[PDF] Top 20 Cellular proteins bind to the downstream component of the lytic origin of DNA replication of Epstein-Barr virus.

... the downstream component of oriLyt by scanning deletion mutants (the replication efficiency of wild-type plasmid ...transient replication assay as described elsewhere (23) and whose ... See full document

... latency origin of ...EBV lytic cycle (9). Across the EBV latency origin of replication, we first observed high level transcription in reactivated Akata cells using non- strand-specific RNA-seq ... See full document

... of DNA damage response proteins at the viral replication compartment during lytic EBV ...of lytic reactivation (18, 29–31). During lytic cycle induction in EBV-infected B cells, ... See full document

... Epstein-Barr virus (EBV) productive DNA replication occurs at discrete sites, called replication compart- ments, in ...the replication compartments. The BZLF1 oriLyt ... See full document

... Epstein-Barr virus (EBV) is a human gammaherpesvirus 1 (also known as human herpesvirus 4 [HHV4]) and the etiolog- ical agent responsible for infectious mononucleosis, oral hairy leukoplakia, AIDS ... See full document

... the cellular proteins ZEB1 (also known as ␦ EF1, TCF8, AREB6, ZFHEP, NIL-2A, ZFHX1A, and BZP) and ZEB2 (also known as SIP1, SMA- DIP1, ZFHX1B, and KIAA0569) can both bind to a sequence element, ... See full document

... EBV DNA and EBV-specific anti-VCA and anti-EA antibodies in the neurological stage but not during convales- cence ...direct virus invasion of the central nervous system, although the pathogenesis is not ... See full document

... activates DNA replication and transcription, re- spectively, are currently unclear, although considerable infor- mation is accumulating on the mechanism of initiation of DNA replication from ... See full document

... of proteins is likely to be their role in facilitating export of intronless viral ...major cellular path- way for export of mRNAs by the formation of protein com- plexes near the splice junction (for ... See full document

... a DNA-bound TFIIA- TFIID ...oriLyt replication has been less ...oriLyt replication (41, 60, 61). A transcriptional contribution to replication by Zta seems ...abolishes replication ... See full document

... for Epstein-Barr virus (EBV) to evade the host immune response (for a review see reference ...the lytic repli- cation is frequently induced (3, 50), which ensures the produc- tion of progeny ... See full document

... this virus is also clearly associated with several types of cancer such as Burkitt’s lymphoma and naso- pharyngeal carcinoma (reviewed in references 42 and 45), EBV is one of the most extensively studied human ... See full document

... Our DNA binding studies suggest that the BZLF1-BMRF1 complex may be incapable of binding to ZRE sites, potentially providing a mechanism by which expression of the BMRF1 gene product inhibits BMRF1 promoter ... See full document

... a DNA glycosylase assay ...BALF5 DNA polymerase after induction with 100 ng/ml doxycycline for 48 h ...viral replication was induced by cotransfection of the Rta expression plasmid ...viral ... See full document

... endogenous cellular control. DHX9 depletion led to a 3-fold increase in lytic transcript levels regardless of whether the genes were SM dependent or independent ...EBV proteins including BcRF1 (the ... See full document

... the DNA replication function, indicating that the looping domain plays an essential role in ...the DNA-binding ability of EBNA1 (5), the functional contribution of the loop- ing domain is likely in ... See full document

... and lytic cycle-inducing stimulus influence the kinetics of viral gene ...viral DNA replication inhibitor PAA in two cell lines of different tissue origins, namely, BZKO cells, which are derived from ... See full document

... herpesvirus replication has become increasingly important over the past few decades as the inci- dence of human immunosuppression has ...gammaherpesvirus, Epstein-Barr virus (EBV), is the ... See full document

... progeny DNA. Total cellular DNAs from noninduced and induced Akata cells carrying the oriP-oriLyt vector p562 were analyzed on two-dimensional agarose gels (top) and detected after Southern blot ...plasmid ... See full document

... the DNA polymerase pro- cessivity factor, two essential components of the EBV replication machinery (37, 40, ...viral replication proteins was ...tion proteins, we isolated RNA from ... See full document