[PDF] Top 20 DNA Binding Polyamides in Biological Systems
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DNA Binding Polyamides in Biological Systems
... Minor -groove binding transcription factors, such as TBP Figure 1.3, LEF-l, and TAX, have been excellent targets for polyamide inhibition, resulting in inhibition of RNA polymerase II tr[r] ... See full document
185
Localization of DNA binding polyamides in living cells
... This thesis describes work examining DNA-binding polyamides in biological systems. Chapter 2 is conceptually related to the transcription activation studies outlined as in Figure 1.9. ... See full document
37
Biological Activity of Pyrrole-Imidazole Polyamides in vivo
... factor binding elements within DNA sequences ...The binding of Py-Im PA compounds results in allosteric changes to the DNA helix that interferes with DNA-protein interactions and ... See full document
208
Improving the Biological Activity of Pyrrole-Imidazole Polyamides
... substituted polyamides (4-12) targeting the sequence 5’- WGWWCW-3’ and benchmark their DNA-binding affinities and biological activity against unsubstituted parent (1), β-amino (2), and ... See full document
211
Detection of DNA by sequence specific fluorescent polyamides
... recognize DNA take advantage of specific hydrogen bonding, van der Waals, and electrostatic interactions to sequence specifically bind to biologically important DNA ...the DNA major and minor grooves ... See full document
9
Synthesis and Biological Studies of DNA binding Cyclic Py Im Polyamides
... Pyrrole-imidazole polyamides are a class of synthetic ligands that can be programmed to bind the minor groove of specific DNA ...Py-Im polyamides can be programmed to bind a large library of ... See full document
176
Structural Variations on the Turn Unit of DNA Binding Hairpin Py Im Polyamides
... hairpin polyamides. Eight new polyamides targeting different DNA-binding motifs have been synthesized, and their impact on DNA duplex stabilization in relation to hairpins containing ... See full document
209
Endogenous Gene Regulation by DNA Binding Polyamides
... medicine. Polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) comprise a class of programmable DNA-binding ligands capable of binding to a broad repertoire of DNA ... See full document
11
Microwave synthesis, spectral characterization DNA binding studies and biological activity of Cr(III), Co(II), Ni(II), Hg(II) and Cd(II) complexes with nicotinic acid hydrazide and nitrite mixed ligand complexes
... many biological systems, especially N-donor ligand systems being a component of several vitamins and drugs such as NHA (Sallam and Abbas, ...in biological activities such as anti tubercular, ... See full document
5
Structural Modifications to DNA Binding Polyamides for Improved Biological Activity in Cell Culture
... and biological methods to control directly expression of selected endogenous genes could have broad implications for human ...of DNA binding proteins capable of sequence- specific binding (1, ... See full document
123
Structural basis of DNA duplex distortion induced by thiazole-containing hairpin polyamides
... promiscuous DNA binding profile was observed, characterized by footprints at 5’-ATTTACT, 5’- ATATACT and ...G-selective binding was observed for PA4, with PA4 exhibit- ing a clear preference for ... See full document
12
Triplex Forming Oligonucleotides – Tool for Gene Targeting
... The use of oligonucleotides to control gene expression has long fascinated researchers because of the potential to rapidly generate potent and specific agents. This review co- vers only part of oligonucleotide-based ... See full document
6
Synthesis, structural characterization, electrochemical, biological, antioxidant and nuclease activities of 3 morpholinopropyl amine mixed ligand complexes
... the binding of the Co and Ni complexes, viscosity measurements were carried out on HS DNA by varying the concentration of the added ...of binding in solution in the absence of crystallographic ... See full document
14
One-to-one motif for DNA recognition by beta-alanine-linked polyamides
... the DNA recognition ...target DNA sequence would require the ability to control the ligand ...polyamide•DNA binding mode, can be controlled by tailoring the linkage between ... See full document
178
A proteomic analysis of acute leukemia cells treated with 9-hydroxyoctadecadienoic acid
... In conclusion, 9S-HOD exerted cytotoxicity efficacy and induced apoptosis in HL-60 cells, and the cytotoxicity was largely attenuated by the presence of FBS in culture media. A classical proteomic approach is performed ... See full document
8
Probing DNA-Induced Colloidal Interactions and Dynamics with Scanning-Line Optical Tweezers
... of DNA, it is the thermodynamic stability of hybridized duplexes that is most important from the perspective of using DNA as reversible, molecular bridges be- tween particle-based ...of DNA secondary ... See full document
153
Masculine Discrepancy Stress and Health Behavior Outcomes
... narrow DNA minor groove, distamycin was found to form 2:1 antiparallel stacked dimer complexes with AT-rich DNA ...of DNA minor groove at higher affinity and specificity than traditional PAs (1, ... See full document
147
Computer Simulation of Biological Systems
... a DNA layer, using 21 base long dsDNAs sequences conjugated with a cyclic dithiol group (DTPA: ...ds- DNA solution used for cantilever functionalization has been obtained mixing two complementary strands ... See full document
160
Synthesis, molecular docking, DNA binding and biological evaluation of schiff base transition metal complexes
... and DNA interaction of metal complexes revealed that the synthesized compounds are highly ...good DNA binding property in the present study is an attempt made to evaluate their anticancer property, ... See full document
11
Spectroscopic and Electrochemical Studies on The Binding Mechanism of DNA With an Anthraquinone Biological Dye, Nuclear Fast Red
... concentration of DNA in nucleotide phosphate was determined spectrophotometrically at 260 nm using the known molar extinction coefficient value of 6600 L/mol/cm [12]. NFR was purchased from Shanghai Chemical ... See full document
12
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