[PDF] Top 20 Activation of gene expression by herpes simplex virus type 1 ICP0 occurs at the level of mRNA synthesis.
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Activation of gene expression by herpes simplex virus type 1 ICP0 occurs at the level of mRNA synthesis.
... the activation of herpes simplex virus type 1 (HSV-1) gene expression during lytic infection and reactivation from viral ...that ICP0 acts at the ... See full document
13
Efficient Activation of Viral Genomes by Levels of Herpes Simplex Virus ICP0 Insufficient To Affect Cellular Gene Expression or Cell Survival
... HSV-1 ICP0 during infection is considered to be the promotion of lytic cycle events via the ability of ICP0 to activate, or derepress, viral gene expression facilitating the ... See full document
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Perturbation of Cell Cycle Progression and Cellular Gene Expression as a Function of Herpes Simplex Virus ICP0
... of gene expression by ICP0 is considered to occur at the level of mRNA synthesis (44, ...75). ICP0 does not bind DNA (27), suggesting that ICP0 may activate ... See full document
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Neurons Differentially Activate the Herpes Simplex Virus Type 1 Immediate-Early Gene ICP0 and ICP27 Promoters in Transgenic Mice
... VP16 gene deleted can establish a latent infection and reactivate (57) and there is no evidence that VP16 is present in latently infected neurons, it does not appear that VP16 is involved in reactivation from ... See full document
11
Impact of the Interaction between Herpes Simplex Virus Type 1 Regulatory Protein ICP0 and Ubiquitin-Specific Protease USP7 on Activation of Adeno-Associated Virus Type 2 rep Gene Expression
... mutant virus dl1403, from which all the other ICP0 mutant viruses were ...harvested 1 h later. ICP0 levels were analyzed by Western blot- ...of ICP0 were determined by densitom- etry. ... See full document
5
Recruitment of Herpes Simplex Virus Type 1 Immediate-Early Protein ICP0 to the Virus Particle
... before ICP0 translocates into the cytoplasm (21, ...late gene product(s), as inhibition of DNA synthesis results in nu- clear retention of ICP0 ...of ICP0 to translocate in this ICP27- ... See full document
15
Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication
... RanBP10 mRNA, was constructed as ...RanBP10 mRNA, was cloned into the BamHI and SalI sites of pSSCH, which is a derivative of the retrovirus vector pMX containing a hygromycin B resistance gene (36), ... See full document
14
Role of Cyclin D3 in the Biology of Herpes Simplex Virus 1 ICP0
... that ICP0 carrying the D199A substitution failed to be trans- ported to the ...of ICP0 local- ization was first reported by Kawaguchi et ...of ICP0 in ...that ICP0 is transported into the ... See full document
11
Point mutations in the herpes simplex virus type 1 Vmw110 RING finger helix affect activation of gene expression, viral growth,
... IE gene products have significant or essential roles in the regulation of lytic viral gene ...IE gene 1 (IE-1) (Vmw110 or ICP0) appears to be involved in both lytic growth and ... See full document
7
Mutational analysis of ICP0R, a transrepressor protein created by alternative splicing of the ICP0 gene of herpes simplex virus type 1.
... high-level expression of ICP0R in a plasmid transfection assay ...the expression of these mutants could be tightly controlled through a negative autoregulatory ...of ICP0 protein were ... See full document
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Reactivation of Expression from Quiescent Herpes Simplex Virus Type 1 Genomes in the Absence of Immediate-Early Protein ICP0
... Gene expression during coinfection and ...during ICP0-null infections, some viral genomes failed to replicate even in cells supporting active virus ...the level of gene ...that ... See full document
9
The Initiator Element in a Herpes Simplex Virus Type 1 Late-Gene Promoter Enhances Activation by ICP4, Resulting in Abundant Late-Gene Expression
... late- gene expression during viral ...for expression to occur ...a gene expression profile more closely resembling that of early ...DNA synthesis, it may con- tribute to true ... See full document
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The NH2 Terminus of the Herpes Simplex Virus Type 1 Regulatory Protein ICP0 Contains a Promoter-Specific Transcription Activation Domain
... a0 gene can be complemented in L7 cells (55), which express ICP0 under the control of its endogenous promoter/regulatory ...that ICP0-N/X may be a dominant negative inhibitor of wild-type ... See full document
11
Reversal of Heterochromatic Silencing of Quiescent Herpes Simplex Virus Type 1 by ICP0
... latent herpes simplex virus genomes are to some degree found in a heterochromatic state, and this contributes to reduced gene expression resulting in ...of ICP0 in trans, to ... See full document
12
Herpes Simplex Virus Type 1 ICP0 Phosphorylation Mutants Impair the E3 Ubiquitin Ligase Activity of ICP0 in a Cell Type-Dependent Manner
... The activation of viral gene expression by ICP0 is closely associated with its capacity to disrupt nuclear domain 10 (ND10) structures (also known as protein promyelocytic leukemia [PML] ... See full document
10
Processing of α-Globin and ICP0 mRNA in Cells Infected with Herpes Simplex Virus Type 1 ICP27 Mutants
... functional mRNA molecules in the ...the expression of reporter genes driven by HSV promoters in transient cotransfection assays (17, 30, 41, 42, 45, 53, ...the activation and repres- sion was at the ... See full document
13
Herpes Simplex Virus Type 1 ICP0 Protein Mediates Activation of Adeno-Associated Virus Type 2 rep Gene Expression from a Latent Integrated Form
... of ICP0 was shown to be required for all biological activities of the protein and for efficient viral growth ...Rep synthesis was observed with this mutant ...that ICP0 alone was able to induce Rep ... See full document
10
Mutational analysis of the herpes simplex virus type 1 ICP0 C3HC4 zinc ring finger reveals a requirement for ICP0 in the expression of the essential alpha27 gene.
... temporal expression during productive infec- tions (37, 38, ...the virus genome, and late genes, which encode many of the structural components of the HSV virion, requires the prior synthesis of a ... See full document
13
Deletion of the Herpes Simplex Virus VP22-Encoding Gene (UL49) Alters the Expression, Localization, and Virion Incorporation of ICP0
... the herpes simplex virus tegument protein VP22 is not yet ...a virus in which the entire VP22 open reading frame has been ...for virus growth but that virus lacking VP22 ( ⌬ 22) ... See full document
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ICP0 Gene Expression Is a Herpes Simplex Virus Type 1 Apoptotic Trigger
... Human herpes simplex virus type 1 (HSV-1) is a large DNA virus (25) whose infection is characterized by the establishment of latency in neuronal cells (60) and the ... See full document
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