[PDF] Top 20 HLA Compatibility Requirements for CD8+-T-Cell-Mediated Suppression of Human Immunodeficiency Virus Replication
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HLA Compatibility Requirements for CD8+-T-Cell-Mediated Suppression of Human Immunodeficiency Virus Replication
... different HLA relatedness were ex- perimentally infected with HIV-1 and used as target cells (Ta- ble ...endogenous virus is not released into culture at appreciable levels until 12 days poststimulation ... See full document
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Noncytotoxic Suppression of Human Immunodeficiency Virus Type 1 Transcription by Exosomes Secreted from CD8+ T Cells
... other cell types describe a specific enrichment of MHC class II molecules and proteins of the tetraspanin family such as CD9, CD63, and CD81 (14, ...Noncytolytic suppression of HIV-1 by secreted membrane ... See full document
11
Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine Containing Multiple HLA A2 HIV CD8+ Cytotoxic T-Cell Epitopes
... cytotoxic T lymphocytes (CTL) have a role in pre- venting or limiting (i) initial human immunodeficiency virus (HIV) infection (36) and (ii) progression to AIDS ... See full document
6
Different Effects of Nef-Mediated HLA Class I Down-Regulation on Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Cytolytic Activity and Cytokine Production
... HIV-1 clones. An infectious proviral clone of HIV-1, pNL-432, and its mu- tants, pNL-Xh (containing a frameshift at a XhoI site within the nef gene) and pNL-M20A (containing a substitution of Ala for Met at residue 20 of ... See full document
9
PolyI polyC12U mediated inhibition of loss of alloantigen responsiveness viral replication in human CD4+ T cell clones exposed to human immunodeficiency virus in vitro
... suppression. The mismatched double-stranded RNA blocked HIV-associated particulate reverse transcriptase activity and viral-mediated cytopathic effects. Also, polyI.polyC12U preserved the alloreactivity of ... See full document
10
Differential effect of the immunomodulatory hormone somatostatin on replication of human immunodeficiency virus type 1 in CD4+ and CD8+ T lymphocytes.
... of T cells ...HIV-1 replication and cell ...presumably mediated by distinct ...and CD8 1 lymphocytes could presumably help to prevent the expression of the HIV-1 genome following ... See full document
7
Suppression of Acute Anti-Friend Virus CD8+ T-Cell Responses by Coinfection with Lactate Dehydrogenase-Elevating Virus
... Friend virus (FV) and lactate dehydrogenase-elevating virus (LDV) are endemic mouse viruses that can cause long-term chronic infections in ...FV-specific CD8 ⴙ T-cell responses during ... See full document
11
Functional Consequences of Human Immunodeficiency Virus Escape from an HLA-B*13-Restricted CD8+ T-Cell Epitope in p1 Gag Protein
... Viral escape in B*13-RI9 affects in vitro HIV fitness. Since previous studies have shown the potential benefit of Gag-spe- cific CTL responses that impose structural constraints on HIV by driving the selection of ... See full document
8
In Vitro Suppression of Human Immunodeficiency Virus Type 1 Replication by Measles Virus
... replicating virus (10, ...36), CD8 ⫹ T-cell antiviral factor (17, 27), type 1/2 interferons (24), and the cytokines IL-10, IL-13, IL-16, and IL-18 (1, 2, ...Furthermore, suppression of ... See full document
9
CD8+-Cell Antiviral Factor Activity Is Not Restricted to Human Immunodeficiency Virus (HIV)-Specific T Cells and Can Block HIV Replication after Initiation of Reverse Transcription
... viral replication. Supernatants from the 1.6-EBV line were then demonstrated not to affect viral entry on CEM cells (Ta- ble 1). Furthermore, we observed that the number of LTR copies detected in infected CEM ... See full document
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Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+-T-Cell Responses for Groups of HIV-1-Infected Individuals with Different HLA-B*35 Genotypes
... frequency mediated through all the HLA genes present in each individual, instead of those restricted only by either the B*35-Px or -PY ...other HLA types present in addition to ...at HLA-B ... See full document
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Viral suppression of multiple escape mutants by de novo CD8+T cell responses in a human immunodeficiency virus 1 Infected elite suppressor
... the virus by the CTL response to the wild type TW10 epitope, as shown in Figure ...TW10-specific T cell receptors in patients who develop rare alternate mutations in this epitope may be ... See full document
7
Specific CD8+ T Cell Responses Correlate with Control of Simian Immunodeficiency Virus Replication in Mauritian Cynomolgus Macaques
... of human and simian immunodeficiency viruses (HIV and ...I-restricted CD8 ⴙ T cells, but it is not clear whether particular CD8 ⴙ T cell responses or a broad repertoire of ... See full document
9
Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T Lymphocytes
... of cell surface CD4 molecules, downregulation of cell surface major histo- compatibility complex (MHC) class I molecules, enhancement of viral infectivity, and modulation of T-cell ... See full document
9
Emergence of Polyfunctional CD8+ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy
... of CD8 ⫹ T cells, we first measured the expression of IL-7R ␣ on CD8 ⫹ T cells from study and control group patients ...effector T cells with high expression levels of IL-7R ␣ ... See full document
14
A semiquantitative assay for CD8+ T-cell-mediated suppression of human immunodeficiency virus type 1 infection.
... ciency virus type 1 (anti-HIV-1) suppressive activity of CD8 1 T ...purified CD8 1 T ...restricted. Suppression of HIV-1 infection by CD8 1 T cells was consistently ... See full document
7
Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms.
... inhibitors of M-tropic strains of HIV-1 (9). We next assessed whether CTL produce these factors. Resting CTL clones pro- duced very little of these substances (,2 ng/ml), but activation by CD3 cross-linking induced their ... See full document
9
Evidence of CD8+ T-Cell-Mediated Selective Pressure on Human Immunodeficiency Virus Type 1 nef in HLA-B*57+ Elite Suppressors
... Phylogenetic analysis of HIV-1 nef from plasma and resting CD4 ⴙ T cells. Raw nef sequences from plasma and resting CD4 ⫹ T cells, along with an M group ancestral sequence, were aligned using Gene Cutter ... See full document
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Natural Suppression of Human Immunodeficiency Virus Type 1 Replication Is Mediated by Transitional Memory CD8+ T Cells
... cells, CD8 ⫹ cells differing in their levels of coexpression of CD45RA CD62L, CD45RA CCR7, CD11b CD57, CD11b CD28, CD57 CD28, and CD45RA CD27 CD28 were assessed ...of CD8 ⫹ cells that differed in their ... See full document
10
CD8+ T-Cell-Mediated Cross-Clade Protection in the Genital Tract following Intranasal Immunization with Inactivated Human Immunodeficiency Virus Antigen Plus CpG Oligodeoxynucleotides
... of virus to susceptible corecep- tor-bearing ...cytotoxic T-cell activity against infected host ...of T-cell help, using it in prophylactic or therapeutic vaccines may be ...and ... See full document
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