[PDF] Top 20 Endoproteolytic Processing of the Ebola Virus Envelope Glycoprotein: Cleavage Is Not Required for Function
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Endoproteolytic Processing of the Ebola Virus Envelope Glycoprotein: Cleavage Is Not Required for Function
... Endoproteolytic processing is a requirement for the fuso- genic activity of many viral glycoproteins, including the HIV-1 envelope glycoprotein, the MLV envelope glycoprotein, ... See full document
8
Prototype Foamy Virus Envelope Glycoprotein Leader Peptide Processing Is Mediated by a Furin-Like Cellular Protease, but Cleavage Is Not Essential for Viral Infectivity
... precursor processing products of a PFV Env immunoadhesin molecule and the processing analysis of N glycosylation mutants revealed an LP/SU cleavage site that matches the minimal requirements of a ... See full document
6
Characterization of the Envelope Glycoprotein of a Novel Filovirus, Lloviu Virus
... is required to produce the full- length transmembrane GP is a common characteristic of viruses belonging to the genus Ebolavirus (21, ...this virus is more related to ebolaviruses than ...furin ... See full document
11
Mutational Analysis of the Putative Fusion Domain of Ebola Virus Glycoprotein
... viral envelope and cellular mem- branes is a critical event in the initiation of virus infection, identification of the fusion domain is essential for understand- ing the overall process of virus ... See full document
6
Analysis of the cleavage site of the human immunodeficiency virus type 1 glycoprotein: requirement of precursor cleavage for glycoprotein incorporation.
... Endoproteolytic cleavage of the glycoprotein precursor to the mature SU and TM proteins is an essential step in the maturation of retroviral ...glycoproteins. Cleavage of the precursor ... See full document
8
Reverse Genetics Demonstrates that Proteolytic Processing of the Ebola Virus Glycoprotein Is Not Essential for Replication in Cell Culture
... furin cleavage motif in the GP protein for Ebola virus ...GP cleavage by furin and other host cell proteases is absolutely required for their infectivity and thus determines the extent ... See full document
5
Ebola Virus Glycoprotein: Proteolytic Processing, Acylation, Cell Tropism, and Detection of Neutralizing Antibodies
... of Ebola virus GP cleavage by furin does not correlate with the level of viral infectivity conferred by this glycoprotein, suggest- ing that cleavage activation may not be ... See full document
5
Proteolytic Processing of the Human Immunodeficiency Virus Envelope Glycoprotein Precursor Decreases Conformational Flexibility
... immunodeficiency virus type ...Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi ...chimeric ... See full document
6
Endoproteolytic Processing of the Lymphocytic Choriomeningitis Virus Glycoprotein by the Subtilase SKI-1/S1P
... that cleavage is not a requirement for cell surface expression of LCMV ...Thus, endoproteolytic processing of LCMV GP is most likely not important for correct folding and cellular transport of the ... See full document
7
A cellular function is required for pseudorabies virus envelope glycoprotein processing and virus egress.
... The initial rate of viral glycoprotein synthesis was unaffected in gro29 cells, but the extent of export from the endoplasmic reticulum to the Golgi apparatus was impaired and export thr[r] ... See full document
8
Vesicular Stomatitis Virus Pseudotyped with Ebola Virus Glycoprotein Serves as a Protective, Noninfectious Vaccine against Ebola Virus Challenge in Mice
... on Ebola virus vaccines have recently been published ...filovirus glycoprotein (GP) have proven to be effective at protecting against lethal homotypic filovirus challenge in animal models ...vectors, ... See full document
13
Human immunodeficiency virus type 1 Vpu has a CD4- and an envelope glycoprotein-independent function.
... Because Vpu function was apparently not dependent on HIV-1 Env-gp expression, we wanted to determine whether the reduction in infectious virus produced by the vpu mutant could be due to [r] ... See full document
5
Extracellular cleavage of the glycoprotein precursor of Rous sarcoma virus.
... Such a situation seems to exist in murine leukemia virus, in which processing of the gag precursor P70 is performed by a proteolytic factor not identical with any known viral protein 34.[r] ... See full document
8
Mutations within the proteolytic cleavage site of the Rous sarcoma virus glycoprotein that block processing to gp85 and gp37.
... SA, although an increase in the mobility of pr95env DISCUSSION In this study, we have attempted to define the cleavage recognition sequence for the cellular protease involved in the proc[r] ... See full document
6
Sulfation of the human immunodeficiency virus envelope glycoprotein.
... Sulfated HIV-1 envelope glycoproteins were identified in H9 cells infected with the IIIB isolate of HIV-1 and in the cell lysates and culture media of cells infected with vaccinia virus [r] ... See full document
7
Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing
... for virus assembly ...project glycoprotein (GP) spikes that are synthesized and inserted into the host cell-derived envelope during budding ...transmembrane glycoprotein, is processed by a ... See full document
14
Role of Endosomal Cathepsins in Entry Mediated by the Ebola Virus Glycoprotein
... The Ebola virus glycoprotein (GP) is a class I viral fusion protein composed of a receptor binding subunit (GP1) and a fusion subunit (GP2) that are linked by a disulfide ...is required for ... See full document
5
Identification and characterization of fusion and processing domains of the human immunodeficiency virus type 2 envelope glycoprotein.
... To characterize domains of the HIV-2 envelope glycoprotein involved in membrane fusion and in proteolytic processing, we introduced single amino acid mutations into the region of the HIV[r] ... See full document
7
Functional Importance of the Coiled-Coil of the Ebola Virus Glycoprotein
... GP function, whereas those in the C-terminal helix did, suggesting that with regard to the fusion process, the C-terminal helix may be important for sta- bilizing conformation of the GP molecule for the ... See full document
8
A Study of the Ebola Virus Glycoprotein: Disruption of Host Surface Protein Function and Evasion of Immune Responses
... during Ebola infection (reviewed in ...the function of macrophages or dendritic cells; we have shown GP expression to cause rounding in macrophages ...during Ebola infection [4,11]. Finally, loss of ... See full document
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