[PDF] Top 20 Formulation and Devolopment of Floating Matrix Tablets of Lamivudine.

... Floating matrix tablets of Lamivudine were developed to prolong gastric residence time and increase its ...The tablets were prepared by direct compression technique, using polymers such ... See full document

... . Floating drug delivery systems are gaining importance in the recent days as they can overcome the limitations of the conventional controlled release dosage forms by sustaining the dosage form in the gastric ... See full document

... of tablets prepared by direct compression method by using the hydrophilic polymers such as HPMC K4M, HPMC K100M, Xanthan gum, Guar gum, Karaya gum, Sodium cmc and hydrophobic polymers ( Ethyl cellulose) ... See full document

... United States recognized as monother- apy for treatment of early PD, further pramipexole recommended as adjuvant for therapy along with L-DOPA. Dopamine ago- nists effectively reduce dyskinesias through the droping of ... See full document

... Floating drug delivery system is one of the approaches to increase the gastric residence time of the drug. The brief gastric emptying time in humans (2-3 hrs through the major absorption zone-stomach or upper part ... See full document

... Of these agents, only zidovudine (ZDV) has been proved to reduce mortality in late-stage AIDS. It reduces the incidence of opportunistic infections and possibly also the rate of progression of HIV-1 infection to AIDS. ... See full document

... Adhiparasakthi College of Pharmacy, Melmaruvathur. 21 dispersed. In fact, a matrix is defined as a well-mixed composite of one or more drugs with gelling agent i.e. hydrophilic polymers. By the sustained release ... See full document

... that floating tablets follow zero order kinetics of drug ...optimized formulation and it was found that formulation was stable for 3 months at 40 ° C/ 75 % ...The formulation was found ... See full document

... F8 formulation, MCC PH 102 was completely replaced by lactose and this modification did not show significant difference in dissolution ...F3 formulation showed floating lag time of 85 seconds and 96% ... See full document

... prepared tablets are of standard ...LET10 formulation showed the prolonged drug release up to 18 ...release matrix tablets was found to be decreased in case of all the ... See full document

... consolidates. Values of Carr’s index below 15% usually show good flow characteristics, but readings above 25% indicate poor flowability. Carr’s index was found to be between 13.79 to 31.69 that indicate good to average ... See full document

... prepared floating matrix tablets of atenolol to prolong gastric residence time and increase drug ...The tablets were prepared by direct compression technique, using polymers such as HPMC K15M, ... See full document

... with floating ability to prolong the gastric residence time of triple drug regimen (tetracycline, metronidazole, and clarithromycin) in Helicobacter pylori–associated peptic ulcers using hydroxy propyl methyl ... See full document

... process, matrix integrity, as well as floating capability, hence from the above results it can be concluded that linear relationship exists between swelling ... See full document

... the matrix to prolong drug release up to 12 ...the tablets ruptured within 3 h with more than 80% drug ...of tablets or due to insufficient binding provided ... See full document

... the floating matrix ...In Formulation F9 Drug and HPMC K100M were taken in the ratio of ...F10 formulation the drug and HPMC K100M were taken in the ratio ...F11 formulation the drug ... See full document

... quick floating. The duration of floating for all formulations was more than 24 h due to the higher viscosity grades of HPMC K4M and K100M which helps in maintaining matrix ...based matrix ... See full document

... the matrix and allows slow disintegration of the swollen ...prepared tablets of all the formulations were evaluated for precompression parameters like angle of repose, bulk and tapped density and ... See full document

... The floating system in particular has been extensively researched, mainly because the floating system does not adversely affect the motility of the GI ...The floating sustained release dosage forms ... See full document

... Tukey test were performed for dependent variables. All formulations floated within 2 min regardless of factors studied and had total floating time of more than 12 h. It was observed that both the factors had ... See full document