[PDF] Top 20 Effect of acyclovir [9-(2-hydroxyethoxymethyl)guanine] on Epstein-Barr virus DNA replication.

... Our studies were designed to determine the effects of ACV on EBV DNA replication in the virus-producing cell line P3HR-1, in the non- virus-producing line Raji, and in latently infected [r] ... See full document

... ACV nucleotides formed in Vero, HSVinfected Vero, P3HR-1, and HSV-infected P3HR-1 cells ACV phosphorylated derivatives pmol per l0o cells Cell type Monophosphate Cell type Monophosphate [r] ... See full document

... DNA replication. We first used a PCR-based cotransfec- tion-replication assay to compare the replication function of wild-type Zta with that of the Zta mutant ...vector DNA. At 80 h ... See full document

... several DNA-protein complexes in vitro within the downstream ...of DNA replication of herpes simplex virus type 1, in which DNA- protein interactions which seem to share partially the ... See full document

... methylated DNA sequences with higher affinity than unmethylated DNA (10), and S186 contributes to this recog- nition specification ...of DNA binding (1, 6, 75, ...The DNA binding activity of ... See full document

... LCL DNA was prepared and subjected to amplification as previously described (41) with the primers 5 9 HYG IN (TCGGCACTTTGCATC) and 3 9 HYG IN (AGC GATCGCATCCAT) ...5 9 junction of SVHYG and ... See full document

... in replication complexes promoted EBV DNA replication through enzymatic activity-independent ...and DNA binding domain, was crucial for association with other viral replicating ...EBV ... See full document

... lytic replication program in the absence of any other external stimuli, allowing us to analyze precisely the architec- ture of the replication compartments of EBV lytic ...EBV replication proteins ... See full document

... cellular DNA replication ...viral replication, the EBV genome is amplified 100- to 1,000-fold by viral replication machinery composed of BALF5 DNA polymerase (Pol), BMRF1 polymerase ... See full document

... Another significant finding presented here is that LF2 in- duces covalent modification of Rta by SUMO2 and SUMO3. SUMO modification of target lysines on proteins parallels the ubiquitin pathway and consists of the ... See full document

... plasmid DNA during the first (no intercalating dye) and second (50 m g of chloroquine per ml) dimensions of ...B 9 ) In noninduced cells p562 replicates via oriP, and different plasmid forms are detected as ... See full document

... herpesvirus DNA polymerases or not (14, 38, 47, ...viral DNA and cause DNA chain termination during viral DNA ...cellular DNA poly- merase (10, ...of DNA poly- ...simplex ... See full document

... Figure 2 shows the dose-dependent effects of ACV and DHPG on viral genomes in P3HR-1 cells cultured for 14 days in the presence of drugs; EBV genome copies per cell decreased with increa[r] ... See full document

... The immediate-early class is tentatively defined as those three polypeptides formerly classified as early which show prolonged synthesis in infected cells treated with araC, araA, or MTX[r] ... See full document

... EBV replication is blocked in HPV-immortalized tonsillar epithelial rafts fol- lowing EBV ...EBV DNA levels than in HPV-neg rafts. The EBV DNA levels in HPV-neg rafts were reduced in the presence of ... See full document

... EBV replication was previously assessed using a cotransfection replication assay employing a plasmid containing oriLyt and expression vectors for replication proteins (7, 12, 13, 19, 20, ...viral ... See full document

... EBV replication in Akata cells resulted in these arrays detecting most LTIII ...the effect is perhaps more likely due to differential stability of the EBNA2/LP mRNAs, during lytic ...EBV DNA ... See full document

... primary DNA repair enzymes responsible for removal of inappropriate uracil from ...large DNA viruses may coordinate with their DNA polymerase accessory factors to enhance DNA ...of ... See full document

... Second, a 1.29-kb genomic fragment containing this region, when cloned upstream of the chloramphenicol acetyltransferase reporter gene, demonstrated promoter activity in lymphoid cells c[r] ... See full document

... We wished to learn whether activation of viral expression upon superinfection of X50-7 cells with het+ EAI+ clone 5 virus was due to the input clone 5 virus or to the endogenous virus.. [r] ... See full document