[PDF] Top 20 A Diacidic Motif in Human Immunodeficiency Virus Type 1 Nef Is a Novel Determinant of Binding to AP-2
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A Diacidic Motif in Human Immunodeficiency Virus Type 1 Nef Is a Novel Determinant of Binding to AP-2
... and AP-2 binding (6, 8, 11, 12, 17, ...1,290 Nef sequences obtained from the Los Alamos HIV sequence da- tabase showed that conservation is not limited to the dileucine motif but ... See full document
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A Basic Patch on α-Adaptin Is Required for Binding of Human Immunodeficiency Virus Type 1 Nef and Cooperative Assembly of a CD4-Nef-AP-2 Complex
... the AP-2 ␣ subunit that are required for interaction with HIV-1 ...the Nef diacidic motif must interact with basic residues on AP-2 that are not conserved in the ... See full document
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Modulation of Cellular Protein Trafficking by Human Immunodeficiency Virus Type 1 Nef: Role of the Acidic Residue in the ExxxLL Motif
... the binding of Nef to specific members of the AP complex family (Table ...of Nef with both AP-1 and ...with AP-3 but may retain an ability to interact with ...for ... See full document
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Regulation of APOBEC3 Proteins by a Novel YXXL Motif in Human Immunodeficiency Virus Type 1 Vif and Simian Immunodeficiency Virus SIVagm Vif
... FIG. 1. A conserved YXXL motif in HIV-1 Vif is important for binding and neutralization of ...stomatitis virus glycoprotein (VSVG), and wild-type or mutant ...normalized ... See full document
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Cooperative Binding of the Class I Major Histocompatibility Complex Cytoplasmic Domain and Human Immunodeficiency Virus Type 1 Nef to the Endosomal AP-1 Complex via Its μ Subunit
... motif in ...by Nef were confirmed using a flow cytometric assay in which T cells (SupT1 line) were transfected to transiently express Nef ...FIG. 1. Nef-mediated down-regulation of ... See full document
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Identification of the LWYIK Motif Located in the Human Immunodeficiency Virus Type 1 Transmembrane gp41 Protein as a Distinct Determinant for Viral Infection
... Currently, the topology between the pre-TM region and the viral envelope remains controversial, with published tomo- graphic data for SIV virions depicting conflicting models of either a “three-legged” globular stalk ... See full document
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Human Immunodeficiency Virus Type 1 Nef Expression Prevents AP-2-Mediated Internalization of the Major Histocompatibility Complex Class II-Associated Invariant Chain
... of Nef to affect MHC-II antigen presentation may impact the virus-specific T helper response and, thus, the control of the ...protein 2 (AP-2)-dependent pathway to reach the endosomes ... See full document
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Induction of AIDS in Rhesus Monkeys by a Recombinant Simian Immunodeficiency Virus Expressing nef of Human Immunodeficiency Virus Type 1
... munodeficiency virus (SIV) is one of the most widely used animal models for the study of AIDS ...A nef gene is present in all primate lentiviruses, including SIVmac and human immunodeficiency ... See full document
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Direct In Vitro Binding of Full-Length Human Immunodeficiency Virus Type 1 Nef Protein to CD4 Cytoplasmic Domain
... Human immunodeficiency virus type 1 (HIV-1) Nef is a protein containing roughly 200 amino acid ...(39). Nef has been reported to have diverse effects on cellular ... See full document
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Nef-Induced CD4 Downregulation: a Diacidic Sequence in Human Immunodeficiency Virus Type 1 Nef Does Not Function as a Protein Sorting Motif through Direct Binding to β-COP
... the Nef-induced pertur- bations of membrane trafficking was further analyzed using chimeras in which the wt or mutated Nef was fused to the extracellular and transmembrane domains of the CD8 ␣ ...of ... See full document
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Human Immunodeficiency Virus Type 1 Nef-Mediated Downregulation of CD4 Correlates with Nef Enhancement of Viral Pathogenesis
... within Nef, situated at both the amino and carboxy termini of this viral regulatory ...of Nef have been proposed to interact with the cytoplasmic tail of CD4 (28, 42, ...of Nef participate in CD4 ... See full document
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Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease.
... Virion-associated Nef is cleaved by PR. To examine whether Nef can be detected in mature HIV-1 virions, we constructed a nef-positive variant of the infectious molecular clone HXBH10, ... See full document
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Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.
... that Nef is a virion protein. Data presented herein indicate that Nef is indeed a virion ...virion-associated Nef acts in the recipient cell to increase the likelihood of successful ...of nef ... See full document
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Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
... and Nef induce CD4 endocytosis, it is likely that they act according to different ...to Nef (2, ...of Nef, it accumulates in early endosomes and is not massively targeted in late ...that ... See full document
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Human Immunodeficiency Virus Type 1 Nef Incorporation into Virions Does Not Increase Infectivity
... 63), Nef was shown to be required for opti- mal HIV and SIV infectivity in vitro and pathogenicity in vivo (4, 9, 18, 28, 37, 39, 40, 46, 47, ...by Nef to HIV-1; however, these mechanisms fail to fit ... See full document
12
Human immunodeficiency virus type 2 (HIV 2) Gag is trafficked in an AP 3 and AP 5 dependent manner
... HeLa (ATCC: CCL-2) and human embryonic kidney 293T (ATCC: CRL-11268) cells were maintained in Dulbecco ’ s modified Eagle ’ s medium supplemented with 10% fetal calf serum. Transfections were carried out ... See full document
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Activation of p21-Activated Kinase 2 by Human Immunodeficiency Virus Type 1 Nef Induces Merlin Phosphorylation
... in Nef-mediated merlin phosphorylation, we treated control and Nef-expressing CEM and U937 cells with H89 (25 M), a selective PKA inhibitor, for 5 h ...of Nef, PKA is responsible for the basal level ... See full document
5
Chimeric Human Immunodeficiency Virus Type 1 Virions That Contain the Simian Immunodeficiency Virus nef Gene Are Cyclosporin A Resistant
... the nef gene (2). This suggests that Nef has an effect on replication which is independent of CyPA incorpora- ...tion. Nef has many effects on replication and pathogenicity, and it is possible ... See full document
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Separation of Human Immunodeficiency Virus Type 1 Replication from nef-Mediated Pathogenesis in the Human Thymus
... the human thymus with similar replication ...(Table 1). They all rep- licate efficiently in PHA-activated PBMCs (40). HIV-1 repli- cation in the SCID-hu Thy/Liv model was assessed by a p24 antigen ... See full document
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Annexin 2: a Novel Human Immunodeficiency Virus Type 1 Gag Binding Protein Involved in Replication in Monocyte-Derived Macrophages
... MDM and was chosen to facilitate screening of TEM ultrathin cell sections prepared as described in the Materials and Meth- ods. The Anx2 expression level was monitored by Western blotting in parallel cultures from the ... See full document
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