T-cell leukemia
Molecular biology of the type I human T cell leukemia virus (HTLV I) and adult T cell leukemia
... Abbreviations used in this paper: ATF, activating transcription factor; ATLL, adult T-cell leukemia/lymphoma; CREB, cyclic ANMP response element binding protein; HTLV-I, type I human T-c[r] ...
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Multidisciplinary insight into clonal expansion of HTLV-1–infected cells in adult T-cell leukemia via modeling by deterministic finite automata coupled with high-throughput sequencing
... Adult T-cell leukemia (ATL) is a life-threatening malig- nancy that manifests with very poor prognosis [11, ...human T-cell leukemia virus type-1 (HTLV-1), which is mainly ...
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Superoxide-Generating Nox5α Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype
... uman T-cell leukemia virus type 1 (HTLV-1) is the first hu- man oncogenic retrovirus shown to be etiologically associ- ated with adult T-cell leukemia (ATL) (1, ...blood T ...
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Functional and phenotypic comparison of human T cell leukemia/lymphoma virus positive adult T cell leukemia with human T cell leukemia/lymphoma virus negative Sézary leukemia, and their distinction using anti Tac Monoclonal antibody identifying the human receptor for T cell growth factor
... similar cell morphology and clinical ...(human T cell leukemia/lymphoma virus), a unique human type C retrovirus, whereas most patients with the Sézary syndrome do not have antibodies to this ...
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Adult t cell leukemia/ lymphoma: from epidemiology to treatment
... (Human T cell leukemia / lymphoma virus type 1), an exogenous retrovirus discovered in humans, isolated in the United States, in ...+ T cells. These cells came from the peripheral blood of a ...
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Prevention of Adult T-Cell Leukemia-Like Lymphoproliferative Disease in Rats by Adoptively Transferred T Cells from a Donor Immunized with Human T-Cell Leukemia Virus Type 1 Tax-Coding DNA Vaccine
... Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) in infected individuals after a long incubation ...immune T cells on the development of the ...
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Mogamulizumab for the treatment of adult T-cell leukemia/lymphoma
... Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell lymphoma caused by latent infection of human T-cell lymphotropic virus type ...stem cell ...
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Human T cell leukemia virus type I (HTLV I) infection and the onset of adult T cell leukemia (ATL)
... as T-lym- phocytes, B-lymphocytes, monocytes and fibroblasts ...on cell surfaces ...CD8-positive T-lymphocytes ...CD4-positive T-lymphocytes in vivo by enhanced proliferation and suppressed ...
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Inhibition of constitutively active Jak Stat pathway suppresses cell growth of human T cell leukemia virus type 1 infected T cell lines and primary adult T cell leukemia cells
... infected T-cell ...(+)] T-cell ...HTLV-1-infected T-cell lines were detected by EMSA using SIE or β-casein ...HTLV-1-infected cell lines using 100-fold excess of unlabeled ...
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Oncogenic progression in retrovirus-induced T-cell leukemia
... Induction of leukemia in mice using a radiation leukemia virus-induced cell line: a model system for studying oncogenic progression... flanking genomic DNA: association with regions of r[r] ...
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Complete Bovine Leukemia Virus (BLV) Provirus Is Conserved in BLV-Infected Cattle throughout the Course of B-Cell Lymphosarcoma Development
... human T-cell leukemia virus types 1 and 2 (HTLV-1 and -2), agents associated with adult T-cell leukemia (ATL) and with the chronic neurological disorder tropical spastic ...
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Dimerization and a Novel Tax Speckled Structure Localization Signal Are Required for Tax Nuclear Localization
... human T-cell leukemia virus type 1 oncoprotein Tax has pleiotropic activities, a subset of which likely leads to immortalization of T ...the cell nucleus and the ...
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HTLV 1 infection of myeloid cells: from transmission to immune alterations
... Human T-cell leukemia virus type 1; ATLL: adult T-cell leukemia/lym- phoma; HAM/TSP: HTLV-1-associated myelopathy/tropical spastic paraparesis; ACs: asymptomatic carriers; PVL: ...
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T cell receptor-engineered T cells for leukemia immunotherapy
... of leukemia patients [11] or from healthy donor T cells induced by LSA or LAA peptides with major histo- compatibility complex (MHC) ...loid leukemia cells, including acute myelocytic leuke- mia ...
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T-cell Prolymphocytic Leukemia.
... post-thymic T-cell malignancies) and only a minority of cases express a CD4-/CD8+ ...distinguish T-PLL from adult T-cell leukemia (ATL) and SS. T-PLL patients are also ...
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Severe Diarrhea Due To Cystoisospora belli Infection in an HTLV-1 Woman
... cyte counts (usually < 200 cells/μl) (1, 2). Human T-lymphotropic Virus Type I or HTLV-1 is a human RNA retrovirus known to cause adult T-cell leukemia. It is a kind of lym- phoma which is ...
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Detection of human T cell lymphotropic virus type I proviral DNA and its gene expression in synovial cells in chronic inflammatory arthropathy
... associated chronic inflammatory arthropathy (HAAP), we sought to detect proviral DNA in the articular lesions. For the detection of proviral DNA, we used the polymerase chain reaction (PCR). Proviral DNA was detected not ...
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Immunotherapy in hematologic malignancies: past, present, and future
... cytotoxic T- lymphocyte-associated protein 4 (CTLA-4) and pro- grammed-death 1 (PD-1) as a mechanism of immune es- cape, immune checkpoint blockade was developed as a therapeutic strategy that has been shown to be ...
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T cell receptor alpha , beta , and gamma genes in T cell and pre B cell acute lymphoblastic leukemia
... most T-ALLs (22/26) were of sufficient maturity to have rearranged both ...genes. T- ALLs preferentially rearranged C gamma 2 versus the C gamma 1 complex; no preference within the beta locus was ...
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MYC as therapeutic target in leukemia and lymphoma
... studies and mouse transgenic models have shown that MYC plays a pivotal role in initiation and development of many types of hematological neoplasms. Thus, MYC would be a good therapeutic target in leukemia and ...
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