[PDF] Top 20 Consistent Inhibition of HIV-1 Replication in CD4+ T Cells by Acyclovir without Detection of Human Herpesviruses
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Consistent Inhibition of HIV-1 Replication in CD4+ T Cells by Acyclovir without Detection of Human Herpesviruses
... 2. Inhibition of HIV-1 replication and detection of ACVTP in herpesvirus-negative CD4 ⫹ T cells from cord ...(A) Acyclovir inhibits HIV-1 ... See full document
5
Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes
... CD8 T cells, marked inhibition of replication was observed at CD8/CD4 T-cell ra- tios of 1:1 and 1:4 ...CD8 T cells directly isolated from ... See full document
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Inhibition of Human Immunodeficiency Virus Type 1 Replication in Primary CD4+ T Lymphocytes, Monocytes, and Dendritic Cells by Cytotoxic T Lymphocytes
... of HIV-1 in these cell types was less efficient than in lymphocytes despite a 10-fold higher initial input of virus ...viral replication in either monocytes ...some inhibition in B14 monocytes ... See full document
5
Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo.
... time, cells were cotransfected with murine leukemia virus long term repeat-driven luciferase expression plas- mid to normalize the transfection ...COS cells were denatured in reducing sample buffer, ... See full document
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Inhibition of HIV-1 Integration in Ex Vivo-Infected CD4 T Cells from Elite Controllers
... RV144 HIV-1 vaccine study (13), correlates of immune protection against HIV-1 remain poorly understood and continue to represent a high-priority area of research ...clear HIV-1 ... See full document
5
Regulation of cyclin T1 during HIV replication and latency establishment in human memory CD4 T cells
... of HIV replication on some CD4 T cell functions shown in ...decreasing CD4 expression, CycT1 levels remained mostly unaffected by HIV replication when comparing infected ... See full document
16
Regulation of Cyclin T1 and HIV-1 Replication by MicroRNAs in Resting CD4+ T Lymphocytes
... The replication of integrated human immunodeficiency virus type 1 (HIV-1) is dependent on the cellular cofactor cyclin T1, which binds the viral Tat protein and activates the RNA ... See full document
9
Stimulation of HIV-1 Replication in Immature Dendritic Cells in Contact with Primary CD4 T or B Lymphocytes
... primary CD4 T or B lymphocytes were added at different time points, the detection of an increased viral mRNA level after lymphocyte addition is consistent with the stimulation of an early step ... See full document
11
Cycling Memory CD4+ T Cells in HIV Disease Have a Diverse T Cell Receptor Repertoire and a Phenotype Consistent with Bystander Activation
... whereby human immunodefi- ciency virus (HIV) infection results in progressive immune deficiency are incompletely ...circulating CD4 ⫹ T cells is the hallmark of immune defi- ciency in ... See full document
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Impact of sustained RNAi mediated suppression of cellular cofactor Tat SF1 on HIV 1 replication in CD4+ T cells
... bits HIV-1 replication in both TZM-bl reporter cells and CD4+ T cell-derived SupT1 ...TZM-bl cells [18], although we further demonstrated that the inhibitory effect on ... See full document
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Suppression of HIV-1 Infection by APOBEC3 Proteins in Primary Human CD4+ T Cells Is Associated with Inhibition of Processive Reverse Transcription as Well as Excessive Cytidine Deamination
... of human immunodeficiency virus type 1 (HIV-1) promotes viral replication by downregulation of the cell-en- coded, antiviral APOBEC3 ...the inhibition of viral reverse tran- ... See full document
10
Human Mucosal Mast Cells Capture HIV-1 and Mediate Viral trans-Infection of CD4+ T Cells
... mast cells is dependent on the surface-bound majority of viral particles, as the removal of surface-bound viruses by trypsin treatment dramatically impairs FIG 2 Intestinal mucosal mast cell-mediated ... See full document
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Human Endothelial Cells Enhance Human Immunodeficiency Virus Type 1 Replication in CD4+ T Cells in a Nef-Dependent Manner In Vitro and In Vivo
... Infected CD4 ⴙ T cells are the primary sites of human immunodeficiency virus type 1 (HIV-1) replication in ...antigen-presenting cells (APCs), such as ... See full document
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SAMHD1: a new contributor to HIV 1 restriction in resting CD4+T cells
... restricts HIV-1 infection in rest- ing CD4 + T-cells by limiting viral cDNA synthesis via depleting the intracellular dNTP pool, at least in part ...SAMHD1-mediated HIV-1 ... See full document
5
Modelling the dynamics of CD4+ T cells with and without delay
... many of the symptoms of AIDS seen clinically; the long latency period, low levels of free virus in the body, and the depletion of CD4+ T-cells. They defined the model by considering four ... See full document
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SAMHD1 restricts HIV 1 reverse transcription in quiescent CD4+T cells
... resting T-cells, as it has been demonstrated for myeloid cells ...full-length HIV-1 DNA in un- stimulated CD4+ T-cells was determined by quantitative ...resting ... See full document
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Inhibition of Human Immunodeficiency Virus Type 1 gp120 Presentation to CD4 T Cells by Antibodies Specific for the CD4 Binding Domain of gp120
... to T cells by preventing gp120 binding to CD4 on the surfaces of APCs and thereby inhibiting its ...to CD4 on the APC sur- faces. To examine whether gp120 binding to CD4 on APCs is ... See full document
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Low level HIV 1 replication and the dynamics of the resting CD4+T cell reservoir for HIV 1 in the setting of HAART
... viral replication consistent with patient data do not affect the decay rate of the latent reservoir In the previous sections we have shown that a threshold of viral replication is necessary for ... See full document
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Discordance between Frequency of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Producing CD4+ T Cells and HIV-1-Specific Lymphoproliferation in HIV-1-Infected Subjects with Active Viral Replication
... of HIV-1 RNA/ml of ...three HIV-1 antigens tested, PBMC proliferative responses to HIV-1 p24 in the HIV-1-infected cohort differed the most (P ⬍ ...the HIV- ... See full document
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HIV 1 infection impairs cell cycle progression of CD4+ T cells without affecting early activation responses
... in cells from HIV-infected patients (10–12), and this has been correlated with proliferation failure (11, ...in cells from HIV-infected subjects and, consequently, lead to proliferation ... See full document
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