[PDF] Top 20 Equine Herpesvirus Type 4 UL56 and UL49.5 Proteins Downregulate Cell Surface Major Histocompatibility Complex Class I Expression Independently of Each Other
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Equine Herpesvirus Type 4 UL56 and UL49.5 Proteins Downregulate Cell Surface Major Histocompatibility Complex Class I Expression Independently of Each Other
... affect cell surface MHC-I expression during ...to downregulate surface MHC-I to levels comparable to those for parental virus in infected cells but that EHV-4 ...to ... See full document
13
Coxsackievirus B3 Proteins Directionally Complement Each Other To Downregulate Surface Major Histocompatibility Complex Class I
... MHC class I observed during infection rep- resents a synergy between two distinct viral effects which ex- hibit directional complementarity; 3A shuts off anterograde MHC trafficking by disrupting the Golgi ... See full document
13
Equus caballus Major Histocompatibility Complex Class I Is an Entry Receptor for Equine Herpesvirus Type 1
... homogeneous cell populations that were shown to be uniformly infected with ...these cell populations were amplified by PCR and then ...cDNA. Cell surface expression of this receptor was ... See full document
8
Equine Herpesvirus 1 Multiply Inserted Transmembrane Protein pUL43 Cooperates with pUL56 in Downregulation of Cell Surface Major Histocompatibility Complex Class I
... temporal class of pUL43 expression, viral DNA synthesis was chemically inhibited with PAA, which substantially inhibited the expression of pUL43 as well as the production of gM, which was used as a ... See full document
13
Major Histocompatibility Complex Class I Downregulation Induced by Equine Herpesvirus Type 1 pUL56 Is through Dynamin-Dependent Endocytosis
... rescue cell surface expression of MHC-I, suggesting that caveola-dependent endocytosis is not involved in MHC-I in- ...of surface MHC-I was remarkably attenuated when the ... See full document
14
Simian and Human Immunodeficiency Virus Nef Proteins Use Different Surfaces To Downregulate Class I Major Histocompatibility Complex Antigen Expression
... regulatory proteins that share several functions, including the ability to downregulate class I major histocompatibility complex (MHC) and CD4 expression on the ... See full document
11
Identification and Characterization of Equine Herpesvirus Type 1 pUL56 and Its Role in Virus-Induced Downregulation of Major Histocompatibility Complex Class I
... efficiently downregulate MHC-I, suggesting that phosphorylation is actually not essential for ...of surface MHC-I in NBL6 ...be cell type ...removing surface MHC-I ... See full document
10
Human Herpesvirus 7 U21 Downregulates Classical and Nonclassical Class I Major Histocompatibility Complex Molecules from the Cell Surface
... U21-expressing cell lines we describe were gen- erated using retrovirus-mediated gene transfer and selected in puromycin or another selection ...stable cell lines are quite uniform in their ... See full document
14
Human Immunodeficiency Virus Type 1 Nef Associates with Lipid Rafts To Downmodulate Cell Surface CD4 and Class I Major Histocompatibility Complex Expression and To Increase Viral Infectivity
... and class I MHC downmodulation by Nef occur through different pathways and that different regions of Nef mediate these functions and in- fectivity enhancement (27, ...for each of these func- ... See full document
12
Varicella-Zoster Virus Retains Major Histocompatibility Complex Class I Proteins in the Golgi Compartment of Infected Cells
... the other herpesviruses known to alter cell surface MHC I ...of cell surface MHC I molecules, whereas late genes were not ...required. Expression of gC was not ... See full document
11
Human Cytomegalovirus Protein pp71 Disrupts Major Histocompatibility Complex Class I Cell Surface Expression
... whether expression of the pp71 protein altered accumulation of cell surface MHC class I or ...per cell, or exposed to 100 PFU of Ad gal or ...for cell surface MHC ... See full document
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Lack of effect of mouse adenovirus type 1 infection on cell surface expression of major histocompatibility complex class I antigens.
... decreased class I MHC surface expression is not important to the ability of MAV-1 to persist and that another mechanism is ...killer cell responses compared with mice infected with ... See full document
8
Mouse Norovirus Infection Reduces the Surface Expression of Major Histocompatibility Complex Class I Proteins and Inhibits CD8+ T Cell Recognition and Activation
... the major cause of nonbacterial gastroenteritis ...A major player in the immune response against viral infections is the group of major histocompatibility complex (MHC) class ... See full document
18
Major histocompatibility complex class I-restricted cytotoxic T-lymphocyte responses in horses infected with equine herpesvirus 1.
... of equine herpesvirus 1 (EHV-1)-specific cytotoxic T-lymphocyte (CTL) activity in the horse was ...a 4-h 51 Cr release ...of equine memory CTLs and for preparation of EHV-1-infected target ... See full document
7
Downregulation of Major Histocompatibility Complex Class I Molecules by Kaposi's Sarcoma-Associated Herpesvirus K3 and K5 Proteins
... differential expression between K3 and K5 in the viral lytic cycle, or a yet-to-be-discovered, novel ...MHC class I molecules with different activities and ... See full document
10
Herpesvirus Interference with Major Histocompatibility Complex Class II-Restricted T-Cell Activation
... HLA class II-restricted T-cell ...HLA class II evasion, viral tropism should be ...HLA class II ⫹ host B cells. Likewise, HCMV infects cells that have class II constitutively expressed ... See full document
8
Human Cytomegalovirus-Encoded Immune Modulators Partner To Downregulate Major Histocompatibility Complex Class I Molecules
... The major histocompatibility complex (MHC) class I antigen presentation pathway is a major target of the ...MHC class I molecules. Here, we show that two ... See full document
9
Transcription of Preintegrated HIV-1 cDNA Modulates Cell Surface Expression of Major Histocompatibility Complex Class I via Nef
... virus type 1 (HIV-1) DNA can occur inside infected cells, yielding all classes of viral mRNA transcripts, the translation of viral proteins is very ...the proteins made is Nef, but it is unclear ... See full document
9
The Lytic Cycle of Epstein-Barr Virus Is Associated with Decreased Expression of Cell Surface Major Histocompatibility Complex Class I and Class II Molecules
... RESULTS Cell surface MHC class I expression is decreased in the lytic ...the cell surface phenotype of EBV lytic cells, we performed two-color flow cytometry assays to ... See full document
10
Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity
... decreased surface expression of MHC class I ...and other autoimmune diseases share a strong genetic association with MHC class II genes, which may in turn be linked to genes that ... See full document
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