[PDF] Top 20 Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH
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Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH
... microarray analysis rou- tinely detects abnormalities smaller than 500 kb that dis- rupt clinically significant genes and have clear phenotypic impact (Figure 4); conversely, numerous examples of common ... See full document
14
Whole genome DNA copy number changes identified by high density oligonucleotide arrays
... DNA copy number are one of the hallmarks of the genetic instability common to most human ...micro- array-based methods have been used to identify chromosomal gains and losses; however, they are ... See full document
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Original Article Whole genome amplification effect on segmental copy-number changes and copy-number neutral loss of heterozygosity analysis by oligonucleotide-based array-comparative genomic hybridization in human myeloma cell line
... entire genome [7, ...(RFLP) analysis [8], Southern blotting analysis [8], quantitative real-time PCR [8, 16], high resolu- tion melting analysis [17-19], CGH [8, 20], aCGH [21-24] or ... See full document
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The clinical application of array CGH for the detection of chromosomal defects in 20,126 unselected newborns
... Array Comparative Genomic Hybridization (CGH) was developed as a screening strategy for detecting genome- wide DNA copy number changes and many groups have studied the clinical ... See full document
5
Progression of naive intraepithelial neoplasia genome to aggressive squamous cell carcinoma genome of uterine cervix
... using whole-exome sequencing analysis ...by whole-exome sequencing and array-comparative genomic hybridization (array-CGH) and found that CIN genomes harbored fewer ... See full document
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Comparison of genome-wide array genomic hybridization platforms for the detection of copy number variants in idiopathic mental retardation
... AGH whole genome tech- nologies [18-20], and most are retrospective and limited to pathogenic ...ome-wide oligonucleotide platforms – Affymetrix 500 K, Agilent 244 K and NimbleGen 385 K – to assess ... See full document
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The use of ultra-dense array CGH analysis for the discovery of micro-copy number alterations and gene fusions in the cancer genome
... for analysis into Genomic Workbench, standard edition ...Aberration Detection Method 2 (ADM-2) algorithm to identify DNA copy number ...the array plots led to the rejection of several ... See full document
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Clinical implementation of whole-genome array CGH as a first-tier test in 5080 pre and postnatal cases
... technologies. Array CGH has successfully detected DNA copy number changes, and several groups have studied the clinical application of this technology in both prenatal and postnatal samples ... See full document
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Whole genome amplification and its impact on CGH array profiles
... by array CGH, because the resolution of CGH is lower than array ...of array CGH studies have compared test wgaDNA to reference wgaDNA [14,20,23], which is the most likely ... See full document
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A survey of analysis software for array-comparative genomic hybridisation studies to detect copy number variation
... Copy number variants (CNVs) are DNA sequences that are present in different amounts among indi- viduals in a ...population. Copy number differences can confer a change in gene expression, ... See full document
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Genome-wide array-CGH analysis reveals YRF1 gene copy number variation that modulates genetic stability in distillery yeasts
... established genome of brewer’s and wine yeast strains, the comprehensive evaluation of genomic features of distillery strains is ...and array-based comparative genomic hybridization ...gene ... See full document
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Copy number alterations detected by whole-exome and whole-genome sequencing of esophageal adenocarcinoma
... the genome into small contigu- ous regions using sliding ...the copy number ...the copy num- ber ratios, and the positions with nonzero coefficients were considered as change ...lute ... See full document
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Chromosome 15q11-q13 copy number gain detected by array-CGH in two cases with a maternal methylation pattern
... Genetic analysis determined that the genes within the regions that were duplicated in one or both of the patients are significantly associated with identified functional net- ... See full document
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Genomic amplification of 9p24.1 targeting JAK2 PD-L1 , and PD-L2 is enriched in high-risk triple negative breast cancer
... to CGH arrays (Agilent Technologies, Santa Clara, CA) for 40 hours in a rotating 65°C ...aberration detection algorithm (ADM2) ...the number of these ...the number of probes in the ... See full document
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Array-based comparative genomic hybridization for genomic-wide screening of DNA copy number alterations in aggressive bone tumors
... The incidence of aggressive changes of bone tissue is low. Similar to other solid tumors, malignant changes are characterized by high propensity for me- tastasis. Metaphase CGH studies have identified fre- quent ... See full document
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Whole Genome Sequence and Comparative Genomics Analysis of Multi drug Resistant Environmental Staphylococcus epidermidis ST59
... Whole Genome Sequence and Comparative Genomics Analysis of Multi drug Resistant Environmental Staphylococcus epidermidis ST59 Whole genome sequence and comparative genomics analysis of multi drug resi[.] ... See full document
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Copy number and gene expression differences between African American and Caucasian American prostate cancer
... had copy number gain at ...between copy number gain and gene overexpression, most notably in genes mapping ...of copy number gains at ... See full document
9
Array CGH and breast cancer
... Thus, CGH has helped to uncover some of the intrinsic complexity of tumour chromosome behaviour, which is still poorly ...using comparative expressed sequence hybridization (CESH) ...and CGH at ... See full document
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Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy
... Several other genes frequently deleted in patients with MSA, such as HCN2, MADCAM1, and FGF22 , are also expressed in nervous tissue. HCN2 contributes to spontaneous rhythmic activity in the external seg- ment of the ... See full document
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Deciphering the pathogenic consequences of chromosomal aberrations in human genetic disease
... large number of healthy individuals, and (iii) the segregation of the CNV in the family, for example, de novo imbalances are consid- ered to be likely pathogenic whereas those inherited from an apparently healthy ... See full document
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