[PDF] Top 20 Adeno-Associated Virus Site-Specific Integration Is Mediated by Proteins of the Nonhomologous End-Joining Pathway
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Adeno-Associated Virus Site-Specific Integration Is Mediated by Proteins of the Nonhomologous End-Joining Pathway
... found associated with Artemis, a cellular endonuclease, and it has been experimentally demonstrated that the DNAPKcs-Arte- mis complex can cleave hairpin loops, flaps, and ...during integration and/or after ... See full document
10
A Helper-Dependent Capsid-Modified Adenovirus Vector Expressing Adeno-Associated Virus Rep78 Mediates Site-Specific Integration of a 27-Kilobase Transgene Cassette
... helper virus (with E1/E3 deleted) in HD-Ad ...helper virus replicates in infected cells, which results on one hand in the production of viral proteins and on the other hand in coreplication of HD-Ad ... See full document
11
Site-Specific Integration of an Adeno-Associated Virus Vector Plasmid Mediated by Regulated Expression of Rep Based on Cre-loxP Recombination
... Recombinant adeno-associated virus (AAV) type 2 has attracted attention because it appears to have the potential to serve as a vector for human gene ...its site-specific ... See full document
8
Mitochondrial Genome Maintenance: Roles for Nuclear Nonhomologous End-Joining Proteins in Saccharomyces cerevisiae
... are associated with sporadic and inherited diseases and age-associated neurodegenerative ...– mediated deletions (DRMDs) in the nuclear and mitochondrial ...recognition site that is not ... See full document
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Conditional Site-Specific Integration into Human Chromosome 19 by Using a Ligand-Dependent Chimeric Adeno-Associated Virus/Rep Protein
... and site-directed ...Rep proteins (Rep52 and Rep40) was mutated to glycine (nucleotides 993 to 995, ATG changed to GGA) and the splice donor site required for the expression of the spliced version ... See full document
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Efficient Site-Specific Integration of Large Transgenes by an Enhanced Herpes Simplex Virus/Adeno-Associated Virus Hybrid Amplicon Vector
... concatemer integration that occurred during standard amplicon ...⬘ end of the AAVS1 ...Rep-mediated integration could occur in either the flip or flop orientation with equal frequency, by ... See full document
8
Adeno-Associated Virus Type 2 p5 Promoter: a Rep-Regulated DNA Switch Element Functioning in Transcription, Replication, and Site-Specific Integration
... Rep proteins, p68 and p78, function as master controllers of the adeno-associated virus type 2 (AAV2) life cycle, involved in transcriptional control, in latency, in rescue, and in viral DNA ... See full document
10
Identification of Cellular Proteins That Interact with the Adeno-Associated Virus Rep Protein
... Ad virus (95, ...E4 proteins and may be more relevant when other helper viruses, such as herpes, are ...the site- specific integration of AAV genomes into chromosome 19 (63, 64, 81, ... See full document
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Roles of Adeno-Associated Virus Rep Protein and Human Chromosome 19 in Site-Specific Recombination
... Though site-specific integration is dependent upon either of the two large Rep proteins, the AAV ITRs are the only cis elements required for integration (34, 44, ...Rep proteins, ... See full document
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Mechanism of Rep-Mediated Adeno-Associated Virus Origin Nicking
... DNA, adeno-associated virus (AAV) genome is flanked by terminal repeats ...as integration and packaging signals (12, 21, ...a site-specific, single- stranded nick into the TRs by ... See full document
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Site-Specific Integration in Mammalian Cells Mediated by a New Hybrid Baculovirus–Adeno-Associated Virus Vector
... the site of gene ...of integration of the recombinant Ad genome and by the development of a strong cellular immune response to the genetically corrected cells that express low levels of viral ... See full document
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HMEJ-mediated efficient site-specific gene integration in chicken cells
... targeted integration (HITI), homology-directed repair (HDR) and homology mediated end joining (HMEJ) coupled with a clustered regularly interspaced short palindromic repeat associated ... See full document
10
CRISPR/Cas9-Induced Double-Strand Break Repair in Arabidopsis Nonhomologous End-Joining Mutants
... target site for the nuclease, the sequence will be cut again in the continuous presence of the ...target site. A repair template without the target site may be provided by transformation or ... See full document
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Reduction of MBS85 gene expression after the targeted integration of a transgene into the AAVS1 site using adeno-associated virus integration machinery
... AAVS1 site on chromosome 19 ...binding site (RBS), and cleaves it in a site and strandspecific manner at the terminal resolution site (trs) located 16 nt upstream of the ...Sitespecific ... See full document
7
Repair of Endonuclease-Induced Double-Strand Breaks in Saccharomyces cerevisiae: Essential Role for Genes Associated with Nonhomologous End-Joining
... DSBs associated with meiotic recombina- as ionizing radiation, bleomycin, and methylmethane tion, mating type switching, and intron homing in yeast; sulfonate ...cellular specific at-risk sequence motifs ... See full document
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Overcoming obstacles to nonhomologous end joining repair of chromosome double strand breaks
... that nonhomologous end joining ligates the proper DNA ends together (signal end to signal end and coding end to coding ...coding end present a more significant obstacle. ... See full document
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Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineage
... Cernunnos-XLF is a new component of the nonhomolo- gous end-joining machinery mutated in human immuno- deficiency with microcephaly [4,5]. Using newly obtained coding sequences in chimpanzee and rhesus ... See full document
12
CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome
... shows proteins that coimmunoprecipitated with FLAG-CDCA7 in an ICF3 mutation–sensitive manner (peptide number ≥ 5, R274C/WT < ...structure specific recognition protein 1 ... See full document
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Efficient Gene Replacements in Toxoplasma gondii Strains Deficient for Nonhomologous End Joining
... any nonhomologous recombination event (even if they occur), be- cause each targeting plasmid carries only a fragment of the HXGPRT gene that cannot confer MPA resistance in the ⌬ hxgprt ...recombination ... See full document
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Herpes Simplex Virus Type 1/Adeno-Associated Virus rep+ Hybrid Amplicon Vector Improves the Stability of Transgene Expression in Human Cells by Site-Specific Integration
... Rep proteins was evaluated by Western blot ...markers. Proteins were transferred to nitrocellulose membrane (Bio-Rad Trans-blot Transfer Medium Pure; ...Rep proteins (with molecular masses of 40, 52, ... See full document
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