telomerase RNA (TR)
Identification of the Telomerase RNA in the Filamentous Fungus Aspergillus oryzae
... called telomerase. The protein component of telomerase (TERT) utilizes an RNA template sequence (TR) to reverse transcribe nucleotides onto the 3’ end of the ...the TR varies greatly in ...
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The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells
... The telomerase holoenzyme is composed of a number of proteins involved in the assembly, processing and stability of the complex in vivo [reviewed in 5, ...the RNA component (telomerase RNA, ...
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Structure of the Tetrahymena thermophila telomerase RNA helix II template boundary element
... by telomerase requires an internal templating sequence located in the RNA subunit of ...ble RNA and/or protein interactions for the helix II loop within the Tetrahymena telomerase ...
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Structure and function of Tetrahymena thermophila telomerase RNA
... yeast telomerase RNA secondary structure was independently proposed by four different research groups (Chappell and Lundblad 2004; Dandjinou et ...utilized RNA folding programs combined with ...
165
Targeting Human Telomerase RNA via Biochemical and in vitro Selection Methods
... the RNA-RNA interaction, as evidenced by the stem mutant data, altering the ...the RNA-RNA ...mammalian telomerase RNA reduces telomerase activity, suggesting that ...
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Clinical significance of combined detection of human papilloma virus infection and human telomerase RNA component gene amplification in patients with squamous cell carcinoma of the esophagus in northern China
... human telomerase RNA component (hTERC) gene may influence the inte- gration of HPV into the cellular genome, accumulation of numerical chromosome aberrations and development of genomic instability with a ...
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Medaka tert produces multiple variants with differential expression during differentiation in vitro and in vivo
... the telomerase RNA (TR) subunit that contains a template region com- plementary to the telomeric sequence for reverse transcription ...with telomerase activity [15], whereas TR is ...
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Human telomerase RNA component (hTERC) gene amplification detected by FISH in precancerous lesions and carcinoma of the larynx
... Human telomerase reverse transcriptase (hTERT) mRNA increases progres- sively with the degree of laryngeal epithelial abnormal- ...that telomerase reactivation is an early event in laryngeal carcinogenesis, ...
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Expression and biological-clinical significance of hTR, hTERT and CKS2 in washing fluids of patients with bladder cancer
... human telomerase RNA (hTR), human telomerase reverse transcriptase (hTERT) and CDC28 protein kinase regulatory subunit 2 (CKS2) in bladder carcinogenesis and their possible clinical significance; ...
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The RNA Subunit of Telomerase Is Encoded by Marek's Disease Virus
... The high degree of similarity between the primary sequences of vTR and cTR genes was also reflected in their overall secondary structures (Fig. 4A). However, most of the muta- tions and deletions scattered along the vTR ...
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5587.pdf
... However, telomerase RNAs identified to date harbor more than one telomere repeat of complementary sequence, which allows for primer ...promote telomerase processivity, where one telomere is elongated for ...
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Tetrahymena Mutants With Short Telomeres
... tgi1-1 telomerase RNA causes telomere shorten- ing: To determine whether the tgi1-1 telomerase RNA mutation was responsible for the tgi phenotype, we in- troduced the mutant gene into ...
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Expression Pattern of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase (hTERT) in Cancer Cell Lines Was not Associated with the Origin of the Cells
... called telomerase to solve this ...active telomerase adds up some nonfunctional DNA repeats to the telomeric ends, to keep the critical length of DNA during multiple cell divisions ...of telomerase ...
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Abnormal Micronuclear Telomeres Lead to an Unusual Cell Cycle Checkpoint and Defects in Tetrahymena Oral Morphogenesis
... the telomerase RNA and consequently the telomeric DNA itself (40) or by depleting a protein that binds the telomeres ...the telomerase RNA template such that it synthesizes a combination of ...
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Identifying cancer-causing noncoding RNAs
... than telomerase activity or hTERT expression (Brown et ...erase RNA levels did not parallel the amount of telomerase activity detected (Blasco et ...lacked telomerase activity, ...
136
Dynamics of Telomeric DNA Turnover in Yeast
... its RNA subunit as a ...lactis telomerase RNA gene (TER1) tem- ...by telomerase but that there are other processes that also contribute to ...
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The Est1 Subunit of Saccharomyces cerevisiae Telomerase Makes Multiple Contributions to Telomere Length Maintenance
... the telomerase RNA. (A) Plasmids expressing A previously proposed RNA recognition motif in Est1 either the tagged Est1-myc 18 protein or the untagged Est1 is not required for association with ...
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TR 124 pdf
... WAN.BRIDGE. 3 If bridge mode is enabled on the device by default for LAN connected devices, the device MUST be able to support additional connections for TR-069 remote management addressability (using direct DHCP ...
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Heregulin, a new regulator of telomere length in human cells
... According to the “protein-counting” model [28- 31, 61], HRGβ2-promoted very short telomeres might not bind sufficient amounts of TRF2 to create a “closed state” at the telomere [28-31, 61, 62]. At this stage, telomere ...
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Dual RNA seq of Nontypeable Haemophilus influenzae and Host Cell Transcriptomes Reveals Novel Insights into Host Pathogen Cross Talk
... ABSTRACT The ability to adhere and adapt to the human respiratory tract mucosa plays a pivotal role in the pathogenic lifestyle of nontypeable Haemophilus influenzae (NTHi). However, the temporal events associated with a ...
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