Synaptic function
Altered hippocampus synaptic function in selenoprotein P deficient mice
... motor function and memory formation [16,25], but these observation may be a result of neuronal cell death in the ...to synaptic function beyond selenium delivery ...cerebellar function is ...
13
DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze
... basal synaptic transmission and hippocampal long-term potentiation are impaired in ROCK2-deficient mice ...properties, synaptic density, and actin cytoskeletal devel- opment while these mutant mice are ...
11
Myostatin like proteins regulate synaptic function and neuronal morphology
... and/or synaptic physiology is mediated via reduced MYO synthesis and secretion, then extracellular injection of myostatin should reverse these effects in 3rd instar wandering stage ...on synaptic ...
12
ApoE isoform-dependent changes in hippocampal synaptic function
... Essential to defining how apoE influences the memory disruption and etiology of neurodegenerative disorders such as Alzheimer's disease is the establishment of the role of apoE in synaptic function. ...
18
Restoration of synaptic function in sight for degenerative retinal disease
... Although synaptic plasticity is critical for learning and memory, it is unclear whether this innate property helps restore synaptic function in disease once the primary cause of disease is ...
5
Role of BACE1 in Alzheimer’s synaptic function
... aberrant synaptic transmission. Astrocytes regulate synaptic function and plasticity in close association with synapses ...synapse function and ...impact synaptic functions due to an ...
8
Consumption of pomegranates improves synaptic function in a transgenic mice model of Alzheimer’s disease
... in synaptic plasticity underlying cognitive ...and synaptic plasticity in APPsw/Tg2576 mice ...of synaptic structure proteins, namely PSD-95, Munc18-1, and SNAP25, synaptophysin, phosphorylation of ...
16
Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease
... and function of synapses [15] and alteration in their levels could underlie synaptic dysfunction in pathological states ...neuronal function such as glutamate receptors [17 – ...protein ...
11
Acid-sensing ion channels: trafficking and synaptic function
... the synaptic localization of ASICs, and indicate that ASIC activation affects synaptic ...to synaptic transmission, either in physiological or pathophysiological ...during synaptic ...
13
Gangliosides and anti-ganglioside antibodies in neuromuscular synaptic function
... 153 shown in several functional studies (Santafé et al., 2008; Buchwald et al., 2007; Nakatani et al., 2007b; Nakatani et al., 2009; Buchwald et al., 2002; Ortiz et al., 2001; Roberts et al., 1994; Plomp et al., 1999; ...
190
Huatuo Zaizao pill ameliorates cognitive impairment of APP/PS1 transgenic mice by improving synaptic plasticity and reducing Aβ deposition
... reducing the pathologic damage of Alzheimer’s disease (AD) [45, 46]. It has been observed that both ADAM10 localization and its activity are reduced in synapses in the brains of AD patients, especially in hippocampus. ...
13
Original Article Abnormal glutamate release in aged BTBR mouse model of autism
... are synaptic scaffold pro- teins at the postsynaptic density (PSD) of excit- atory ...for synaptic function in spine morphogenesis and synaptic plasticity ...
9
Encephalitis associated with autoantibody binding to the anti-N-methyl-D-aspartate receptor: immunopathogenesis, mechanisms, and clinical characteristics
... synaptic function may explain the clinical symptoms of patients with this encephalopathy, who initially present with behavioral or cognitive dysfunction with or without seizure, fol[r] ...
7
Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits
... and synaptic function in adulthood [24, ...of synaptic function and plasticity in neocortex and hippocampus are related to cellular and behavioral alterations observed in neuro- psychiatric ...
13
Evolution of Molecular Function in Mammalian Neurons
... as synaptic plasticity, is fundamental for learning and ...of synaptic plasticity involves delivering mRNA to distinct domains where they are locally ...and synaptic plasticity as defects in these ...
251
Tweet
... crucial function of MMP-3 in synaptic plasticity, learning, neuronal development, as well as in ...in synaptic long-term potentiation, which is likely to have a profound impact on experience- ...
6
Extraction of synaptic input properties in vivo
... the synaptic input parameters across 8 recordings displaying an increase in the input frequency during movement but not in the mean or variance of the event ...the synaptic event amplitude ...
20
Disruption of a structurally important extracellular element in the Glycine Receptor leads to decreased synaptic integration and signaling resulting in Severe Startle Disease
... (Grudzinska et al., 2005). Disturbances in glycinergic inhibition are associated with rare disorders such as startle disease (OMIM 149400, hyperekplexia, stiff baby syndrome) and autism spec- trum disorders (Harvey et ...
15
Sex differences in brain plasticity: a new hypothesis for sex ratio bias in autism
... SP: synaptic plasticity; T: testosterone; TBI: traumatic brain injury; TD: typically developing; TTT: trigger-threshold-target; VPA: valproic acid; WES: whole exome ...
19
Angelman syndrome: advancing the research frontier of neurodevelopmental disorders
... gantly described how he and Stormy Chamberlain are using induced pluripotent stem (iPS) cells to develop an innova- tive approach to study AS. Their lab has established two human AS deletion and two normal control iPS ...
7