[PDF] Top 20 Conserved Changes in Envelope Function during Human Immunodeficiency Virus Type 1 Coreceptor Switching
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Conserved Changes in Envelope Function during Human Immunodeficiency Virus Type 1 Coreceptor Switching
... that type as pure X4 viruses using similar entry assays (5, ...observed during adaptation of HIV-1 IIIB to replication in infected laboratory workers (33), as well as lab- oratory adaptation of ... See full document
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Human Immunodeficiency Virus Type 1 Coreceptor Switching: V1/V2 Gain-of-Fitness Mutations Compensate for V3 Loss-of-Fitness Mutations
... for coreceptor switching than the ob- served ...of coreceptor switching must have included other more deleterious muta- tions prior to the introduction of these three ...an envelope ... See full document
9
Truncation of the Cytoplasmic Domain Induces Exposure of Conserved Regions in the Ectodomain of Human Immunodeficiency Virus Type 1 Envelope Protein
... the virus or the ...influenza virus hemagglutinin protein, for ex- ample, play an important role in hemagglutinin oligomeriza- tion and trimer stability (12, ...conformational changes needed for ... See full document
9
Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity.
... 5007-5012 0022-538X/91/095007-06$02.00/0 Copyright © 1991, American Society for Microbiology Effects of Changes in gpl20-CD4 Binding Affinity on Human Immunodeficiency Virus Type 1 Envel[r] ... See full document
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SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement
... SOSIP changes on Env conformation by comparing the antigenic profile of this mutant to that of its wild-type ...SOSIP changes decreased recognition by State 1-preferring ...SOSIP changes ... See full document
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Subunit Stoichiometry of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers during Virus Entry into Host Cells
... Human immunodeficiency virus type 1 (HIV-1) encodes a gp160 envelope precursor ...HIV-1 envelope gly- coprotein spikes mature by trimerization, ... See full document
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Comparative Immunogenicity of Subtype A Human Immunodeficiency Virus Type 1 Envelope Exhibiting Differential Exposure of Conserved Neutralization Epitopes
... sub- type A HIV-1 Envs, with very different neutralization pheno- types to directly address (i) whether HIV-1 Env variants that expose conserved neutralization epitopes can lead to enhanced ... See full document
12
Chemokine Coreceptor Usage by Diverse Primary Isolates of Human Immunodeficiency Virus Type 1
... the virus represented the genet- ically divergent viral strains within the M group or the even more divergent set of viruses within the O ...that conserved amino acid residues within the CCR5 binding site ... See full document
6
Sequential CD4-Coreceptor Interactions in Human Immunodeficiency Virus Type 1 Env Function: Soluble CD4 Activates Env for Coreceptor-Dependent Fusion and Reveals Blocking Activities of Antibodies against Cryptic Conserved Epitopes on gp120
... Env function is that CD4 binding activates Env for functional interaction with corecep- tor on target cells; membrane fusion then ...Figure 1 shows the results of experiments in which effector cells ... See full document
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Functional Mimicry of a Human Immunodeficiency Virus Type 1 Coreceptor by a Neutralizing Monoclonal Antibody
... an amino acid (residue 440) from the fourth conserved region of gp120. These changes in gp120 have been shown to alter chemokine receptor preference (4, 8). The HXBc2(YU2V3) gly- coprotein, which contains ... See full document
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Enhancing the Proteolytic Maturation of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins
... 95). Changes in the gp120 vari- able loops (72, 85), elsewhere in Env (19, 51, 84, 88, 94), and at residues proximal to the cleavage site (2, 29, 33, 84) can all affect Env cleavage efficiency, usually ...a ... See full document
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Human immunodeficiency virus type 1 and 2 envelope glycoproteins oligomerize through conserved sequences.
... The HIV-2 a-helical sequence mediated hetero-oligomer- ization between HIV-2 and HIV-1 Env despite amino acid differences in positions predicted to form the interface of a coiled-coil of parallel a-helices (5). ... See full document
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Compartmentalization of Surface Envelope Glycoprotein of Human Immunodeficiency Virus Type 1 during Acute and Chronic Infection
... surface envelope glycopro- tein of HIV-1 between peripheral blood and tissues during the acute and chronic phases of ...generated during the amplification step ...(patients 1 to 5), the ... See full document
9
The Crown and Stem of the V3 Loop Play Distinct Roles in Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Interactions with the CCR5 Coreceptor
... CCR5 coreceptor function, including anti-CCR5 MAbs and small molecules, have been shown to block gp120 binding to CCR5 without affecting the gp120-Nt interaction (12, 19, ...CXCR4 coreceptor ... See full document
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Consistent Patterns of Change during the Divergence of Human Immunodeficiency Virus Type 1 Envelope from That of the Inoculated Virus in Simian/Human Immunodeficiency Virus-Infected Macaques
... the virus more susceptible to neutral- ization (42). Mapping the conserved PNGs identified in this study onto the HIV-1 gp120 core demonstrated that most of the 19 highly conserved sites are ... See full document
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Evolution of the Human Immunodeficiency Virus Type 1 Envelope during Infection Reveals Molecular Corollaries of Specificity for Coreceptor Utilization and AIDS Pathogenesis
... of human immunodeficiency virus type 1 infection is associated with a shift in the target cell population, driven by variability in coreceptor utilization resulting from ... See full document
15
CCR8 on Human Thymocytes Functions as a Human Immunodeficiency Virus Type 1 Coreceptor
... X4R5 envelope-expressing ...could function as an HIV-1 coreceptor in primary hu- man ...R5 envelope- expressing cells was detected, as previously described ...the envelope from ... See full document
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No Selection for CCR5 Coreceptor Usage during Parenteral Transmission of Macrophagetropic Syncytium-Inducing Human Immunodeficiency Virus Type 1
... biological virus clones were available from a blood sample obtained from donor ACH704 8 months before the moment of ...biological virus clones had the NSI phenotype and five had the SI phenotype, as ... See full document
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Physiological Levels of Virion-Associated Human Immunodeficiency Virus Type 1 Envelope Induce Coreceptor-Dependent Calcium Flux
... cell function and even induce apoptosis (2, 6, 16), it is possible that such X4-tropic virion signaling may play a role in bystander effects in infected patients, contributing to the immunodeficiency ... See full document
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Coreceptor Tropism Can Be Influenced by Amino Acid Substitutions in the gp41 Transmembrane Subunit of Human Immunodeficiency Virus Type 1 Envelope Protein
... sarcoma/leukosis virus TM protein, corresponding to the HR1 domain of HIV-1 TM, resulted in expanded cellular tropism ...ence coreceptor-mediated tropism. In addition to coreceptor ... See full document
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