[PDF] Top 20 Degradation Study of Dapagliflozin in API by Spectroscopic Method

... Dapagliflozin belongs to a new class of oral anti diabetic drugs, called Sodium Glucose Co- Transporter 2 (SLGT2) inhibitors. These sodium glucose co-transporters are responsible for glucose reabsorption in the ... See full document

... Dapagliflozin (purity 99.99%) and Saxagliptin (purity 99.99%) samples were provided by Cipla Pharmaceuticals, Mumbai. respectively. Methanol were procured from Merck, Germany. All chemicals were of analytical ... See full document

... The average of 10 Tablet was determined and grounded in mortar.An accurately weigh amount of powder equivalent to 10 mg of Perampanel was taken. It was transferred to 10 ml of volumetric flask. Add 5 ml of diluents and ... See full document

... Chemical name of sugammadex is 6A, 6B, 6C, 6D, 6E, 6F, 6G, 6H-octakis- S-(2-carboxyethyl)-6A, 6B, 6C, 6D, 6E, 6F, 6G, 6H-octathio-γ-cyclodextrin octasodium salt which is a modified γ-cyclodextrin. Cyclodextrins are ... See full document

... The degradation pathway of sitagliptin in bulk and tablet has been investigated during stress ...Major degradation products were isolated in pure form and characterized using mass and NMR ...assay ... See full document

... HPLC study, the resultant solution was diluted to 100 µg/ml solution and 10 µl was injected into the system and the chromatograms were recorded to assess the stability of sample which is shown in ...of ... See full document

... preservatives, degradation products, extractable and leachable from container and closure or manufacturing process, pesticide in drug product from plant origin and ...test method is to generate reliable and ... See full document

... through degradation of GIP [2] and the degradation of GLP-1 ...drugs. Dapagliflozin is chemically called as (1S)-1, 5-anhydro-1-C-[4- chloro-3-[(4- ethoxyphenyl) methyl] phenyl]-D-glucitol (Figure ... See full document

... Accuracy is the closeness to the true value. To study the accuracy, 10 tablets of Capecitabine were taken, and the powder was used to carry out the analysis. Recovery studies were carried out by addition of ... See full document

... The method has been developed and validated with Peak LC P7000 HPLC (Isocratic) system with 20 µl rheodyne injector and UV/Visual detectorUV7000 and PEAK chromatographic version ...Mumbai. Method was ... See full document

... proposed method was found to be simple, precise, accurate, rapid and specific for determination of Saxagliptin from pure and its dosage ...for method development is very simple to prepare and economical ... See full document

... UV spectroscopic method reported for the direct quantitative determination of ketoconazole in three pharmaceutical formulations (tablets, cream, ...UV spectroscopic method for the quantitative ... See full document

... present study, FT FT-Raman spectral investigation of TA has been performed using density functional theory ...DFT method to give clear evidence of stabilization originating from the hyper conjugation of ... See full document

... During method development it has to be ensured that no any known as well unknown impurity especially any intermediate or raw material from which the product is synthesized, should interfere with each ... See full document

... Transcendence awareness in the Api Tauhid novel can also be seen from the narrative of bismillah pronunciation. In Islam, an activity begins with reading basmalah. This is a description of the transcendence ... See full document

... this study. First, our study was conducted in a single center and the sample size was relatively ...this study is a retrospective study; thus, the medications were not controlled, and the ... See full document

... chromatographic method to remain unaffected by small deliberated variations in procedural ...this study, small deliberated changes to the chromatographic conditions were performed to investigate the ... See full document

... of Dapagliflozin were weighed individually and spiked with 1 mg Hydroxy Propyl Cellulose (E463) and 1 mg Micro Crystalline Cellulose (E460 (i)) as tablet excipients into a 100 ml volumetric ...and ... See full document

... Robustness conditions like Flow minus (0.9ml/min), Flow plus (1.1ml/min), mobile phase minus (65:35) mobile phase plus (55:45) temperature minus (25°C) and temperature plus (35°C) was maintained and samples were injected ... See full document

... B. putrificus, B. subtilis, B. cereus and B. mesentericus are important bacteria involved in degradation of keratinaceous materials like wool, animal fibers, avian feathers etc. Choudary R.B., one of the authors ... See full document