[PDF] Top 20 Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity.
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Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity.
... Since the mRNAs using the competing SA4a, SA4b, SA4c, and SA5 splice sites are multicistronic, potentially coding several proteins from each mRNA 15, 48, 49, we examined the effect of al[r] ... See full document
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Role of Cellular RNA Processing Factors in Human Immunodeficiency Virus Type 1 mRNA Metabolism, Replication, and Infectivity
... the human immunodeficiency virus type 1 genome requires several cellular factors regulating transcription, alternative splicing, RNA stability, and intracellular ... See full document
12
RNA Structure Modulates Splicing Efficiency at the Human Immunodeficiency Virus Type 1 Major Splice Donor
... The human immunodeficiency virus type 1 (HIV-1) proviral DNA genome expresses a primary transcript of 9 kb that serves not only as genomic RNA for progeny virus but also ... See full document
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CDK13, a New Potential Human Immunodeficiency Virus Type 1 Inhibitory Factor Regulating Viral mRNA Splicing
... of viral mRNA splicing regulation ...the splicing inhibitor p32 in vitro and that both pro- teins colocalize in the nucleus and more specifically on the HIV-1 ...HIV-1 ... See full document
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Negative and Positive mRNA Splicing Elements Act Competitively To Regulate Human Immunodeficiency Virus Type 1 Vif Gene Expression
... tat/rev mRNA splic- ing ...increase splicing at 3 ⬘ ss A3 and A7, respectively (4, 26, 27, 35). The splicing of vpr mRNA, which is also present in low abundance in infected cells, is regulated ... See full document
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Role for Human Immunodeficiency Virus Type 1 Tat Protein in Suppression of Viral Reverse Transcriptase Activity during Late Stages of Viral Replication
... Tat protein, containing both Tat exons ...(i.e., 1-exon-Tat) could not. Conversely, HIV-1 molecular clones expressing 2-exon-Tat (pNL43 and pNL101) showed more rapid replication kinetics and ... See full document
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Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.
... pro- viral DNA clone of HIV-1 (1), and virus stocks were produced by transfecting HeLa or 293 ...in replication, such as receptor-mediated entry, reverse transcription, and integra- ... See full document
8
Cellular and Viral Specificities of Human Immunodeficiency Virus Type 1 Vif Protein
... of human immunodeficiency virus type 1 (HIV-1) greatly enhances the infectivity of HIV-1 virions that are released from cells classified as nonpermissive ...vif ... See full document
6
Primary Sooty Mangabey Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2 nef Alleles Modulate Cell Surface Expression of Various Human Receptors and Enhance Viral Infectivity and Replication
... surface expression, it is noteworthy that some conserved Nef functions are mediated by different Nef ...adaptor protein interaction site in SIVmac239 Nef is required for CD4 down-modulation ... See full document
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The Secondary Structure of the Human Immunodeficiency Virus Type 1 Transcript Modulates Viral Splicing and Infectivity
... FIG. 1. A) Schematic representation of the main HIV-1 RNA ...the viral genes is indicated on the map on top. The viral genomic ( ⬃ 9-kb unspliced) mRNA shows the location of 5 ⬘ ss and ... See full document
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Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity and Replication Independently of Viral Coreceptor Tropism
... the viral envelope glycoprotein to CD4 and subsequent interactions with G protein-coupled coreceptors, usually CCR5 (R5) or CXCR4 (X4) (reviewed in reference ...surface expression of CD4 (8, 20), ... See full document
5
The Epstein Barr virus EBNA1 protein modulates the alternative splicing of cellular genes
... standard bioinformatic protocol (trimming using Trim- momatic, alignment using STAR on the hg38 genome, PCR and sequencing duplicates removal using samtools rmdup, peak calling with RIPSeeker). The analysis yielded 503 ... See full document
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Human Immunodeficiency Virus Type 1 Envelope-Mediated Neuronal Death: Uncoupling of Viral Replication and Neurotoxicity
... 2. Replication kinetics and cell entry by recombinant virus ...recombinant virus strains showed high RT levels in PBMCs (A); all of the virus strains tested (except pNL4-3) that replicated in ... See full document
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Human Immunodeficiency Virus Type 1 Replication Is Modulated by Host Cyclophilin A Expression Levels
... A expression in H9 cells is of functional relevance was provided by comparing the effects of cyclosporine on replication of the wild-type virus in the two cell ...cells, viral ... See full document
7
Nef from Human Immunodeficiency Virus Type 1F12 Inhibits Viral Production and Infectivity
... CD8–NL4-3–Nef protein distributed throughout the cytoplasm and at the plasma membrane in a punctate pattern and in structures reminiscent of the endoplas- mic reticulum and Golgi compartments ...CD8-F12-Nef ... See full document
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Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection
... A statistical comparison of the HIV-1 RNA levels among the three groups of children displaying the different patterns of HIV-1 infection (i.e., patterns A, B, and C, shown in Fig. 3, A, B, and C, ... See full document
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Formation of a Human Immunodeficiency Virus Type 1 Core of Optimal Stability Is Crucial for Viral Replication
... envelope protein (Env) at levels similar to those for wild- type HIV-1 (von Schwedler and Sundquist, ...the infectivity of each of the HIV-1 mutants was markedly reduced relative to ... See full document
11
The cytoplasmic domain of simian immunodeficiency virus transmembrane protein modulates infectivity.
... We investigated the function of the SIVmac envelope cytoplasmic domain by replacing the in-frame stop codon by 4395 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest A st[r] ... See full document
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Intracellular expression of RNA transcripts complementary to the human immunodeficiency virus type 1 gag gene inhibits viral replication in human CD4+ lymphocytes.
... FIG. 1. Structure and expression of retroviral vector carrying the antisense C-gag ...RNA expression in transduced CEMSS cell ...Lane 1, CEMSS wild type; lane 2, pLP-C-gag vector; lane ... See full document
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Host-derived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhance viral infectivity.
... Human immunodeficiency virus type 1 (HIV-1) acquires several host cell membrane proteins when it buds from infected ...transient expression system that has enabled us to ... See full document
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