[PDF] Top 20 Correlation between brain volume loss and clinical and MRI outcomes in multiple sclerosis

... determined between percentage BV change (PBVC) on-study and each of 10 biologically plausible baseline predictors of BVL: NBV and the 9 parameters specified above (in the section baseline corre- ...final ... See full document

... Abstract: Multiple sclerosis (MS) has traditionally been considered to be primarily an inflammatory demyelinating disorder affecting the white ...indeed, brain atrophy is the best predictor of ... See full document

... disease. MRI is now increasingly being used as a sunogate marker of disease activity in the context of clinical ...The MRI findings in the brain are not ...poor correlation ... See full document

... Forty-nine patients (36 female and 13 male patients) with clinically definite relapsing-remitting multiple sclerosis accord- ing to the Poser criteria (27) were recruited for this study. The mean patient ... See full document

... In this article, we evaluated the impact of changing MR imaging systems on the results of brain volume quantification and assessed the robustness of 7 postprocessing algorithms. Intersite variability showed ... See full document

... standard brain imaging protocol of the clinic, with section thickness and in-plane resolutions match- ing those of the synthetic MR imaging ...1: MRI acquisition ... See full document

... of brain atrophy. Intramuscular IFN-β-1a produced lower rates of brain volume loss (BVL) when compared to pla- cebo during the second year of treatment in relapsing– remitting MS patients (− ... See full document

... relationship between neuronal metabolism and neuropsychological ...NAA. Clinical MRS studies of disease processes in which neuronal loss is a prominent pathological feature such as in stroke (Gideon ... See full document

... Multiple sclerosis (MS) in childhood and adolescence is characterized by both clinical and MRI evidence of highly active ...response. MRI forms a key component in ...on brain ... See full document

... on brain MRI in clinically isolated syndrome patients follow- ing a first clinical demyelinating event ...on Multiple Sclerosis Registry reported that the presence of vascular ... See full document

... standardised MRI data in registries, and indeed their acquisition in clinical practice, is ...strong. MRI provides evidence of disease activity in MS [46] and new T2 hyperintense and T1 hypointense ... See full document

... For each lesion, the signal intensity was measured in three regions of interest (ROI) within the same slice: 1) within the lesion, 2) in adjacent normal appearing white matter (NAWM) next to the lesion, and 3) in the ... See full document

... Axial and coronal T1-weighted (MSME; TE 10.5 ms, TR 322 ms, 0.5 mm slice thickness, matrix 256 × 256, field of view (FOV) 2.8 cm, eight averages, 40 coronal slices, scan time 22 minutes, and 20 axial slices, scan time 16 ... See full document

... This evening discussion was opened by Claire Bom- bardier (Toronto, Canada), who stressed the need to learn more about relations between radiographic signs and functional outcome and impairment of quality of life. ... See full document

... In osteoporosis, molecular mechanisms leading to bone loss are inadequately explained. There is evidence of interac- tion between bone and the immune system. T cell activity could stimulate bone loss ... See full document

... relationship between personality and health is considered highly important; each of these five factors has affected health levels (Jackson, ...relationship between the personality construct and the health ... See full document

... lapsing-remitting multiple sclerosis are likely heterogeneous in terms of both MR imaging findings and clinical events and that this heterogeneity should be taken into account for infer- ential ... See full document

... relationship between cortical brain demyelination le- sions and cognitive impairment especially in frontal lobe when compared with non-cortical ...during clinical practice radiological detec- tion of ... See full document

... homology between selected autoantibodies and a number of various antiviral IgGs, we suggest that a wide range of pathogens, rather than a single virus, are possible triggers of ... See full document

... points between onset of enhance- ment and 6 months to determine how many plaques resolve in less than 6 ...the brain characteristically undergo more rapid changes over periods of days to ...our ... See full document