thymocyte development
Important Functional Roles of Basigin in Thymocyte Development and T cell Activation
... control mice (Supplementary Material: Fig. S1). The above results indicated that basigin expression in T lymphocytes is necessary for thymocyte development, particularly at the DP and CD4SP stage. Since the ...
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A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation
... This time series analysis of the transcriptional changes induced by pre-TCR signalling in a synchronised population of developing thymocytes in their thymic environment uncovered a complex transcriptional response in the ...
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A genome wide transcriptional model of the complex response to pre TCR signalling during thymocyte differentiation
... This time series analysis of the transcriptional changes induced by pre-TCR signalling in a synchronised population of developing thymocytes in their thymic environment uncovered a complex transcriptional response ...
15
Adenosine kinase inhibition promotes survival of fetal adenosine deaminase–deficient thymocytes by blocking dATP accumulation
... deaminase–deficient (ADA-deficient) murine fetal thymic organ cultures (FTOCs) due to the accu- mulation of ADA substrates derived from thymocytes failing developmental checkpoints. Such cul- tures can be rescued by ...
9
Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness
... normal thymocyte development and T cell proliferation (the stimulus was not reported) ...physiologic thymocyte development ...in thymocyte selection and the establishment of an ...
12
jem200101315.pdf
... in thymocyte development, we expressed the mutant p115 DH protein that specifically inactivates G 12/13 signaling (26–28) in the pHSPG retroviral vec- tor ...
10
Insights into thymic purine metabolism and adenosine deaminase deficiency revealed by transgenic mice overexpressing ecto 5' nucleotidase (CD73)
... in thymocyte development is not well defined, and the reason for the regulated expression of this enzyme in the thymus is ...in thymocyte development and purine metabolism, we created lck NT ...
9
Leptin protects mice from starvation induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
... gen-specific thymocyte development and survival is becoming increasingly recognized ...cortical thymocyte subpopulation in particular (47), it is still possible that suppression of the HPA axis may ...
10
Opposing chemokine gradients control human thymocyte migration in situ
... human thymocyte migration within a living 3-dimensional thymic stromal environment: the human→mouse system allowed for manipula- tion of stromal cell environments using genetically engineered mice, and the ...
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Transcriptional Control of D-beta-2
... during thymocyte development, we used nuclear extract from 2017 T-cell line (DN1), BW5147 mature T-cell line (SP CD8+), and mature B cell line (M12) to test the ability of each Runx protein to bind the ...
161
Human T-cell leukemia virus type I-induced proliferation of human immature CD2+CD3- thymocytes.
... These results clearly indicate that HTLV-I virions, in the presence of PHA, are able to trigger immature thymocyte proliferation by upregulating the expression of IL-2 receptors and by i[r] ...
9
Activation of protein breakdown and prostaglandin E2 production in rat skeletal muscle in fever is signaled by a macrophage product distinct from interleukin 1 or other known monokines
... epidermal thymocyte-activating factor, eosinophil cytotoxicity-enhancing factor, interferon-alpha, beta, and gamma, platelet-derived growth factor, and transforming growth factor (TGF) beta, which are all released ...
7
Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis.
... complete thymocyte loss in SCID-hu mice and did so without productive infection of ...HIV-related thymocyte depletion include direct in- fection of CD4 1 cells and precursors, causing apoptosis (9, 22), ...
8
CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus.
... Human immunodeficiency virus type 1 (HIV-1) infection of the human thymus results in depletion of CD4-bearing thymocytes. This depletion is initially manifested in the immature CD4 1 /CD8 1 thymocyte subset. To ...
7
Higher Activities of Hepatic Versus Splenic CD8+ T Cells in Responses to Adoptive T Cell Therapy and Vaccination of B6 Mice with MHC Class-1 Binding Antigen
... Creation of an immunostimulatory environment in the liver during peptide vaccination is critical since injection of peptide alone has been found to result in a transient expansion of the antigen-specific T cells followed ...
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Bicyclams, Selective Antagonists of the Human Chemokine Receptor CXCR4, Potently Inhibit Feline Immunodeficiency Virus Replication
... in thymocyte cultures, suggesting that the use of CXCR4 as a (co)receptor is not just a property of the CRFK-cell-adapted strains of FIV but that CXCR4 is also the main (co)receptor used by FIV isolates to infect ...
7
Thymocyte emigration is mediated by active movement away from stroma derived factors
... cell development in the thymus occurs in a stepwise manner and involves the sequential interaction of T cell precursors with epithelial and perivascular elements in the organ (1, ...
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Dissection of signalling pathways involved in the induction of apoptosis in a murine thymocyte cell line
... Generation of and analysis of apoptosis resistant mutant cell lin es. 145.[r] ...
340
Mechanisms of apoptotic induction by iron chelators
... the development and clonal deletion o f ...during thymocyte maturation, when up to 90% o f immature T cells are deleted by apoptosis during the processes o f positive and negative selection that shape the ...
280
Morillon_unc_0153D_14783.pdf
... critical to block the multi-organ autoimmunity typical of NOD.Aire null mice (37). Our observation that recipients developed significant infiltration of the ovaries, stomach, lungs and eyes implanted with newborn and ...
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