Transforming growth factor β
Transforming growth factor-β and abdominal aortic aneurysms
... death. Transforming growth factor- β (TGFβ) has been implicated as causative in the development of thoracic aortic aneurysms ...TGF β inhibits AAA development. Polymorphisms in the TGF ...
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Targeting Transforming Growth Factor β (TGF β) in Cancer and Non Neoplastic Diseases
... Transforming growth factor-β (TGF-β) superfamily is a key player in the regulation of a wide va- riety of physiological processes from development to ...
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Transforming growth factor β signaling in uterine development and function
... Endometrial hyperplasia is a pathological condition where endometrial cells undergo excessive proliferation [123]. Categories of endometrial hyperplasia include simple hyperplasia, simple atypical hyperplasia, complex ...
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Expression of transforming growth factor-β (TGF-β) in chronic idiopathic cough
... produce growth factors such as TGF- and endothelin and epidermal growth fac- tor (EGF)-like growth factors when subjected to mechani- cal stress or pressure ...
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Transforming growth factor β stimulates nerve growth factor production in osteoarthritic synovium
... We examined the mechanisms governing NGF regula- tion in the SYT of KOA patients. Our findings demon- strate a correlation between TGFB and NGF expression, and both TGF-β and NGF protein were localized to the ...
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Transforming Growth Factor Β in Psoriasis: Pathogenesis and Therapy
... prominent alterations in dermal capillary vasculature~and the presence of dermal and epidermal T cells, monocytehacrophages, and polymorphonuclear leukocytes?.6 We have recently shown th[r] ...
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Transforming growth factor-β pathway activity in glioblastoma
... Finally, the absence of a strong correlation between any TGF-β-related parameter and Ki-67 labeling (Table 2) indicates that stimulation of proliferation is not an important role of the TGF-β pathway in ...
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Transforming Growth Factor – β and Glioma
... Transforming growth factor-beta (TGF-β) is a regulatory cytokine secreted by various types of cell such as stromal cell, immune cells and tumor ...
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Transforming growth factor β and breast cancer: Mammary gland development
... TGF- β comes from studies of cultured cells exposed to recombinant or purified active ...TGF- β in mammary gland are not well understood, which is due in part to the complexity of its effects on different ...
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Role of transforming growth factor β isoforms in the pathogenesis of pulmonary fibrosis
... nuclear factor-1 (NF-l)-like and AP I binding sites are thought to be partly reponsible for mediating the effects of TGFBi (Rossi et al 1988; Chung et al ...
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Review Article The relationship of transforming growth factor-β and lung cancer
... cell growth and differentiation [10, ...cell factor can change the phenotype of normal fibroblast, that is, in case epidermal growth factor (EGF) co-exists, it changes the wall-adherent ...
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Tumour stromal interactions: Transforming growth factor β isoforms and hepatocyte growth factor/scatter factor in mammary gland ductal morphogenesis
... Hepatocyte growth factor/scatter factor HGF/SF, originally identified by its motogenic activity on cultured cells, is a pleiotropic cytokine that promotes sur- vival and proliferation in a wide ...
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Transforming growth factor β and breast cancer: Cell cycle arrest by transforming growth factor β and its disruption in cancer
... TGF- β -induced G 1 arrest occurs through induction of p15 and p21 genes, repres- sion of the c-myc, Cdc25A, cyclin E and cyclin A genes, and an increase in the association of p15, p21 and p27 with target ...How ...
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Transforming growth factor β and breast cancer: Transforming growth factor β/SMAD signaling defects and cancer
... that lead to expression of an AML1/Evi-1 fusion product under the control of the AML1 promoter [97]. The biological functions of Evi-1 are not well defined, but one way of contributing to a transformed phenotype may be ...
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Transforming growth factor beta and breast cancer: Tumor promoting effects of transforming growth factor β
... blocks growth inhibition by TGF- β , but also subverts this pathway into one that can stimulate epithelial-to-mesenchymal transdifferentiation [17 • ,20 • ...TGF- β -mediated growth ...TGF- ...
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Genetic analysis of female infertility with the effect of human bmp15 and gdf9 genes: a review
... the transforming growth factor-β (TGF- β) super family: growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) originates from oocytes are played ...
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Growth differentiation factor 9 and bone morphogenetic protein 15 expression in previtellogenic oocytes and during early embryonic development of Yellow-tail Kingfish Seriola lalandi
... the transforming growth factor β super family (TGF-β), GDF9 and BMP15 ...These growth factors stimulate the proliferation of granu- lose cells, but also suppress follicle ...
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Peripheral chondrosarcoma progression is accompanied
... of growth plates in long ...the growth plate, but is reactivated when these tumours undergo malignant transformation towards secondary peripheral ...that transforming growth ...
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Current progress in understanding the molecular pathogenesis of burn scar contracture
... secrete transforming growth factor- β 1 (TGF- β 1) and other cytokines, which can promote persistent myofibroblast activation via a positive regulation ...initiation factor 6 ...
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The Role of Cytokine Interleukin 2, Transcription Factor of FoxP3 in the Immunological Regulation of Allergic Rhinitis
... and Transforming Growth Factor- β (TGF- β ) ...TGF- β play a role in suppressing specific immune responses Th1 and T2 ...forkheadbox factor (FoxP3) that con- tributes to ...
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