[PDF] Top 20 HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes
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HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes
... toward CD8 ⫹ T-cell targeting as a causal mechanism behind HLA-medi- ated control (reviewed in reference 4), it has been difficult to prove this ...of targeting of the ... See full document
12
Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design
... for CD8 + T cells in HIV ...from CD8 + T cells [15–17] supports the view that this arm of immune system is applying pressure on the ...that T cells can control established ... See full document
13
Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8+ T-Cell Epitopes
... between CD8 ⴙ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a ... See full document
6
HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function
... were mediated by recognition of discrete epitopes largely in the Gag protein, and expansion of IL-21 ⴙ CD4 ⴙ T cells in acute infection resulted in lower viral set points (P ⴝ ...ⴙ T cells of ... See full document
9
HIV-specific CD8 + T cells and HIV eradication
... effective targeting of CD8 + T cells against the viral reservoir that persists in the setting of cART (Figure ...achieving HIV eradication, we do, however, draw considerable inspiration from ... See full document
10
HIV specific CD8+ T cells and HIV eradication
... effective targeting of CD8 + T cells against the viral reservoir that persists in the setting of cART (Figure ...achieving HIV eradication, we do, however, draw considerable inspiration from ... See full document
10
Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia
... ⫹ T cell killing was later masked by the infection of CD4 ⫹ T cells ...between CD8 ⫹ and CD4 ⫹ T cells in viral inhibition is even more interest- ing when one considers that the ... See full document
12
The functional CD8 T cell response to HIV becomes type specific in progressive disease
... containing CD8 T cells directed against the virus are also present dur- ing chronic infection ...few epitopes during primary HIV infection, broadens during the chronic phase ... See full document
10
CD8+ T cells specific for conserved, cross reactive Gag epitopes with strong ability to suppress HIV 1 replication
... against HIV-1 is the best hope for controlling the AIDS epidemic, but no trials has yet showed definitive effect on prevention of HIV-1 ...against HIV-1 most likely through gen- eration of ... See full document
14
Translation of HLA-HIV associations to the cellular level: HIV adapts to inflate CD8 T cell responses against Nef and HLA-adapted variant epitopes
... on specific variations can be derived from a number of observational CTL escape studies (5, 9-11), the breadth of HLA backgrounds and viral mutations examined in these studies are narrow, relative to the great ... See full document
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Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers
... immunodominant HIV-specific CD8 ⫹ T-cell responses are broadly distributed across both blood and ...of epitopes recognized may be less important for long-term immune ... See full document
12
Identification of Hexon-Specific CD4 and CD8 T-Cell Epitopes for Vaccine and Immunotherapy
... adenovirus-specific T cells may prevent and treat such infections, the T-cell immune response to the multiplicity of adenovirus serotypes and subspecies that infect humans has not been well ... See full document
9
A molecular switch in immunodominant HIV 1 specific CD8 T cell epitopes shapes differential HLA restricted escape
... both epitopes, TL9-p24 and RM9-Nef, distinct patterns of escape mutations are induced by differ- ent HLAI molecules within the B7 superfamily ...of T-cell escape and immune control through ... See full document
11
Role of IL 17 in HIV specific CD8+T cell immunity
... 5.3 Evaluation of lung specific IFN-y and IL-17 A expression by HIV-specific CDS+ T cells following novel IL-13 inhibitor vaccine: .... 46.[r] ... See full document
202
Identification of CD8 + T Cell Epitopes Against Mycobacterium tuberculosis
... The Mtb genome contains about 4,203 open reading frames, nearly half of which are categorized as ‘hypothetical proteins’ with unknown function. Although secreted proteins are generally associated with protective immune ... See full document
13
Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes
... of specific CTL responses since such longer peptides hardly induce the specific ...imal epitopes to precisely clarify the ability of HIV-1-specific CTLs to control of ... See full document
10
Shelterin Dysfunction and p16INK4a-Mediated Growth Inhibition in HIV-1-Specific CD8 T Cells
... cytotoxic T cell responses are expanded during advanced HIV-1 infection but seem unable to effectively protect the host against disease ...of HIV-1-specific T cells, we focused ... See full document
8
Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses
... viral T-cell epitopes and responses to date; however, responses against variant or subdominant epitopes may be missed using these approaches ...towards epitopes in the variable regions ... See full document
12
Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?
... why CD8 T cell epitopes of human IAV are ...universal T cell-inducing vaccines against influenza and whether the virus is likely to evolve to escape the vaccine-induced ...of ... See full document
13
Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine Containing Multiple HLA A2 HIV CD8+ Cytotoxic T-Cell Epitopes
... ab CD8 cytotoxic T lymphocytes (CTL) have an important role in preventing human immunodeficiency virus (HIV) infection and/or slowing progression to ...an HIV type 1 CTL polyepitope, or ... See full document
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