[PDF] Top 20 Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase.
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Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase.
... not, by themselves, appear to be important in determining the sensitivity of HIV-1 RT to TBA, HEPT, or calanolide A, it is still possible that these substitutions could have an effect if[r] ... See full document
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Mutational analysis of the fingers domain of human immunodeficiency virus type 1 reverse transcriptase.
... The mutations are primarily single amino acid substitutions, but some involve 7533 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Using BspMI cassette vectors, we have [r] ... See full document
5
Characterization and Structural Analysis of Novel Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Involved in the Regulation of Resistance to Nonnucleoside Inhibitors
... at 1 (maximal positive association) to dissimilarity 0 and phi at ⫺1 (maximal negative association) to dissimilarity 1, with linear interpolation in ...of 1 for an edge in the dendrogram means ... See full document
13
Clinical data sets of human immunodeficiency virus type 1 reverse transcriptase-resistant mutants explained by a mathematical model.
... of human immunodeficiency virus type 1 (HIV-1) isolates resistant to protease- and reverse transcrip- tase (RT)-inhibiting drugs during treatment is well docu- ... See full document
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Effect of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Polymorphism Leu-214 on Replication Capacity and Drug Susceptibility
... modeling analysis of ZDVMP and dTMP interactions in the optimized complex of RT Phe-214/Tyr-215 (A and C) and RT Leu-214/Tyr-215 (B and D) bound to template primers blocked at their 3 ⬘ ... See full document
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Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
... affect both subunits of RT. Figure 3 shows that residue 348 of the p51 subunit is located remotely from the polymerase active site ( ⬃ 60 Å) and from the NNRTI binding pocket ( ⬃ 55 Å). Furthermore, it is not in close ... See full document
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Incorporation of Human Immunodeficiency Virus Type 1 Reverse Transcriptase into Virus-Like Particles
... genetic analysis suggest that the Gag-interacting regions of RT mainly reside in the thumb subdomain and that the RT-binding domains of Gag are located in the matrix (MA) and p6 ... See full document
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A Mutation in the 3′ Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Y318F) Associated with Nonnucleoside Reverse Transcriptase Inhibitor Resistance
... NVP, 1 had been previ- ously prescribed DLV and NVP, and 8 had never been pre- scribed any NNRTI before the genotype request ...square analysis of these 5,680 isolates revealed a highly statistically ... See full document
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Worldwide Evaluation of DNA Sequencing Approaches for Identification of Drug Resistance Mutations in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... The drug resistance-con- ferring mutations were located at three amino acid and four independent nucleotide positions, ...geno- type was present in at least 5% of the RT ...sequence analysis of one ... See full document
6
Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase.
... exogenous drug, and then ex- posed to virus. HIV-1 infection of UC781-pretreated MT2 cells was dramatically attenuated, as assessed by measurement of syncytium formation, p24 production, and/or RT ... See full document
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Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodeficiency Virus Type 1 Mutation Frequencies
... with drug resistance muta- tions, the effects of drug-resistant mutants and combined drugs on HIV-1 mutation frequencies were ...the virus mutation frequencies in the presence of ... See full document
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Individual Contributions of Mutant Protease and Reverse Transcriptase to Viral Infectivity, Replication, and Protein Maturation of Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
... (1/5, 1/25, and 1/125) and added to a 96-well plate with poly(rA) (enzyme template) bound to the bottom of the wells and with 150 l of reaction solution containing bromodeoxyuridine triphosphate as ... See full document
10
Minority Human Immunodeficiency Virus Type 1 Variants in Antiretroviral-Naive Persons with Reverse Transcriptase Codon 215 Revertant Mutations
... Human immunodeficiency virus type 1 (HIV-1) exists in vivo as a quasispecies consisting of innumerable genomic variants evolving through a process of mutation, recombi- ... See full document
9
Increased polymerase fidelity of E89G, a nucleoside analog-resistant variant of human immunodeficiency virus type 1 reverse transcriptase.
... the drug-resistant virus typically constitutes the majority in the virus population in that ...the drug-resistant mutant is indeed of a higher polymerase fidelity, it affords two ... See full document
5
Sequence and drug susceptibility of subtype C reverse transcriptase from human immunodeficiency virus type 1 seroconverters in Zimbabwe.
... (Table 1), Taq polymerase, and dye-labelled dideoxy terminators (Applied Biosystems, ...assay analysis. HIV-1 proviral DNA from cultured PBMC was amplified as previously described (1, 8, ... See full document
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Effects of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Reverse Transcriptase Processing, Activity, and Drug Sensitivity
... three virus pairs studied here were characterized by a strong difference in infectivity between the pretherapy and post resistance protease-reconstructed molecular clones (20, ...for virus 487-post did we ... See full document
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YADD Mutants of Human Immunodeficiency Virus Type 1 and Moloney Murine Leukemia Virus Reverse Transcriptase Are Resistant to Lamivudine Triphosphate (3TCTP) In Vitro
... B virus (HBV) RT and feline immunodeficiency virus (FIV) RT to 3TC (8, ...leukemia virus (MLV) has, in the wild-type en- zyme, ...tively resistant to 3TC. This prompted us to ... See full document
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Template Usage Is Responsible for the Preferential Acquisition of the K65R Reverse Transcriptase Mutation in Subtype C Variants of Human Immunodeficiency Virus Type 1
... any drug against which K65R confers resistance. Although the drug pressure that selects for K65R is similar in subtypes B and C, there is a fundamental difference between the two subtypes based on the ... See full document
5
Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720.
... Indeed, the quinoxaline derivative has broad-spectrum activity against various mutant HIV-1 strains that are resistant to other HIV-1-specific RT inhibitors; i.e., quinoxaline S-2720 is [r] ... See full document
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Ultrasensitive Allele-Specific PCR Reveals Rare Preexisting Drug-Resistant Variants and a Large Replicating Virus Population in Macaques Infected with a Simian Immunodeficiency Virus Containing Human Immunodeficiency Virus Reverse Transcriptase
... M184I drug resistance mutations before and after drug expo- sure and observe how they were maintained in the same propor- tion relative to the total virus population, consistent with the pre- dicted ... See full document
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