[PDF] Top 20 Correlation of the 4977 bp mitochondrial DNA deletion with human sperm dysfunction
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Correlation of the 4977 bp mitochondrial DNA deletion with human sperm dysfunction
... between deletion proportion and pregnancy or delivery rates per transfer, after either IVF or ...common deletion in a semen sample reduces male fertility affecting mainly the fertiliza- tion efficiency of ... See full document
8
Human Sperm DNA Fragmentation and Its Correlation with Conventional Semen Parameters
... for sperm DNA damage can be fully integrated in routine clinical practice ...of DNA damage such as varicocele (45), repeated ART failure (4), miscar- riage (83), inflammatory processes or genital ... See full document
13
Mitochondrial dysfunction in human pathologies
... The tri-peptide glutathione (g-glutamyl-cyteinyl- glycine) is an endogenous antioxidant of great importance. GSH is required for the maintenance of the thiol redox status of the cell, protection against oxidative damage, ... See full document
23
DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase
... for Mitochondrial DNA Replication—Because the Twinkle helicase is required for human mtDNA replication, we assessed whether Twinkle was able to unwind various uni-, bi-, and tetramolecular G4 ... See full document
21
Recombination in Human Mitochondrial DNA?
... quences of ⵑ16,500 nucleotides each. There are 367 cal treatment of the cases A and B put in materials polymorphic sites and of these 198 are informative and methods. A linear relation between physical and (from Figure ... See full document
8
Altered skeletal muscle (mitochondrial) properties in patients with mitochondrial DNA single deletion myopathy
... of mitochondrial myopathy harborating a predominate type II fiber atrophy ...to mitochondrial dysfunction and the disease-causing mu- tations itself could have induced the present pathologic ...and ... See full document
12
Human sperm mitochondrial function : implications for male (in)fertility
... of human DNA polymerase gamma (POLG), the sole DNA polymerase present in mitochondria, possesses a CAG-repeat region of variable length, which encodes a polyglutamine ...in sperm quality, and ... See full document
196
Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension
... induce more severe disease. Alternatively, factors additional to DNA damage may be required. These could include epigenetic modifications resulting from excess mitochondrial ROS production (53). Modeling ... See full document
18
Human Mitochondrial Transcription Factor A Reduction and Mitochondrial Dysfunction in Hashimoto’s Hypothyroid Myopathy
... h-mtTFA and FT3 (data not shown). No correlation was found with muscle mtDNA/18S rDNA ratio. Discussion We report here the occurrence, in patients with hypothyroid myopathy, of h-mtTFA reduction in skeletal ... See full document
8
Clinical and pathological features of mitochondrial DNA deletion disease following antiretroviral treatment
... ses (patients 3 and 4), mtDNA copy number in muscle was nor- mal but large-scale mtDNA deletions were detected (not shown). Discussion | We describe 4 adults with treated HIV infection and evidence of ... See full document
5
Human mitochondrial DNA replication machinery and disease.
... in mitochondrial disease and not others? Does mtDNA mutation, deletion, and depletion play a role in tissue specific effects? What role do mtDNA polymorphisms play in mitochondrial disease? Do ... See full document
29
In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration
... intraneuronal mitochondrial crowding and accumulation of amyloid-β ...6-bp deletion in the nuclear-encoded pitrilysin metallopeptidase 1 (PITRM1) encoding for a mitochondrial protease involved ... See full document
27
Bulky DNA adducts in human sperm associated with semen parameters and sperm DNA fragmentation in infertile men: a cross-sectional study
... between sperm PAH-DNA adducts and semen quality as well as sperm DNA fragmentation in adult men with non-occupational exposure to ...between sperm PAH-DNA adducts and poor semen ... See full document
7
DNA fragmentation index and its correlation with other sperm parameters in 4833 infertile males
... The total cases of male infertility in the study period were 5216, out of which those having azoospermia were 383 which were excluded. So, the sample size was 4833. A total of 4833 cases underwent routine semen analysis, ... See full document
6
Detection of 4977-bp deletion of mitochondrial DNA in in vitro fertilization failure women: A case-control study
... this deletion with many diseases has been confirmed, including the study of Gashti and his colleagues who examined the 4977-bp mutations in the semen samples of varicocele ... See full document
6
Mechanisms of Mitochondrial DNA Deletion Formation.
... features of these DNA ends. However, the break-points detected for a PstI end and the D-loop have been proposed to occur due to the relaxed three-stand confirmation of the D-loop, allowing for single strand ... See full document
23
Correlation between sperm oxidative stress and sperm DNA damage in subfertile men
... Thereafter the sample was divided into two aliquots of 100 µL. NBT 0.01% stock was prepared dissolving one NBT tablet (Sigma Aldrich, St Louis, MO, USA) in MilliQ water (Millipore Corporation, Billerica, MA, USA) and ... See full document
34
Correlation between sperm parameters and sperm DNA fragmentation in fertile and infertile men
... and sperm DNA damage. Sperm DNA damage as assessed by Comet assay demonstrated a very clear negative relationship with sperm motility and ...of sperm with DNA damage ... See full document
6
Mitochondrial DNA and Human Evolution
... the mitochondrial variation among the major populations of the world and to consider the possibility that selection contributed to the adaption of humans to changing environmental conditions such as climate change ... See full document
41
Effects of cryopreservation on mitochondrial function and DNA damage of bovine sperm
... buffalo sperm before freezing that DNA damage increased during incubation up to 24h using the SCSA ...in DNA damage of bovine sperm before cryopreservation during an incubation time of ... See full document
129
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