zebrafish embryo
Toxicity evaluation of biodegradable chitosan nanoparticles using a zebrafish embryo model
... the zebrafish embryo as a rapid, medium throughput, cost-effective whole animal model to assess the toxicity of the biodegradable drug/gene carrier, ie, chitosan ...
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Zebrafish embryo, a tool to study tumor angiogenesis
... molecules, zebrafish allows disease-driven drug target identification and in vivo validation, thus representing an interesting bioassay tool for small molecule testing and dissection of biological pathways ...
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Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo
... The zebrafish model has proven valuable to our understanding of HSPC development, including the first direct in vivo visualization of their emergence (Bertrand et ...and zebrafish (Chen et ...the ...
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Positive and Negative Regulation of Gli Activity by Kif7 in the Zebrafish Embryo
... in zebrafish, Kif7 acts principally to suppress the activity of the Gli1 transcription ...that zebrafish Kif7 potentiates Gli2a activity by promoting its dissociation from the Suppressor of Fused (Sufu) ...
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
... The zebrafish embryo (ZFE) is a promising non-rodent model in toxicology, and initial studies suggested its applicability in detecting hepatotoxic ...
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Fgf signalling controls the dorsoventral patterning of the zebrafish embryo
... In the zebrafish embryo, three genes encoding Bmps, bmp2b, bmp7 and bmp4, are expressed at blastula and gastrula stages (Kishimoto et al., 1997; Nikaido et al., 1997; Dick et al., 2000; Schmid et al., ...
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Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model
... CCL4 administration does not induce liver fibrosis in zebrafish embryos. Due to the hydrophobic characteristic of CCL4, this compound could not be dissolved in the egg water and was therefore injected in the yolk ...
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The aquatic vertebrate embryo as a sentinel for toxins: zebrafish embryo dechorionation and perivitelline space microinjection
... Int T De> BioI 41 4] 1 423 (1997) 411 The aquatic vertebrate embryo as a sentinel for toxins zebrafish embryo dechorionation and perivitelline space microinjection MERLE MIZEll" and ERIC S ROMIG Depar[.] ...
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Early development and wound healing in the Zebrafish embryo
... the Zebrafish embryo to study these cell shape changes both by Scanning Electron Microscopy (SEM) and in real time using time-lapse analysis of vitally-stained embryos, and made direct comparisons with the ...
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The zebrafish embryo as a model to quantify early inflammatory cell responses to biomaterials
... a zebrafish embryo model which allows real time analysis of these responses to biomaterial ...genic zebrafish lines expressing distinct fluorescent proteins in their neutrophils and ...the ...
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Insulin like growth factor (IGF) signalling is required for early dorso anterior development of the zebrafish embryo
... in zebrafish are similar to those in mammalian systems and that IGF-1 binds to the IGF-1R and activates the MAPK- and the PI3K pathways in the zebrafish ZF-4 cell line (Pozios et al ...in zebrafish ...
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Innate immune signalling of the zebrafish embryo
... the zebrafish genome for genes encoding members of TLR signalling pathway leading to the identification of the zebrafish counterparts of the human TLRs and adapter proteins ...the zebrafish homologs ...
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Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo
... Evans, C. J., Hartenstein, V. and Banerjee, U. (2003). Thicker than blood: Fig. 6. Model of hematopoietic ontogeny in the zebrafish embryo. (A) Different regions of lateral plate mesoderm (LPM) give rise to ...
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Paralogues of Mmp11 and Timp4 Interact during the Development of the Myotendinous Junction in the Zebrafish Embryo
... We generated a construct encoding EMMA–Mmp11a, expressed it transiently in embryos under control of the heat shock promoter, and analyzed the activation of the epitope tagged construct in the absence and presence of 50 ...
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In vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems
... We identified several analogs with potent activity against the inflammatory response in vivo at low concentrations compared to previous studies of other thalidomide analogs [23]. Of these compounds, C2, C7, C58, C59 and ...
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Maternal Nanog is required for zebrafish embryo architecture and for cell viability during gastrulation
... Fig. 4. Multiple abnormalities in MZnanog embryo architecture. (A-D) YSL (white arrows) forms normally in MZnanog. Lateral optical sections of wild type (WT; A,B) and MZnanog (C,D) stained for nuclei (SYTOX green) ...
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Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo
... Cardiovascular progenitor cells (CPCs) represent the building blocks of the developing vertebrate heart. CPCs have the potential to form the major cardiovascular cell types (cardiomyocytes, endothelial and smooth muscle ...
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Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo
... (2004). FISHing for chick genes: triple-label whole-mount fluorescence in situ Fig. 7. Snail1a and Snail1b cooperate in the directed anterior migration of the axial mesendoderm. (A-D) Morphological appearance of control ...
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Use of the Zebrafish Embryo Toxicity Test for Risk Assessment Purpose: Case Study
... in zebrafish was useful to ascertain the quality and capacity to sustain life of the water samples taken at different points along the Atoyac and Xochiac rivers which flow through an industrial ...
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Slow calcium waves mediate furrow microtubule reorganization and germ plasm compaction in the early zebrafish embryo
... Zebrafish germ plasm ribonucleoparticles (RNPs) become recruited to furrows of early zebrafish embryos through their association with astral microtubules ends. During the initiation of cytokinesis, ...
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