[PDF] Top 20 The effect of section thickness on MR lesion detection and quantification in multiple sclerosis

... greater lesion conspicuity of the FLAIR sequence with the higher spatial resolution and SNR per unit time possible with 3D imaging ...a section thickness of 1 mm on MR-derived lesion ... See full document

... We next investigated the quantitative measures of CMB CI and diameter to determine if these lesion characteristics influ- enced whether a CMB was prospectively counted as a lesion. We identified 65 ... See full document

... a lesion not previously seen on one of the three sequences could be identified using the information from one or both of the other two, this lesion was added to the ...a lesion at stage 1, was, on ... See full document

... for lesion quantification when semiautomated tech- niques are employed ...The detection of these small lesions is difficult, with an 18% increase in iden- tification by the second observer in this ... See full document

... To fit the model and to measure performance, we required a set of data in which the outcome is assessed by using a criterion stan- dard measure. The criterion standard was obtained using manual segmentation by an ... See full document

... Because they are acquired with a rapid ac- quisition with repeated echoes (RARE) tech- nique, fast spin-echo and fast FLAIR sequences both have the property that the brightness of structures in the images depends on ... See full document

... standard MR imaging pro- tocol used routinely at the MS clinic of ...each MR imaging of the brain performed at ...cm; section thickness, 3 mm; 2) 2D FLAIR with TE,140 ms; TR, 10 000 ms; TI, ... See full document

... Patients were scanned with a dual-echo protocol, with contiguous 3-mm-thick axial sections covering the entire brain from the foramen magnum to higher convexity (interleaved proton density weight- ed/T2 weighted, ... See full document

... studied. MR imaging was performed at 1.0 T with a quadrature receive coil. MR imaging in- cluded a cardiac-triggered sagittal long-TR dual-echo spin-echo sequence (2300/20,80/1 [TR/TE/excitations]) and a ... See full document

... decades, MR imaging has been frequently used to assess the disease burden, which is often based on the quanti- fication of the T2 lesion load (ie, the total lesion volume and/or number) on MR ... See full document

... the lesion burden (total le- sion volume) of MS patients whose scans are used for the comparison of operators' ROIs has been observed to affect an operator's or algorithm's agreement level, with an index such as ... See full document

... (r). Multiple regres- sion analysis (forward and backward stepwise methods) was used to examine which MR parameters influence T1-CR at the time of initial enhancement and after 6 months of follow-up ... See full document

... Our results suggest that 1H spectroscopy has the ability to furth er ca tegorize MR-demonstrated enha nc ing and unenhancing lesions in patients with multiple sclerosis and tha t it ma y[r] ... See full document

... Examination of the inflammatory activity of large CLs (Fig 1B) showed that MHC class II immunostaining was mainly restricted to activated microglia with ramified morphology, with a higher density in the most external ... See full document

... pericallosal multiple sclerosis plaques (Dawson fingers; ar- row) B, Axial T2 MR imaging shows a hyperintense left middle cere- bellar peduncle lesion (midline arrow) associated with a flow void ... See full document

... the detection of illegal compound (clenbuterol) was ...film thickness variations toward resonance angle shift was investigated in order to optimize the metal film effect on the sensitivity of ...film ... See full document

... new multiple sclerosis lesions demonstrate gadopentetate dimeglumine uptake, on aver- age, during a period of 1 to 2 ...of multiple sclerosis lesions could be extracted not only from ... See full document

... To reduce partial volume artifacts from anisotropic voxel size and to reduce the interpolation effects generated by resampling the second Fig 1. Subtraction of PD images from a 45-year-old male patient with MS scanned at ... See full document

... other MR tissue contrasts such as coregistered T1-weighted ...certain lesion boundary delineation in case of diffuse lesions in patients with high lesion ... See full document

... treatment effect into 2 effects (both parameters of the binomial-Weibull mix- ture are affected by treatment), the resulting sample size esti- mates are reported in tabulated form to encompass both treat- ment ... See full document