[PDF] Top 20 DNA binding and gene regulation by the herpes simplex virus type 1 protein ICP4 and involvement of the TATA element.
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DNA binding and gene regulation by the herpes simplex virus type 1 protein ICP4 and involvement of the TATA element.
... The regions of the herpes simplex virus type 1 immediate early protein Vmw 175 required for site specific DNA binding closely correspond to those involved in transcriptional regulation..[r] ... See full document
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Binding of ICP4, TATA-Binding Protein, and RNA Polymerase II to Herpes Simplex Virus Type 1 Immediate-Early, Early, and Late Promoters in Virus-Infected Cells
... of ICP4 to the formation of transcription complexes on HSV promoters representative of different kinetic ...viral DNA in the stocks used to infect the cells, the probability that an infecting genome enters ... See full document
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The High Mobility Group Protein 1 Is a Coactivator of Herpes Simplex Virus ICP4 In Vitro
... of herpes simplex virus early and late gene transcription during infection and in vitro can efficiently activate the transcription of a core promoter template containing only a TATA box ... See full document
6
Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication.
... regulatory protein of herpes simplex virus type 1 (HSV- ...viral gene expres- sion during the course of infection. HSV-1 gene expression is regulated in an ... See full document
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Relationship between TATA-binding protein and herpes simplex virus type 1 ICP4 DNA-binding sites in complex formation and repression of transcription.
... relative TATA box and ICP4-binding-site position on tripartite complex formation and ...the ICP4 promoter sequence from 2 108 to 1 27 rela- tive to the transcription start site ...of ... See full document
8
Phosphorylation of the Herpes Simplex Virus Type 1 Origin Binding Protein
... origin binding activity of other viral replication initiator proteins, we sought to determine whether the phosphorylation state of OBP affects its ability to form protein-DNA complexes at its ... See full document
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Repression of the herpes simplex virus 1 alpha 4 gene by its gene product (ICP4) within the context of the viral genome is conditioned by the distance and stereoaxial alignment of the ICP4 DNA binding site relative to the TATA box.
... cell protein no. 4 (ICP4), the major regulatory protein encoded by the a 4 gene of herpes simplex virus 1, binds to a site ( a 4-2) at the transcription initiation ... See full document
7
Herpes Simplex Virus Type 1 ICP4 Promotes Transcription Preinitiation Complex Formation by Enhancing the Binding of TFIID to DNA
... with ICP4 and showed that, relative to ICP4, VP16 very poorly, if at all, helped recruit TFIID, despite its ability to recruit TFIIB and RNA Pol ...that ICP4 intervenes at a very early step in the ... See full document
7
Stabilized Binding of TBP to the TATA Box of Herpes Simplex Virus Type 1 Early (tk) and Late (gC) Promoters by TFIIA and ICP4
... that ICP4 has a differential requirement for the general transcription factor TFIIA in vitro ...for ICP4 activation of a late promoter (gC) but was required for the efficient activation of an early promoter ... See full document
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The Initiator Element in a Herpes Simplex Virus Type 1 Late-Gene Promoter Enhances Activation by ICP4, Resulting in Abundant Late-Gene Expression
... late- gene expression during viral ...required DNA replication for expression to occur ...a gene expression profile more closely resembling that of early ...for DNA synthesis, it may con- ... See full document
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DNA binding by the herpes simplex virus type 1 ICP4 protein is necessary for efficient down regulation of the ICP0 promoter.
... Regulation of the herpes simplex virus type 1 late Y2 glycoprotein c gene: sequences between base pairs 34 to +29 control transient expression and responsiveness to transactivation by th[r] ... See full document
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DNA-Dependent Oligomerization of Herpes Simplex Virus Type 1 Regulatory Protein ICP4
... the protein did not affect B complex formation, and (iii) an N-terminal domain mutant formed heterotetramers with WT ...specific ICP4 binding site and a downstream nonspecific stretch of DNA ... See full document
8
ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB.
... Specifically, the simultaneous addition of ICP4, rTFIIB, and rTBP to a DNA template containing an ICP4 binding site and a TATA box resulted in a unique complex lower in electrophoretic m[r] ... See full document
12
In vitro characterization of a thermolabile herpes simplex virus DNA-binding protein.
... 31 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The major herpes simplex virus DNA-binding protein, ICP8, was purified from cells infected with the herpes simplex vi[r] ... See full document
6
Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27.
... of ICP4, the correlation between the localization pattern of ICP4 and the expression level and localization pattern of ICP27 within a given infected cell had not been established ...with ICP4 mutants ... See full document
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ICP4-binding sites in the promoter and coding regions of the herpes simplex virus gD gene contribute to activation of in vitro transcription by ICP4.
... Our earlier experiments on the regulation of the HSV glycoprotein D gD gene located ICP4-binding sites in three DNA fragments near the gD mRNA start site; using an in vitro transcription[r] ... See full document
11
Thermolabile in vivo DNA-binding activity associated with a protein encoded by mutants of herpes simplex virus type 1.
... 3 Thermolabile In Vivo DNA-Binding Activity Associated with a Protein Encoded by Mutants of Herpes Simplex Virus Type 1 Received 30 December 1982/Accepted 17 March 1983 The major DNA-bin[r] ... See full document
11
Interaction with nucleic acids and stimulation of the viral DNA polymerase by the herpes simplex virus type 1 major DNA-binding protein.
... 727 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The interaction of the herpes simplex virus type 1 HSV-1 major DNA-binding protein, infected-cell polypeptide 8 ICP8[r] ... See full document
7
Properties of the novel herpes simplex virus type 1 origin binding protein, OBPC.
... Although OBP localizes to the nucleus (9), its nuclear local- ization signal has not been identified definitively. A motif present in all members of the SF2 superfamily of helicases (22, 35), as well as OBP and OBPC, has ... See full document
7
A second-site revertant of a defective herpes simplex virus ICP4 protein with restored regulatory activities and impaired DNA-binding properties.
... ICP4 has been shown to specifically interact with lower-affinity sites that differ significantly from the consensus sequence found in the vicinity of early and late gene promoters 23, 25[r] ... See full document
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