[PDF] Top 20 Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity.
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Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity.
... 5007-5012 0022-538X/91/095007-06$02.00/0 Copyright © 1991, American Society for Microbiology Effects of Changes in gpl20-CD4 Binding Affinity on Human Immunodeficiency Virus Type 1 Envel[r] ... See full document
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Mutagenic Stabilization and/or Disruption of a CD4-Bound State Reveals Distinct Conformations of the Human Immunodeficiency Virus Type 1 gp120 Envelope Glycoprotein
... of gp120, and is bounded by well-conserved residues derived from all three gp120 core el- ...of CD4, which is critical for gp120 binding, also contacts this cavity and plugs the opening ... See full document
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CD4-Induced Conformational Changes in the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein: Consequences for Virus Entry and Neutralization
... antibody binding to mutant and wild-type HIV-1 envelope glycoprotein complexes expressed on the cell surface and the ability of the 17b antibody to neutralize ...HIV-1 ... See full document
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Functional role of the V1/V2 region of human immunodeficiency virus type 1 envelope glycoprotein gp120 in infection of primary macrophages and soluble CD4 neutralization.
... Structural studies of recombinant and mutant envelope glycoproteins suggest that the function of the V1/V2 region is to interact with the V3 domain and confer on the envelope gpl20 of HI[r] ... See full document
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Antigenic Variation within the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120: Effects on Chemokine Receptor Utilization
... expressing gp120 ORFs of several molecularly cloned laboratory-adapted viruses maintain the tropism of the gp120-derived clone and demonstrate the same sensitivity to neutralizing agents as the ... See full document
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A V3 Loop-Dependent gp120 Element Disrupted by CD4 Binding Stabilizes the Human Immunodeficiency Virus Envelope Glycoprotein Trimer
... CD4 binding results in exposure of the V3 loop (49, 59), even in the context of monomeric gp120 ...of CD4-bound gp120 with an intact V3 region, the tip of the V3 loop is located ⬃ 30 Å ... See full document
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Enhancement of human immunodeficiency virus type 1 envelope-mediated fusion by a CD4-gp120 complex-specific monoclonal antibody.
... of human immunodeficiency virus type 1 (HIV-1) into cells is initiated by binding of the viral gly- coprotein gp120-gp41 to its cellular receptor ...The ... See full document
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SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement
... for 1 h at room temperature with anti-HIV-1 Env monoclonal antibodies (MAbs) recognizing the coreceptor binding site (17b), CD4-binding site gp120 epitopes (VRC03, F105, and ... See full document
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Regions required for CD4 binding in the external glycoprotein gp120 of simian immunodeficiency virus.
... SIV gp120 and map the monoclonal antibodies (MAbs) to the SU domain that inhibit CD4 ...inhibit CD4 binding, none of them maps to the V3 ...in CD4 binding by describing a hybrid ... See full document
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Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding.
... The effects of the introduced changes on the processing of the gpl60 precursor, the association of the gpl20 molecule with the gp4l glycoprotein on the expressing cell, and the ability o[r] ... See full document
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Human immunodeficiency virus type 1 envelope glycoprotein molecules containing membrane fusion-impairing mutations in the V3 region efficiently undergo soluble CD4-stimulated gp120 release.
... Plasmid pPE7H contains the HIV-1 envelope Human immunodeficiency virus type 1 HIV-1 infection is initiated by binding of the viral envelope glycoprotein to CD4 molecules on the surface o[r] ... See full document
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Human Immunodeficiency Virus (HIV) Envelope Binds to CXCR4 Independently of CD4, and Binding Can Be Enhanced by Interaction with Soluble CD4 or by HIV Envelope Deglycosylation
... for human immunodeficiency virus type 1 (HIV-1) entry (1, 6, 8, ...with CD4 and CXCR4 (18), but the nature of the binding events leading to the formation of ... See full document
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Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1.
... The binding site for gp120 is contained within the CDR2-equivalent region of CD4 D1 (1, 2, 6, 10, 33, 39, 47, ...Following binding to CD4, the spike glycoproteins of HIV undergo ... See full document
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Interaction with CD4 and Antibodies to CD4-Induced Epitopes of the Envelope gp120 from a Microglial Cell-Adapted Human Immunodeficiency Virus Type 1 Isolate
... their soluble monomeric gp120 proteins with CD4 or ...Equilibrium binding analyses showed no difference between Bori and Bori-15 ...real-time binding experiments showed that while both ... See full document
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Relationships between CD4 Independence, Neutralization Sensitivity, and Exposure of a CD4-Induced Epitope in a Human Immunodeficiency Virus Type 1 Envelope Protein
... 8x gp120 bound directly to CXCR4 and readily bound MAb 17b ...that CD4 independence was associated with stable and constitutive exposure of the coreceptor binding ...coreceptor binding site ... See full document
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CD4 Binding Site Antibodies Inhibit Human Immunodeficiency Virus gp120 Envelope Glycoprotein Interaction with CCR5
... block envelope glycoprotein-induced fusion of CD4-negative ...inhibitory effects. The inhibitory effects of Fab frag- ments in these assays contrast with the stimulatory effects ... See full document
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Envelope Conformational Changes Induced by Human Immunodeficiency Virus Type 1 Attachment Inhibitors Prevent CD4 Binding and Downstream Entry Events
... HIV CD4 attachment inhibitor ...initial gp120-CD4 interaction of viral entry and possesses potent an- tiviral activity against T- and M-tropic laboratory and clinical isolates (13, 23, ...ficiency ... See full document
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Determinants of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Activation by Soluble CD4 and Monoclonal Antibodies
... Human immunodeficiency virus type 1 (HIV-1) is the etio- logic agent of AIDS (5, 29, ...The envelope glycoproteins of HIV-1, gp120 SU and gp41 TM, are ... See full document
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Cyanovirin-N Binds to gp120 To Interfere with CD4-Dependent Human Immunodeficiency Virus Type 1 Virion Binding, Fusion, and Infectivity but Does Not Affect the CD4 Binding Site on gp120 or Soluble CD4-Induced Conformational Changes in gp120
... real-time PCR assay on an ABI Prism 7700 sequence detection system. The underlying principles and operation of this instrument are reviewed in detail elsewhere (26, 37, 61). For the present assays, the following reagent ... See full document
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Conformational changes affecting the V3 and CD4-binding domains of human immunodeficiency virus type 1 gp120 associated with env processing and with binding of ligands to these sites.
... Monoclonal antibodies MAbs that compete for binding of gpl20 to CD4 have been previously described; these include antibodies directed against linear epitopes located within the C4 domain[r] ... See full document
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