[PDF] Top 20 Cooperative effects of the human immunodeficiency virus type 1 envelope variable loops V1 and V3 in mediating infectivity for T cells.
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Cooperative effects of the human immunodeficiency virus type 1 envelope variable loops V1 and V3 in mediating infectivity for T cells.
... the V1 and V3 loops of the enve- lope protein can occur to allow infection of certain cell ...of virus having delayed kinetics in T-cell ...the T-cell line-tropic strain HXB2 and ... See full document
7
A Global Neutralization Resistance Phenotype of Human Immunodeficiency Virus Type 1 Is Determined by Distinct Mechanisms Mediating Enhanced Infectivity and Conformational Change of the Envelope Complex
... of human immunodeficiency virus type 1 (HIV-1) MN enve- ...resistant envelope. By IFA cells expressing neutralization sensitive envelope bound MAbs to gp120 ... See full document
9
N-Linked Glycosylation Sites Adjacent to and within the V1/V2 and the V3 Loops of Dualtropic Human Immunodeficiency Virus Type 1 Isolate DH12 gp120 Affect Coreceptor Usage and Cellular Tropism
... The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) is extensively glycosylated, containing approximately 23 asparagine (N)-linked glycosylation sites ... See full document
9
Cooperation of the V1/V2 and V3 Domains of Human Immunodeficiency Virus Type 1 gp120 for Interaction with the CXCR4 Receptor
... Human immunodeficiency virus type 1 (HIV-1) entry is triggered by the interaction of the gp120 envelope glycoprotein with a cellular chemokine receptor, either CCR5 or ... See full document
8
Infectivity and Neutralization of Simian Immunodeficiency Virus with FLAG Epitope Insertion in gp120 Variable Loops
... within variable loop 1 (V1), 2 (V2), or 4 (V4) of the gp120 envelope glycoprotein of simian immunodeficiency virus strain 239 (SIV239) to evaluate the extent to which each ... See full document
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Introduction of Exogenous Epitopes in the Variable Regions of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein: Effect on Viral Infectivity and the Neutralization Phenotype
... their effects on viral neutralization potential have been examined (14, 19, 22, ...V4 loops of all three iso- lates, the V4 loop could theoretically be a good target for vaccine-elicited ...including ... See full document
11
Human Immunodeficiency Virus Type 1 Coreceptor Switching: V1/V2 Gain-of-Fitness Mutations Compensate for V3 Loss-of-Fitness Mutations
... restored infectivity to several mutated V3 regions, including one containing all five V3 mutations observed in the ADA-1 coreceptor switch mutant ...in V1 during evolution to CXCR4 use ... See full document
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Loss of a Single N-Linked Glycan Allows CD4-Independent Human Immunodeficiency Virus Type 1 Infection by Altering the Position of the gp120 V1/V2 Variable Loops
... the envelope glycoproteins responsible for the conversion of a primary, CCR5-using HIV-1 isolate from a virus dependent on the presence of CD4 on the target cells to a virus that no ... See full document
9
Replacement of the V3 Region of gp120 with SDF-1 Preserves the Infectivity of T-Cell Line-Tropic Human Immunodeficiency Virus Type 1
... low infectivity of the NL4-3/SDF1-51 ...meric envelope in the virion than in the ...of envelope in the NL4-3/SDF1-51 virus was slightly lower than that of the NL4-3/WT ...gp120 envelope ... See full document
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Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein.
... with V1 and V2 deleted, recombinant CAT- encoding viruses containing the wild-type, parental DV1/2, and clone ...4.2 envelope glycoproteins were produced in HeLa ...wild-type virus, the ... See full document
5
A Recombinant Sendai Virus Is Controlled by CD4+ Effector T Cells Responding to a Secreted Human Immunodeficiency Virus Type 1 Envelope Glycoprotein
... least 1 month after the completion of immunizations, spleens from control and test mice were taken for CD4 ⫹ T-cell ...Antigen-presenting cells were prepared from naı¨ve mouse spleens by depleting ... See full document
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Adaptation of Subtype A Human Immunodeficiency Virus Type 1 Envelope to Pig-Tailed Macaque Cells
... the V3 loop, which has been shown to be a determinant for increased sensitivity to sCD4 (23, 42, 59), implying that changes to the V3 loop may participate in quaternary interactions in Env that could lead ... See full document
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Follicular Dendritic Cells and Human Immunodeficiency Virus Type 1 Transcription in CD4+ T Cells
... Elmer), and the mixture was incubated at 37°C for 15 min, followed by addition of 20 l of calcium chloride (10 mM). Genomic DNA was digested with RNase- free DNase I (10 l of a 1-mg/ml solution) for 5 min at ... See full document
9
Mapping of independent V3 envelope determinants of human immunodeficiency virus type 1 macrophage tropism and syncytium formation in lymphocytes.
... Human immunodeficiency virus type 1 (HIV-1) strains vary extensively in their ability to infect, fuse, and kill different cell types in vivo and in ...the V3 region of the ... See full document
5
Effects of Genital Tract Inflammation on Human Immunodeficiency Virus Type 1 V3 Populations in Blood and Semen
... templates. V3-HTA was performed with the subtype C probe as described previously ...159-bp V3 sequence as that used for the subtype C probe from a JR-FL molecular subclone (pUC112-1 from Irvin Chen, ... See full document
7
Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity.
... 2 Human Immunodeficiency Virus Type 1 Clones Chimeric for the Envelope V3 Domain Differ in Syncytium Formation and Replication Capacity JEAN-JACQUES DE JONG,1 JAAP GOUDSMIT,1* WILCO KEUL[r] ... See full document
9
Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells.
... Human immunodeficiency virus type 2 (HIV-2), the second AIDS-associated human retrovirus, was isolated and found to be quite common in west Africa (17, 25), and its molecular structure ... See full document
5
Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity in the Absence of Matrix
... inhibit virus production (15, 18), for example by redirect- ing assembly to intracellular membranes, we found that large deletions often actually enhance particle production over wild- type (WT) levels ... See full document
6
Target Cell Cyclophilin A Modulates Human Immunodeficiency Virus Type 1 Infectivity
... HeLa cells were transduced with a retrovirus expressing an shRNA (17) specific for CypA ...known human cyclophilin family members (15) each possess at least five nucleotide mismatches with respect to the ... See full document
9
Assembly, processing, and infectivity of human immunodeficiency virus type 1 gag mutants.
... The two regulatory protein coding regions for tat and rev that are essential for virus replication are intact, and transient expression of HIVgpt in COS7 cells results in assembly and re[r] ... See full document
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