[PDF] Top 20 Functional interaction of constant and variable domains of human immunodeficiency virus type 1 gp120.
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Functional interaction of constant and variable domains of human immunodeficiency virus type 1 gp120.
... To examine this question further, the 308ile codon change was introduced into the original noninfectious 267gln HIV-1 proviral clone by oligonucleotide-directed mutagene- pNL4-3 wild typ[r] ... See full document
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Cooperation of the V1/V2 and V3 Domains of Human Immunodeficiency Virus Type 1 gp120 for Interaction with the CXCR4 Receptor
... Human immunodeficiency virus type 1 (HIV-1) entry is triggered by the interaction of the gp120 envelope glycoprotein with a cellular chemokine receptor, either CCR5 ... See full document
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A Mutation in the Human Immunodeficiency Virus Type 1 Gag Protein Destabilizes the Interaction of the Envelope Protein Subunits gp120 and gp41
... HIV-1 virus-cell fusion ...fusion-competent virus and functional receptors on cells ...on virus-cell interactions that result in fusion. Inoculation with wild type HIV-1 ... See full document
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Antibody-Mediated Enhancement of Human Immunodeficiency Virus Type 1 Infectivity Is Determined by the Structure of gp120 and Depends on Modulation of the gp120-CCR5 Interaction
... between gp120 and CCR5 during antibody-me- diated ...the interaction between gp120 and ...16.4 gp120 by an anti-envelope antibody modifies its infectivity in the presence of an anti-CCR-5 ... See full document
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A Functional Role for ADAM10 in Human Immunodeficiency Virus Type 1 Replication
... extracellular domains, which include a metalloprotease domain, an integrin binding domain, and a cysteine rich ...to interaction with the adhesion molecules, C-type lectins DC-SIGN and ... See full document
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Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein.
... V2 variable loops exhibit 17 and 30% of the ability of the wild-type envelope glycoproteins to support a single round of virus entry into human peripheral blood mononuclear cells and Jurkat ... See full document
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Sequence diversity of V1 and V2 domains of gp120 from human immunodeficiency virus type 1: lack of correlation with viral phenotype.
... and functional analyses, substitutions at specific amino acid residues in the V3 region have been associated with viral phe- notype and disease progression (8, 26, ...CD4 1 target ...the gp120-CD4 ... See full document
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Mapping the Determinants of the CCR5 Amino-Terminal Sulfopeptide Interaction with Soluble Human Immunodeficiency Virus Type 1 gp120-CD4 Complexes
... of gp120 comprising residues in C4 and the V3 loop ...an interaction of the V3 loop with some other region of ...additional gp120 residues that we have yet to ...the gp120 domains, the ... See full document
9
Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein.
... the gp120 epitopes occluded on the cleavage-defective gp140 gly- ...the functional relevance of this phenomenon remains to be estab- lished, these results suggest that CD4 binding can alter gp120- ... See full document
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Evidence for a functional interaction between the V1/V2 and C4 domains of human immunodeficiency virus type 1 envelope glycoprotein gp120.
... Syncytium formation induced by CH14 derivatives Clonea pHenv pHenvCH14 pHenvCH14revlC pHenvCH14/418IM pHenvCH14/LIA pHenv/4181M b Relative syncytium Description formation' Wild-type pNL4[r] ... See full document
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Fine Mapping of the Interaction of Neutralizing and Nonneutralizing Monoclonal Antibodies with the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120
... monomeric gp120 of human immunodeficiency virus type 1 to systematically identify residues important for gp120 recognition by neutralizing and nonneutralizing monoclonal ... See full document
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Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120.
... Both the linear V2 and conformation-dependent V1V2 MAbs bind well to gpl2O expressed at the surface of infected cells Table 3, suggesting that this region of the envelope is well exposed[r] ... See full document
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Immunochemical analysis of the gp120 surface glycoprotein of human immunodeficiency virus type 1: probing the structure of the C4 and V4 domains and the interaction of the C4 domain with the V3 loop.
... Two of the C4 MAbs, G3-42 and G3-299, are clearly distinguishable from the other five by their failure to react with denatured gpl20; their relatively low affinity for C4derived peptides[r] ... See full document
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Functional Chimeras of Human Immunodeficiency Virus Type 1 gp120 and Influenza A Virus (H3) Hemagglutinin
... substituting gp120 for the HA1 globular head, certain struc- tural changes will have taken place in the remaining HA1/HA2 stalk for the two domains to be ... See full document
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An Aptamer That Neutralizes R5 Strains of Human Immunodeficiency Virus Type 1 Blocks gp120-CCR5 Interaction
... of human immunodeficiency virus type 1 (HIV-1) into target cells depends on the sequential interac- tion of the surface envelope glycoprotein, gp120, with the primary ... See full document
5
Functional Domains within the Human Immunodeficiency Virus Type 2 Envelope Protein Required To Enhance Virus Production
... of virus produc- tion. First, in common with the L domains present in retroviral Gag proteins, this motif could be acting to recruit cellular proteins important for virus ...of virus release ... See full document
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Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding.
... mutant gp120 recognition by antibodies. COS-1 cells were transfected with 10 m g of pSVIIIenv DNA expressing wild-type or mutant HXBc2 envelope glycoproteins and a Tat-expressing plasmid, ...C1 ... See full document
11
Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein
... WT virus, but with a delay of 4 days ...modest virus assembly defects in the 293T overexpression system, have even more severe phe- notypes in peripheral blood mononuclear cells or T cells ... See full document
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Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding.
... HO,2 JAMES ROBINSON,3 AND JOSEPH SODROSKI 14* Received 22 January 1993/Accepted 5 April 1993 Interaction with the CD4 receptor enhances the exposure on the human immunodeficiency type 1 [r] ... See full document
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Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region.
... 12 0022-538X/92V126997-08$02.00/0 Copyright X 1992, American Society for Microbiology Relationship of the Human Immunodeficiency Virus Type 1 gpl20 Third Variable Loop to a Component of [r] ... See full document
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