T cell activation
T cell activation without proliferation in juvenile idiopathic arthritis
... early activation marker (CD69) and the transferrin receptor (CD71) in our study has added an extra dimension to the understanding of the process of ...Antigen-induced T-cell activation in ...
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Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming
... immune cell cytotoxicity and population change have been well studied in human and animal models, little is known about the functional alterations of the surviving immune cells after ionizing ...on T ...
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Fc γ receptors and the complement system in T cell activation
... + T cells directly in vivo, wild-type and CD11c-DTR transgenic mice were injected with CFSE-labelled OVA-specific CD4 + T cells and immunized with ...induces T-cell prolifer- ation in both ...
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Critical roles of Bim in T cell activation and T cell–mediated autoimmune inflammation in mice
... B cell lymphoma 2–interacting (Bcl2-interacting) mediator, maintains immunological tolerance by deleting autoreactive lymphocytes through ...the activation of autoreactive T ...Bim-deficient T ...
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T Cell activation: a queuing theory analysis at low agonist density
... that T-cell activation is not achieved in a single step or commitment event, but is a multistep sequence of events in which disruption of signaling proportionally reduces activa- tion ...studies, ...
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Downregulation of the T-Cell Receptor Complex and Impairment of T-Cell Activation by Human Herpesvirus 6 U24 Protein
... ⫹ T cells, and further study of the role of U24 in roseolavirus infection is ...downregulate cell surface B-cell receptor BCR expression by blocking its transport to the cell surface ...with ...
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Effects of Prostratin on T-Cell Activation and Human Immunodeficiency Virus Latency
... infected cell either by immune-mediated mechanisms or by direct viral cy- topathic effects while at the same time preventing de novo infection of additional T ...full activation of these cells and ...
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T cell activation promotes tumorigenesis in inflammation associated cancer
... towards T lym- phocytes, is also known to activate the granzyme B pro- ...target T cell activation in the liver ...and T cell activation in TAX-LUC mice were sufficient to ...
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Mutation of a diacidic motif in SIV PBj Nef impairs T cell activation and enteropathic disease
... immune activation is regarded as a hallmark of pathogenic SIV and HIV infec- tions during the chronic phase of infection ...cause T cell activation and cellular proliferation on the induc- ...
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HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation
... partial activation of membrane-proximal signals that began with Lck phosphorylation ...Lck activation in the Env-containing TCR-in- duced immunological ...CD4 T cell activation, as ...
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CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation
... the T cell exhaustion we detected in our ...3) T cells when co-cultured with MDA MB 468 breast cancer cells in the presence of IL4 (400 U/mL) ...1G T cells failed to expand and control tumors; ...
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T cell-activation in neuromyelitis optica lesions plays a role in their formation
... antigen-specific T cells can cross through the brain capillary endothelium, open the blood–brain barrier for the subsequent entry of additional inflammatory mediators, and initiate inflammatory CNS ...
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In vivo analysis of Nef’s role in HIV 1 replication, systemic T cell activation and CD4+ T cell loss
... relatively high in bone marrow, lung and liver and these cells are lost with JRCSF infection [27]. It is not known if the cytotoxic effect of JRCSF in these organs is indirect through systemic T cell ...
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A global transcriptional view of apoptosis in human T-cell activation
... in T- cell activation remain largely ...in T-cell activation without discussion ...(myeloid cell leukemia sequence 1) (anti- apoptotic), BMF (BCL2 modifying factor) ...
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Modulation of HIV-1 replication and T cell activation by FoxP3
... human T cells were maintained in Iscoves MEM, supplemented with 10% FBS (Sigma), 2mM L-glutamine, 100 U/ml penicillin, and 100P mg/ml ...For T cell activation, mouse anti-CD3 and CD28 (BD ...
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Modelling T cell activation
... cytoskeleton. Activation of the PI pathway results in release of Ca^+ from intracellular stores and this drives the translocation of cytoplasmic nuclear factor of activated T cells (NFAT) into the nucleus, ...
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2 photon imaging of phagocyte mediated T cell activation in the CNS
... T cell/APC contacts are crucial for T cell ...the T cells correlated with their contacts to local APCs (Figure 5A and Supplemental Video ...of T cell antigen specificity ...
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TLR dependent T cell activation in autoimmunity
... naïve T cells, but also by providing the cytokine stimulus (the third signal) for T cell activation 1-2 ...of T cell-promoting cytokines 1 , using distinct signaling pathways ...
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CD4+CD25+ T cells maintain homeostasis by promoting TER-119 cell development and inhibiting T cell activation
... development of autoreactive cells [1-5]. CD4 is a coreceptor molecule on T cells and it also expressed in limited population of macrophages. CD4 molecule is also known to become MHC class II ligand. On the other ...
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Important Functional Roles of Basigin in Thymocyte Development and T cell Activation
... ti-CD3-induced T lymphocyte activation, presumably via the inhibition of the reorganization and clustering of GPI-anchored co-receptors within lipid rafts, which, in turn, altered downstream signaling ...
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