[PDF] Top 20 Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding.
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Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding.
... HO,2 JAMES ROBINSON,3 AND JOSEPH SODROSKI 14* Received 22 January 1993/Accepted 5 April 1993 Interaction with the CD4 receptor enhances the exposure on the human immunodeficiency type 1 [r] ... See full document
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Simple enzyme immunoassay for titration of antibodies to the CD4 binding site of human immunodeficiency virus type 1 gp120
... contrast, characterization of discontinuous epitope(s) overlap- ping the CD4BS of gp120 and the study of antibodies that bind to this epitope remain more difficult because of the restrict- ing conditions of ... See full document
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Interaction with CD4 and Antibodies to CD4-Induced Epitopes of the Envelope gp120 from a Microglial Cell-Adapted Human Immunodeficiency Virus Type 1 Isolate
... with CD4 or CCR5, as described in Materials and ...that CD4 was incorpo- rated into virions at much higher levels than CCR5 (data not ...to CD4, to incorporate into MLV particles was reported ... See full document
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Discovery of Small-Molecule Human Immunodeficiency Virus Type 1 Entry Inhibitors That Target the gp120-Binding Domain of CD4
... the gp120-CD4 in- teraction involves relatively small contact surface areas on both ...HIV-1 gp120 core com- plexed with an N-terminal two-domain CD4 (D1/D2 CD4) and a Fab ... See full document
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Discontinuous, conserved neutralization epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoprotein.
... 9 Discontinuous, Conserved Neutralization Epitopes Overlapping the CD4-Binding Region of Human Immunodeficiency Virus Type 1 gpl20 Envelope Glycoprotein Received 6 March 1992/Accepted 1 [r] ... See full document
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Expression and Characterization of a Single-Chain Polypeptide Analogue of the Human Immunodeficiency Virus Type 1 gp120-CD4 Receptor Complex
... the gp120-CD4 complex, arises from the interaction of gp120 with the CD4 receptor and enables interactions with specific coreceptors needed for viral ...entry. gp120-CD4 ... See full document
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Immunization with a soluble CD4-gp120 complex preferentially induces neutralizing anti-human immunodeficiency virus type 1 antibodies directed to conformation-dependent epitopes of gp120.
... Conformational epitope on gpl20 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody.. Broadly neutralizing antibodie[r] ... See full document
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Equal levels of gp120 retention and neutralization resistance of phenotypically distinct primary human immunodeficiency virus type 1 variants upon soluble CD4 treatment.
... The CD4 molecule serves as the principal receptor for HIV-1 (9, 24, 28, ...glycoprotein gp120 with the CD4 molecule ultimately mediates a pH-independent fusion of virus and cell ... See full document
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Dissociation of the CD4 and CXCR4 Binding Properties of Human Immunodeficiency Virus Type 1 gp120 by Deletion of the First Putative Alpha-Helical Conserved Structure
... either gp120 wt or gp120 DaHX1 could inhibit the binding of SDF1a, the natural ligand of CXCR4 (4, ...the binding of SDF1a (10 mg/ml) decreased to ...of gp120 wt per ml, respectively ... See full document
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Characterization of a novel binding site for the human immunodeficiency virus type 1 envelope protein gp120 on human fetal astrocytes.
... 2 nor recombinant soluble CD4 protein up to 8 ,ug/ml had Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest 1251_labeled recombinant gpl20 bound to primary cultures of huma[r] ... See full document
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Identification of Conserved and Variable Structures in the Human Immunodeficiency Virus gp120 Glycoprotein of Importance for CXCR4 Binding
... of gp120 is the primary determinant for cell tropism and coreceptor usage (29, 32, 33, 60), although other domains of gp120 are also involved (11, ...co-express CD4 and CCR5 or CXCR4 in a ... See full document
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Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds
... of epitopes after binding of sCD4, such as 17b (27) and KD-247 (11, ...between gp120 and NBD compounds will assist in optimization efforts, as well as in the evaluation of this strategy in more ... See full document
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Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding.
... bound CD4 at a level comparable to that of the wild-type envelope glycoprotein but did not exhibit sCD4- induced shedding of the exterior envelope glycoprotein ...sCD4-induced gp120 shedding to occur ... See full document
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Antigenic Variation within the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120: Effects on Chemokine Receptor Utilization
... and characterization of soluble ...the human embryonic kidney cell line 293 previously infected with vTF7-3, a recombinant vaccinia virus expressing T7 polymerase ...for gp120 levels in a ... See full document
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Fine Mapping of the Interaction of Neutralizing and Nonneutralizing Monoclonal Antibodies with the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120
... monomeric gp120 of human immunodeficiency virus type 1 to systematically identify residues important for gp120 recognition by neutralizing and nonneutralizing monoclonal ... See full document
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Characterization of the Outer Domain of the gp120 Glycoprotein from Human Immunodeficiency Virus Type 1
... very neutralization-resistant primary isolates, in a single-round entry assay (data not ...the gp120 subunit and the gp120 outer domain in the rabbits immunized with the gp140(-/FT) ...meric ... See full document
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Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1.
... for human immunodeficiency virus (HIV). The binding site for the surface glycoprotein of HIV type 1 (HIV-1), gp120, has been mapped to the C * -C ( region of domain ... See full document
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Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody.
... ROBINSON' Received 23 August 1990/Accepted 12 October 1990 A human monoclonal antibody designated 15e is reactive with the envelope glycoprotein gpl20 of multiple isolates of human immun[r] ... See full document
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Generation and characterization of monoclonal antibodies to the putative CD4-binding domain of human immunodeficiency virus type 1 gp120.
... 3579-3585 0022-538X/89/093579-07$02.00/0 Copyright © 1989, American Society for Microbiology Generation and Characterization of Monoclonal Antibodies to the Putative CD4-Binding Domain o[r] ... See full document
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Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120.
... The binding site for 19b spans both sides of the V3 loop and involves amino acids -I----G--FY-T ...influence binding of 19b to monomeric gp120 (52). All of the sequenced virus strains in the ... See full document
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