[PDF] Top 20 Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replication.
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Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replication.
... FIG. 1. Conserved sequences in the carboxyl terminus of retroviral ...the carboxyl terminus of HIV-1 IN, residues 184 to ...only conserved in the ... See full document
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Irreversible Inhibition of Human Immunodeficiency Virus Type 1 Integrase by Dicaffeoylquinic Acids
... Human immunodeficiency virus type 1 (HIV-1) and other retroviruses require integration of a double- stranded DNA copy of the RNA genome into the host cell chromosome for ... See full document
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Lys-34, Dispensable for Integrase Catalysis, Is Required for Preintegration Complex Function and Human Immunodeficiency Virus Type 1 Replication
... is essential for proper PIC maturation and/or trafficking. Because HIV-1 IN interacts with a variety of human cell pro- teins (44), we and others previously proposed that the inability to interact ... See full document
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Human Immunodeficiency Virus Type 1 Escape Is Restricted When Conserved Genome Sequences Are Targeted by RNA Interference
... the human immunodeficiency virus type 1 (HIV-1) through stable expression of short-hairpin RNAs ...when essential and highly conserved sequences are targeted ... See full document
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Monoclonal Antibodies against the Minimal DNA-Binding Domain in the Carboxyl-Terminal Region of Human Immunodeficiency Virus Type 1 Integrase
... Integration of a DNA copy of the viral RNA genome into a chromosome of the host cell is an essential step in the retro- viral life cycle (4, 21, 41). The viral enzyme integrase (IN) catalyzes the process in ... See full document
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Conserved, N-Linked Carbohydrates of Human Immunodeficiency Virus Type 1 gp41 Are Largely Dispensable for Viral Replication
... The extracellular domain of gp41 consists of an amino-ter- minal fusion domain, N- and C-terminal heptad repeats, a short disulfide loop, and a tryptophan-rich domain (Fig. 1) (11). Sequential binding of gp120 to ... See full document
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Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.
... in sequences surrounding the ...Pst 1) (nt 1405 to 1422; 59-CCATTCTGCAGCTTCCTC-39) to specifically amplify sequences in regard to each of these ...59 terminus of the R region ... See full document
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Targeting Human Immunodeficiency Virus (HIV) Type 2 Integrase Protein into HIV Type 1
... retroviruses, human immunodeficiency virus type 1 (HIV-1) and HIV-2 integrate a DNA copy of their RNA genome into the host cell’s ...the integrase (IN) protein ...highly ... See full document
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Oligomerization within Virions and Subcellular Localization of Human Immunodeficiency Virus Type 1 Integrase
... C terminus of ...C terminus of IN, we used a primer encoding part of the sequence of the fusion epitope in its 59 portion and complementary to the C-terminal sequence of IN in the 39 portion (primer HA1 for ... See full document
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Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.
... the human immunodeficiency virus type 1 (HIV-1) integrase (IN) catalytic domain were analyzed for interactions at the enzyme active ...in human cell lines. Each of ... See full document
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Disulfide-Linked Integrase Oligomers Involving C280 Residues Are Formed In Vitro and In Vivo but Are Not Essential for Human Immunodeficiency Virus Replication
... mutant virus bearing the IN C280S mutation was constructed, and the oligomeric status of its IN was compared to that of the wild-type ...mutant virus, respectively, were used to transfect HeLa ... See full document
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Role of the DIS hairpin in replication of human immunodeficiency virus type 1.
... of human immunodeficiency virus type 1 consists of a noncovalently linked dimer of two identical, unspliced RNA ...the type of interaction is termed loop-loop ...different ... See full document
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Human Immunodeficiency Virus Type 1 Replication in the Absence of Integrase-Mediated DNA Recombination: Definition of Permissive and Nonpermissive T-Cell Lines
... with human T-cell leukemia virus type 1 (HTLV-1), we considered the possibility that preexisting HTLV-1 IN might complement the class I HIV-1 integration defects in these ... See full document
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Conserved Footprints of APOBEC3G on Hypermutated Human Immunodeficiency Virus Type 1 and Human Endogenous Retrovirus HERV-K(HML2) Sequences
... in sequences derived from HIV-1-infected patients for which no parental sequence is ...hypermutated sequences should be compared with their parental sequence ...consensus sequences derived ... See full document
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Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residues.
... The role of these residues in IN function has been investigated in vitro, using deletion and substitution mutants of IN protein from human immunodeficiency virus type 1 HIV-1 11, 14, 30,[r] ... See full document
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Genetic Analyses of Conserved Residues in the Carboxyl-Terminal Domain of Human Immunodeficiency Virus Type 1 Integrase
... of 1% bovine serum albumin and precleared with 50 l protein A-Sepharose CL-4B beads (Amer- sham Pharmacia Biotech AB, Uppsala, Sweden) hydrated in phosphate-buffered ...PAGE). Virus particles were pelleted ... See full document
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Posttranslational Acetylation of the Human Immunodeficiency Virus Type 1 Integrase Carboxyl-Terminal Domain Is Dispensable for Viral Replication
... an integrase mutant (IN D116A) lack- ing all catalytic activity and associated with dramatic increases in the accumulation of 2-LTR circles (9, ...highly conserved catalytic RT motif YMDD (33, 34), and the ... See full document
6
Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.
... be replication defective because the mutation di- minishes IN activity in vitro, many were found to exhibit de- fects at other stages of the viral replication ...wild-type virus following ... See full document
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A conserved hairpin motif in the R-U5 region of the human immunodeficiency virus type 1 RNA genome is essential for replication.
... the human immunodeficiency virus (HIV) RNA genome contains multiple hairpin ...well conserved among HIV and simian immunodeficiency virus isolates, despite consider- able ... See full document
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Human immunodeficiency virus type 1 and 2 envelope glycoproteins oligomerize through conserved sequences.
... functionally conserved determinant within gp41 ...influenza virus hemagglutinin ...C terminus of the Escherichia coli maltose-bind- ing protein results in tetramers ...leukemia virus TM is ... See full document
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