The cAMP response element-binding protein (CREB)
Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice
... co-activators, cAMP-response element-binding protein (CREB)-binding protein (CBP) ( Takemaru and Moon, 2000 ) or EP300 (p300) ( Hecht et ...the binding between ...
8
European Journal of Endocrinology (2003) ISSN EXPERIMENTAL STUDY Expression of camp response element-binding protein and sodium
... factor cAMP response element- binding protein (CREB) belongs to the basic domain/ leucine zipper class of proteins, which bind to CRE ...by protein kinase A (PKA), whereas ...
8
Adenosine A2Breceptors induce proliferation, invasion and activation of cAMP response element binding protein (CREB) in trophoblast cells
... of cAMP response element-binding protein in the regulation of cell proliferation and the prolactin promoter of lactotrophs in primary ...
9
Inhibition of cAMP response element-binding protein reduces neuronal excitability and plasticity, and triggers neurodegeneration
... For Peer Review been shown that CREB/CREB-M1 heterodimers can still exhibit significant transactivation capability (Loriaux et al., 1993). K-CREB, the point mutant (R287L) used by Pittenger and colleagues (Pittenger et ...
56
Cytokine-mediated Down-regulation of the Transcription Factor camp-response Element-binding Protein in Pancreatic -Cells*
... -cell line, MIN6 cells, to cytokines (interleukin-1, tu- mor necrosis factor- ␣, and interferon-␥) led to a signifi- cant (p < 0.01) decrease in Bcl-2 protein and mRNA levels. Cytokines decreased (56%) the ...
11
Expression of the Nuclear Receptor Coactivator, cAMP Response Element-Binding Protein, Is Sexually Dimorphic and Modulates Sexual Differentiation of Neonatal Rat Brain
... Indeed, simultaneous reduction of both CBP and SRC-1 was required to interfere with adult female sexual behavior and estradiol induction of progestin receptors (9). It is important to note that CBP is not only a ...
10
Insulin-like Growth Factor-I Induces bcl-2 Promoter through the Transcription Factor camp-response Element-binding Protein*
... by protein kinase A, protein kinase C, Ca 21 , Ras, and phosphatidylinositol ...sonication. Protein samples were separated by SDS-PAGE and immunoblotted for ...
7
Chronic GnRH Inhibits Activin Induction of the ovine FSH Beta Subunit: Involvement of cAMP Response Element Binding Protein (CREB) and Nitric Oxide Synthase typeI (NOSI)
... Here we examined the mechanism by which GnRH inhibits activin-induced expression of FSHβ and provide evidence that implicates activation of CREB and/or NOSI via cAMP or PKC signaling pathways. We showed that ...
130
Ghrelin through GHSR1a and OX1R heterodimers reveals a Gαs–cAMP cAMP response element binding protein signaling pathway in vitro
... s/cAMP/cAMP-response element signaling pathway upon co-expression of the two .../cAMP-response element signaling ...
14
High expression of cAMP responsive element binding protein 1 (CREB1) is associated with metastasis, tumor stage and poor outcome in gastric cancer
... 5. Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol. 2001; 2:599–609. 6. Rudolph D, Tafuri A, Gass P, Hammerling GJ, Arnold B, Schütz G. Impaired fetal T ...
12
Original Article Distribution of phosphorylated cyclic AMP response element binding protein (p-CREB-1) in rat retina
... State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China. * Equal contributors. Received October 11, 2016; Accepted October 25, 2016; Epub February 1, ...
10
Identification of a New camp Response Element-binding Factor by Southwestern Blotting*
... To confirm that the 34-40-kDa protein bands detectable on the Southwestern blots corresponded to different isoforms of the CREB factor, we compared the pattern of liver nuclea[r] ...
5
The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein.
... mutant protein with a deleted zinc finger, did not ...allowed binding somewhat similar to that allowed by the wild ...for binding and visualized by Coomassie blue staining of the gel shown in ...the ...
6
Deficits in amygdaloid cAMP responsive element–binding protein signaling play a role in genetic predisposition to anxiety and alcoholism
... of cAMP-responsive element–binding protein (CREB) in genetic predisposition to anxiety and alcohol-drinking behaviors using alcohol-preferring (P) and -nonpreferring (NP) ...
13
The cAMP responsive element binding protein 1 transactivates epithelial membrane protein 2, a potential tumor suppressor in the urinary bladder urothelial carcinoma
... EMP2 protein levels, and that the EMP2 was transactivated by ...CREB binding protein (CREBBP) is ...box binding protein-associated factor, 135 kDa (TAF4) to stimulate the deposition of ...
20
The cAMP response element modulator (CREM) regulates T 2 mediated inflammation
... by binding and suppression of the IFN-γ promoter during T H 2 differentiation ...ATF3 binding sites were found enriched in a recent epigenomic analysis of regulated genes that play a role for T H 2 memory ...
14
Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling
... of protein from normoxic and various time periods of hypoxic ret- inal extracts were analyzed by Western blotting for the indicated proteins using their specific antibodies and normalized to ...of protein ...
18
Human papillomavirus type 16 E6 protein transcriptionally modulates fibronectin gene expression by induction of protein complexes binding to the cyclic AMP response element.
... induces protein DNA binding complexes containing c-Jun and ...DNA binding domains can be enhanced by E6, we performed cotransfection ...Gal4 binding sites in front of a TATA box of the E1B ...
9
Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human Immunodeficiency Virus Type 1 Transcription in Cells of the Monocyte/Macrophage Lineage
... the binding of C/EBP pro- teins to an immediately adjacent C/EBP binding site I that exhibits very low affinity for C/EBP ...C/EBP binding appears to occur by two ...a binding site consisting ...
15
Human SNF2L Gene Is Regulated Constitutively and Inducibly in Neural Cells via a cAMP Response Element
... In the present study, we investigated the phosphorylation effects of forskolin or dbcAMP on CREB in the SNF2L promoter. Phosphorylated CREB levels were significantly increased in both SH-SY5Y cells and rat primary ...
6