The DNA binding domain
Autoimmunogenicity of the helix-loop-helix DNA-binding domain
... peptide- DNA complex induced autoantibodies against double-stranded DNA, histones, heterochromatin, and kidney proteins; glomerular IgG and IgA deposition; proteinuria; thrombocytopenia, and ...
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Investigation of the DNA binding domain of nuclear factor I
... of DNA (figure ...in DNA binding. Most of the DNA binding region, from residue 2 to 178, is encoded from a single ...active DNA binding ...reduced DNA ...
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Human herpesvirus 6B origin-binding protein: DNA-binding domain and consensus binding sequence.
... H6B DNA-binding domain by EMSA with in vitro-translated OBP H6B ...The DNA-binding activity of these truncated forms of OBP H6B was analyzed by EMSA ...added DNA contained ...
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MMPP Attenuates Non-Small Cell Lung Cancer Growth by Inhibiting the STAT3 DNA-Binding Activity via Direct Binding to the STAT3 DNA-Binding Domain
... direct binding to the SH2 domain [6, ...SH2 domain remains the main focus for designing small-molecule inhibitors, there has been a growing interest in developing specific inhibitors that can target ...
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The DNA-binding domain of OmpR: crystal structures of a winged helix transcription factor
... C-terminal DNA-binding domain of OmpR (OmpRc), determined at ...of DNA-binding pro- ...in DNA binding, and an extensive loop preceding the recognition helix involved in ...
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Maximal Stimulation of Meiotic Recombination by a Yeast Transcription Factor Requires the Transcription Activation Domain and a DNA-Binding Domain
... The DNA sequences located upstream of the yeast HIS4 represent a very strong meiotic recombination ...activation domain of the protein. We show that a hybrid protein with the Gal4p DNA-binding ...
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Essential role of the Vp2 and Vp3 DNA-binding domain in simian virus 40 morphogenesis.
... a DNA-binding domain and a Vp1 interactive determinant have been mapped to the carboxy-terminal 40 residues of the simian virus 40 (SV40) minor capsid proteins, Vp2 and Vp3 (Vp2/3), with the last 13 ...
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An unexpected role for Dicer as a reader of the unacetylated DNA binding domain of p53 in transcriptional regulation
... the DNA binding domain (DBD) of p53 in a manner dependent on its acetylation ...Upon binding the unacetylated DBD, Dicer is recruited to the pro- moters of p53 target genes, where it represses ...
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Two Patches of Amino Acids on the E2 DNA Binding Domain Define the Surface for Interaction with E1
... Cooperative DNA binding plays a prominent role as a reg- ulatory device for control of gene expression and DNA repli- ...cooperative DNA binding is to achieve increased specificity or ...
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Crystal Structure of the DNA-Binding Domain of Human Herpesvirus 6A Immediate Early Protein 2
... a DNA-binding domain shared with other betaherpesviruses such as human herpesvirus 7 and human ...the DNA-binding domain of HHV-6A IE2 was determined and analyzed, enabling a ...
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MD Simulations of the P53 oncoprotein structure: the effect of the Arg273→His mutation on the DNA binding domain
... E-mail: * [email protected] Received 26 July 2011; revised 25 August 2011; accepted 15 September 2011. ABSTRACT A comparative molecular dynamics (MD) simulation study was performed on the p53 oncoprotein to inve- stigate the ...
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The N-Terminal DNA-Binding Domain of Rad52 Promotes RAD51-Independent Recombination in Saccharomyces cerevisiae
... interacting domain, and studied its role in RAD51-independent ...N-terminal DNA-binding domain, promote an essential reaction in recombination in the absence of ...
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DNA binding properties of a chemically synthesized DNA binding domain of hRFX1
... of DNA recognition by proteins of the RFX family, the DBD of hRFX1 (hRFX1/DBD) was chosen as a ...this domain (76 amino acids) was achieved by the solid phase method, which required optimization of several ...
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Characterization of a major DNA-binding domain in the herpes simplex virus type 1 DNA-binding protein (ICP8).
... We have studied the major DNA-binding protein (ICP8) from herpes simplex virus type 1 to identify its DNA-binding site.. Since we obtained our protein from a cell line carrying multiple [r] ...
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Characterization of the DNA-Binding Domain of the Bovine Papillomavirus Replication Initiator E1
... Thus, the palindromic E1 binding site may contain four binding sites for E1. The result of this study suggest that E1 binds as two monomers to the sequence element ATNGTT NNNAACNAT in the E1E2-ori complex. ...
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Functional Mapping of the DNA Binding Domain of Bovine Papillomavirus E1 Protein
... the binding-functional mutations that we isolated are random in nature, interpretations that go be- yond simple classification of these residues as nonessential for sequence-specific DNA binding are ...
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Separation of the complex DNA binding domain of EBNA-1 into DNA recognition and dimerization subdomains of novel structure.
... Comparison of binding of group II (485D and 511VY) and group IV (477A-SR and 467VD) polypeptides to mutant oligomer probes. Mobility shift assays were performed as described in the legen[r] ...
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Determination of the origin-specific DNA-binding domain of polyomavirus large T antigen.
... N-terminal amino acids bound specifically to polyomavirus origin DNA; however, deletions beyond this site resulted in unstable proteins which could not be tested for DNA binding.. Testin[r] ...
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Simian virus 40 origin DNA-binding domain on large T antigen.
... Fifty variant forms of simian virus 40 (SV40) large T antigen bearing point, multiple point, deletion, or termination mutations within a region of the protein thought to be involved in D[r] ...
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Mutations in the DNA-binding domain of NR2E3 affect in vivo dimerization and interaction with CRX.
... vitro DNA-binding of NR2E3 proteins was tested on a radiolabeled consensus DR1 response element [1] with a 100-fold excess of either non-specific (2) or specific (+) competitor ...by binding of the ...
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