[PDF] Top 20 Efficient Activation of Viral Genomes by Levels of Herpes Simplex Virus ICP0 Insufficient To Affect Cellular Gene Expression or Cell Survival
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Efficient Activation of Viral Genomes by Levels of Herpes Simplex Virus ICP0 Insufficient To Affect Cellular Gene Expression or Cell Survival
... of ICP0 expression from AdS.11E4(ICP0) and ef- fect on transgene ...the expression of undeleted IE genes from HSV-1 IE mutant viruses is increased relative to wt ...high levels of IE ... See full document
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Induction of Cellular Stress Overcomes the Requirement of Herpes Simplex Virus Type 1 for Immediate-Early Protein ICP0 and Reactivates Expression from Quiescent Viral Genomes
... produce virus (2, 11, 12, 46, 66, 69, 75, ...cAMP levels, stimulated reactivation ...promote gene expression from a relatively large proportion of cells containing quiescent genomes, ... See full document
9
The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27.
... IE gene mutants in that it was similar to that seen in the absence of prior viral protein synthesis, possibly approximating the effect of cellular factors and virion components ...of ICP0 in ... See full document
12
Phosphorylation Site Mutations Affect Herpes Simplex Virus Type 1 ICP0 Function
... of ICP0 is a dynamic process (1, 80), the role of phos- phorylation in ICP0 function, the location of specific phos- phorylation sites on ICP0, and the kinases that phosphorylate ICP0 are ... See full document
12
Herpes Simplex Virus VP16, but Not ICP0, Is Required To Reduce Histone Occupancy and Enhance Histone Acetylation on Viral Genomes in U2OS Osteosarcoma Cells
... by ICP0 is linked to the well-documented ND10- based antiviral repression ...earliest cellular responses to HSV infection is the mobilization of ND10 com- ponents to the incoming viral genome (17, ... See full document
10
Analysis of the Functions of Herpes Simplex Virus Type 1 Regulatory Protein ICP0 That Are Critical for Lytic Infection and Derepression of Quiescent Viral Genomes
... Herpes simplex virus type 1 (HSV-1) immediate-early regulatory protein ICP0 is important for stimulating the initiation of the lytic cycle and efficient reactivation of latent or ... See full document
15
Epigenetic Modulation of Gene Expression from Quiescent Herpes Simplex Virus Genomes
... of herpes simplex virus to persist in cells depends on the extent of viral-gene expression, which may be controlled by epigenetic ...the viral mutants d109 and d106 to ... See full document
11
Requirement of the N-Terminal Activation Domain of Herpes Simplex Virus ICP4 for Viral Gene Expression
... the activation functions of ICP4, these conclusions were drawn based on two representative ...global expression patterns, protein synthesis profiles from d120-infected Vero, E5, and D14 cells were ... See full document
9
Herpes Simplex Virus Type 1 ICP0 Protein Mediates Activation of Adeno-Associated Virus Type 2 rep Gene Expression from a Latent Integrated Form
... HSV-1 gene expression during lytic infection occurs with a temporal cascade of three groups of genes: immediate- early, early, and late ...main viral transactivators re- quired for the ... See full document
10
ICP0 Is Required for Efficient Reactivation of Herpes Simplex Virus Type 1 from Neuronal Latency
... does ICP0 play in the HSV-1 reactivation pro- cess? Latency in the herpesvirus field has long been defined as the absence of infectious virus in cells or tissues that contain viral genomes, ... See full document
10
Perturbation of Cell Cycle Progression and Cellular Gene Expression as a Function of Herpes Simplex Virus ICP0
... of gene expression by ICP0 is considered to occur at the level of mRNA synthesis (44, ...75). ICP0 does not bind DNA (27), suggesting that ICP0 may activate gene ... See full document
11
PML Contributes to a Cellular Mechanism of Repression of Herpes Simplex Virus Type 1 Infection That Is Inactivated by ICP0
... HSV-1 genomes have a greatly increased probability of becom- ing repressed (11, 31, 32, ...repressed genomes are subsequently maintained in a quiescent state that could have similarities to the status of ... See full document
11
Pocket Protein p130/Rb2 Is Required for Efficient Herpes Simplex Virus Type 1 Gene Expression and Viral Replication
... PFU of HSV-1/cell. At various times p.i., cells were harvested by trypsinization and resuspended in 5 ml of 1⫻ PBS. Cells were pelleted through 1 ml of CS and then resuspended in 200 l of 1⫻ PBS with 0.2 mg of ... See full document
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Gene expression of herpes simplex virus. III. Effect of arabinosyladenine on viral polypeptide synthesis.
... Both immediate early and delayed early gene products polypeptides of classes 1 through 3 are expressed in the presence of ara-A, but there is both a 1- to 3-h delay in their reaching the[r] ... See full document
8
Expression of the Viral Thymidine Kinase Gene in Herpes Simplex Virus-Transformed L Cells
... treatment, as shown by the nearly two-fold Experiments with both synchronized and asynincrease in cell number at the end of metaphase chronous cultures strongly suggest that the viral an[r] ... See full document
10
Mutations in the major DNA-binding protein gene of herpes simplex virus type 1 result in increased levels of viral gene expression.
... We have found that at the nonpermissive temperature, the synthesis of certain immediate early, early, and late viral polypeptides was greater in cells infected with the temperature-sensi[r] ... See full document
9
Deletion of the Herpes Simplex Virus VP22-Encoding Gene (UL49) Alters the Expression, Localization, and Virion Incorporation of ICP0
... of ICP0 in either cell type infected with WT or ⌬ 22 virus ...later, ICP0 had undergone a dramatic translocation from the nucleus to the cytoplasm in both infections ...the ICP0 pattern ... See full document
11
Multimerization of ICP0, a herpes simplex virus immediate-early protein.
... To determine whether any of the transactivation-deficient IE-0 mutants that we isolated displayed a dominant negative phenotype, Vero cells were cotransfected with equimolar amounts of a[r] ... See full document
5
Activation of human papillomavirus type 18 gene expression by herpes simplex virus type 1 viral transactivators and a phorbol ester.
... A plasmid containing the HPV-18 noncoding region placed upstream of the chloramphenicol acetyltransferase reporter gene was cotransfected with different herpes simplex virus type 1 HSV-1[r] ... See full document
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Mutational analysis of the herpes simplex virus type 1 ICP0 C3HC4 zinc ring finger reveals a requirement for ICP0 in the expression of the essential alpha27 gene.
... 4°C. Cell pellets were solubilized in 300 ml (Vero) or 600 ml (293T) of ...of ICP0 was performed as previously described (54) with rabbit polyclonal antibody CLU7 ...relative levels of ICP0 ... See full document
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