[PDF] Top 20 Characterization of nerve growth factor-dependent herpes simplex virus latency in neurons in vitro.
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Characterization of nerve growth factor-dependent herpes simplex virus latency in neurons in vitro.
... Expression of infectious virus during the establishment of latent infections and during the reactivation of HSV after NGF deprivation from neuronal cultures inoculated with HSV in the pr[r] ... See full document
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Characterization of a Nerve Growth Factor-Inducible Cellular Activity That Enhances Herpes Simplex Virus Type 1 Gene Expression and Replication of an ICP0 Null Mutant in Cells of Neural Lineage
... with differentiation of PC12 cells is the formation of neurite- like processes. Not only is neurite formation induced by NGF and FGF, but neurite formation can also be induced by com- bined treatment with EGF and KCl ... See full document
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The herpes simplex virus type 1 latency-associated transcript promoter is activated through Ras and Raf by nerve growth factor and sodium butyrate in PC12 cells.
... infection, herpes simplex virus (HSV) repli- cates initially in epithelial cells of the ocular and oral-facial ...of neurons at the site of infection, and virus is transported ... See full document
9
Differential effects of nerve growth factor and dexamethasone on herpes simplex virus type 1 oriL- and oriS-dependent DNA replication in PC12 cells.
... oriS- dependent DNA ...in vitro tests of mutants lacking either oriL or both copies of oriS have shown that the two origins can substitute for one another (23, ...neurotropic virus and establishes ... See full document
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Herpes Simplex Virus Type 1 Promoter Activity during Latency Establishment, Maintenance, and Reactivation in Primary Dorsal Root Neurons In Vitro
... which latency is established, the real and perceived asynchronicity of these molecular events in vivo, and the difficulty of addressing latency-dedicated func- tions of viral gene products that have a role ... See full document
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Identification of cis-acting sequences in the promoter of the herpes simplex virus type 1 latency-associated transcripts required for activation by nerve growth factor and sodium butyrate in PC12 cells.
... The radiolabeled 2 170/ 2 141 oligonucleotide probe was in- cubated with nuclear extracts from untreated and NGF-treated cells in the presence of excess homologous probe or mutant probe M1, M2, M3, or M4 (the sequences ... See full document
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Lund Human Mesencephalic (LUHMES) Neuronal Cell Line Supports Herpes Simplex Virus 1 Latency In Vitro
... in vitro models of HSV-1 quiescence or latency employ tumor cell lines that can be differentiated into ...of nerve growth factor (NFG) (5, ...of latency and the fact that these ... See full document
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Nerve growth factor deprivation results in the reactivation of latent herpes simplex virus in vitro.
... Viral latency was stable; inoculation with 0.5 PFU of HSV per cell followed by the addition of anti-HSV serum 5 weeks before anti-NGF treatment resulted in reactivation in 25% of the cul[r] ... See full document
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Herpes Simplex Virus Type 1 Vector-Mediated Expression of Nerve Growth Factor Protects Dorsal Root Ganglion Neurons from Peroxide Toxicity
... the latency- active promoter 2 (LAP2) ...DRG neurons at 14 ...DRG neurons at 14 days ...HSV latency at 4 ...infected neurons in ... See full document
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Inducible Cyclic AMP Early Repressor Produces Reactivation of Latent Herpes Simplex Virus Type 1 in Neurons In Vitro
... Herpes simplex virus type 1 (HSV-1) establishes a latent infection in neurons of the peripheral nervous ...to latency-associated transcripts ...latent virus to periodically ... See full document
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The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... in neurons LAT might suppress ICP0 by an antisense mechanism and that this might be involved in the establishment and maintenance of latency (25, ... See full document
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In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... protect neurons from apoptosis (9, 19) or cell death (20) during the later stages of the acute infection, as the virus establishes neuronal ...after latency had been established. Adeno-associated ... See full document
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Entry of Herpes Simplex Virus Type 1 into Primary Sensory Neurons In Vitro Is Mediated by Nectin-1/HveC
... The virus was added to serum- treated cells for 1 h to allow adsorption, and then the inoculum was replaced with medium supplemented with 100 M acyclo- ... See full document
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Expression and in vitro Characterization of Herpes Simplex Virus 1 (HSV-1) ORF P Protein
... erpes simplex virus 1 (HSV-1) unspliced 8.3 latency associated transcript (LAT), which located in the long repeat sequences, has been shown to contain at least 16 open reading frames (ORF: A-P) ... See full document
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The fibroblast growth factor receptor is not required for herpes simplex virus type 1 infection.
... In this case, we found that a soluble FGF receptor fragment was able to bind bFGF directly and inhibited bFGF binding and receptor activation; however, the soluble receptor did not inhib[r] ... See full document
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PrPc Expression Influences the Establishment of Herpes Simplex Virus Type 1 Latency
... In our study we have utilized the TUNEL assay, which de- tects fragmented DNA, to measure apoptosis. It has been suggested that TUNEL identifies cells that have undergone not only apoptosis but also necrosis and ... See full document
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Herpes Simplex Virus Type 1 Enters Human Epidermal Keratinocytes, but Not Neurons, via a pH-Dependent Endocytic Pathway
... Tyrosine kinase activity is necessary for endocytic entry of HSV in keratinocytes. Endocytosis is a tightly regulated pro- cess involving host kinase activities. It was previously shown that the lipid kinase, ... See full document
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Herpes simplex virus infection can occur without involvement of the fibroblast growth factor receptor.
... 824 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Basic fibroblast growth factor bFGF has been reported to block uptake of herpes simplex virus type 1 HSV-1 and plaqu[r] ... See full document
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Control of Herpes Simplex Virus Replication Is Mediated through an Interferon Regulatory Factor 3-Dependent Pathway
... Several non-mutually exclusive possibilities exist to explain this persistent defect in the ability of IRF-3 ⫺/⫺ BMDCs to control HSV-1 replication (Fig. 8). One possibility is a defec- tive autocrine and paracrine IFN ... See full document
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Prolongation of herpes simplex virus latency in cultured human cells by temperature elevation.
... As long as the cultures were maintained at 39.5 to 40'C up to at least 128 days, HSV-2 was latent and infectious virus was undetectable.. If the temperature was reduced to 370C at any ti[r] ... See full document
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