[PDF] Top 20 Functional motifs of delta antigen essential for RNA binding and replication of hepatitis delta virus.
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Functional motifs of delta antigen essential for RNA binding and replication of hepatitis delta virus.
... Lanes W, M, N, and MN contain the wild-type and mutants which are mutated in the middle domain, near the N terminus, or both of the leucine repeats for the small HDAg, respectively.. Pla[r] ... See full document
8
ERK1/2-Mediated Phosphorylation of Small Hepatitis Delta Antigen at Serine 177 Enhances Hepatitis Delta Virus Antigenomic RNA Replication
... is essential for HDV double-rolling-circle ...viral RNA replication is an interesting ques- ...an essential role in HDV replication and virus packaging (2, 15, 20, 33, 40, ...HDV ... See full document
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Hepatitis Delta Antigen Mediates the Nuclear Import of Hepatitis Delta Virus RNA
... the RNA-binding motifs of HDAg (26), were constructed by replacing the SphI-StuI fragment of pGEX-Sm with the corresponding fragments from pECE-A1 and pECE-A29, respectively (26); the C termini of ... See full document
7
Transcription Factor YY1 and Its Associated Acetyltransferases CBP and p300 Interact with Hepatitis Delta Antigens and Modulate Hepatitis Delta Virus RNA Replication
... possible functional rele- vance between YY1 and B23 and, more importantly, their involvement in HDV replication since SHDAg is essential for HDV RNA replication (11, ...HDV RNA ... See full document
12
Hepatitis Delta Antigen Requires a Minimum Length of the Hepatitis Delta Virus Unbranched Rod RNA Structure for Binding
... HDV RNA, we analyzed binding to an RNA derived from the K12 gene of human herpesvirus 8 ...This RNA is similar in size (393 nt) to 395L, but is not known or predicted to form a rod-like ... See full document
9
A pseudoknot ribozyme structure is active in vivo and required for hepatitis delta virus RNA replication.
... structural motifs, ...HDV RNA rather than the full-length HDV ...the functional intermediates of HDV RNA replication, were used, the self-cleavage activity was usually not detectable in ... See full document
8
Functional domains of delta antigens and viral RNA required for RNA packaging of hepatitis delta virus.
... of delta antigens (HDAgs) in the morphogenesis of hepatitis delta virus (HDV) have been studied ...surface antigen (HBsAg) of helper hepatitis B virus, whereas the ... See full document
7
The antigen of hepatitis delta virus: examination of in vitro RNA-binding specificity.
... We found that the ability of the HDV genomic and antigenomic RNAs to fold into the rodlike structure was an essential feature for specific RNA binding, and we were able to detect a funct[r] ... See full document
6
Transcription of Hepatitis Delta Virus RNA by RNA Polymerase II
... the replication of the RNA genome of hepatitis delta virus (HDV) involves redirection of RNA polymerase II (Pol II), a host enzyme that normally uses DNA as a ...HDV RNA ... See full document
10
The Conserved Serine 177 in the Delta Antigen of Hepatitis Delta Virus Is One Putative Phosphorylation Site and Is Required for Efficient Viral RNA Replication
... HDV RNA replication, although there are other ...HDV RNA and forms the ...of virus is a ...genomic RNA and viral polymerase in an unphosphorylated manner to form a core particle ...acid ... See full document
9
Initiation of Hepatitis Delta Virus Genome Replication
... the essential role(s) of dAg-S in virus repli- cation is less ...genome replication by transfection of cells with viral cDNAs have been successful, but only when the cDNA encodes a functional ... See full document
6
RNA-binding activity of hepatitis delta antigen involves two arginine-rich motifs and is required for hepatitis delta virus RNA replication.
... To determine whether either of the ARM-like sequences was involved in RNA binding, we made a series of deletion mutants starting from the C-terminal end of the middle domain M of HDAg am[r] ... See full document
7
Hepatitis Delta Virus Antigen Is Methylated at Arginine Residues, and Methylation Regulates Subcellular Localization and RNA Replication
... Hepatitis delta virus (HDV) contains a circular RNA which encodes a single protein, hepatitis delta antigen ...an RNA-binding domain. The methylation of ... See full document
10
Hepatitis Delta Antigen Requires a Flexible Quasi-Double-Stranded RNA Structure To Bind and Condense Hepatitis Delta Virus RNA in a Ribonucleoprotein Complex
... of hepatitis delta virus (HDV) form characteristic unbranched, quasi-double- stranded RNA secondary structures in which short double-stranded helical segments are interspersed with internal ... See full document
10
Hepatitis Delta Antigen Regulates mRNA and Antigenome RNA Levels during Hepatitis Delta Virus Replication
... genome RNA and ...genome RNA to alter the HDAg:RNA ...circular RNA transfected and was saturated at about 2,200 and 10,000 molecules per cell for the 1- and ...circular RNA is the template for ... See full document
16
Arginine-Rich Motifs Are Not Required for Hepatitis Delta Virus RNA Binding Activity of the Hepatitis Delta Antigen
... Hepatitis delta virus (HDV) replication and packaging require interactions between the unbranched rodlike structure of HDV RNA and hepatitis delta antigen (HDAg), a ... See full document
10
Genotype-Specific Complementation of Hepatitis Delta Virus RNA Replication by Hepatitis Delta Antigen
... among hepatitis delta virus (HDV) isolates have focused principally on phylogenetic analysis of sequences, which vary by 30 to 40% among three genotypes and about 10 to 15% among isolates of the same ... See full document
9
Large Hepatitis Delta Antigen Is Not a Suppressor of Hepatitis Delta Virus RNA Synthesis once RNA Replication Is Established
... of replication could influ- ence HDV RNA synthesis, the amount of L-HDAg in the virion particles is not likely to inhibit the initiation of HDV replication, since antigenomic HDV RNA synthesis ... See full document
10
Transcription of Subgenomic mRNA of Hepatitis Delta Virus Requires a Modified Hepatitis Delta Antigen That Is Distinct from Antigenomic RNA Synthesis
... HDV RNA species and that acetyla- tion may enable S-HDAg to recruit the Pol II transcription complex for G-RNA transcription and mRNA transcription, whereas the S-HDAg with unmodified K72 helps its interac- ... See full document
8
Hepatitis delta virus mutant: effect on RNA editing.
... The present study was begun as an attempt to interfere with the consequences of HDV RNA editing at position 1012. We made a base change of G-A on the antigenome at the adjacent nucleotide, 1011. The expectation ... See full document
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