower than the sequences (4) and even ...
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Structural approaches to protein sequence analysis
... day sequence with its own immediate predecessor and thus accurately map the evolutionary history of each sequence ...ancestral sequence is the most probable for the tree as a ...
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Integrating sequence and structural biology with DAS
... Discussion DAS is an important system for exchanging and viewing biological data. The simple, but powerful original design of the DAS specification allowed scope for extension of the protocol. Here we presented several ...
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A High-Density Genetic Recombination Map of Sequence-Tagged Sites for Sorghum, as a Framework for Comparative Structural and Evolutionary Genomics of Tropical Grains and Grasses
... genetic recombination map for Sorghum of 2512 loci spaced at average ...the recombination events in this progeny set and reveal strong positive crossover interference acting across intervals of ⱕ50 ...
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Evidence of structural genomic region recombination in Hepatitis C virus
... In order to confirm these results, the same sequences were used for a bootscanning study. The basic principle of bootscanning is that mosaicism is suggested when one observes high levels of phylogenetic relatedness ...
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MUMMALS: multiple sequence alignment improved by using hidden Markov models with local structural information
... HOMSTRAD structural alignments (11,34) with various numbers of homologs added (Supplementary Table ...some sequence subgroups in ‘HOM + 100’ test cases, since our consistency measure does not take into ...
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Recombination and large structural variations shape interspecific edible bananas genomes
... NGS sequence data to characterize the A versus B chromosome composition of nine diploid and triploid interspecific cultivars, to compare the chromosome structures of A and B genomes and analyze A/B chromosome ...
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Sequence Information. Sequence information. Good web sites. Sequence information. Sequence. Sequence
... Linköping University & Karolinska Institutet 2 Sequence information Sequence Comparisons Pair-wise Multiple Database searches SRS Entrez Protein families Patterns Post-translational [r] ...
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C1 Inhibitor Gene Sequence Facilitates Frameshift Mutations
... Because this is such a rare event, as judged by the reversion rate, we were unable to identify successive repeats where the inverted repeat caused cycled tandem duplicati[r] ...
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The Detection and Measurement of Recombination From Sequence Data
... demonstrate recombination from Figure 1A shows Sawyer’s ratio, a measure based on population data in Plasmodium ...frequent recombination, a test based on the occurrence D 5 1 will occur by chance, even ...
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Herpes simplex virus type 1 variant a sequence generated by recombination and breakage of the a sequence in defined regions, including the one involved in recombination.
... Almost all termini of the cloned unusual DNA fragments were situated in defined regions assumed to be recombinogenic: (i) a site in the inverted repeat of the L component, (ii) DR1, (iii[r] ...
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DNA Sequence Similarity Requirements for Interspecific Recombination in Bacillus
... homologous recombination decreases sharply with the level of relatedness between the donor and ...DNA sequence divergence between recombining ...of sequence identity to initiate strand ...donor ...
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Retrovirus recombination depends on the length of sequence identity and is not error prone.
... contained two MoMuLV LTRs and a neo gene between the two LTRs. They also contained sequences from the chimeric RNA vector JZ211. The lightly striped boxes represent the neo gene, and the[r] ...
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