[PDF] Top 20 Horizontal gene transfer and evolution of antibiotic gene clusters

... chromosomally-located antibiotic genes diverse in found been has of a set streptomycin pathway-specific regulator, strR, been have both that already previously streptomycetes phenotypica[r] ... See full document

... Horizontal gene transfer can facilitate the adaptation of an organism to a particular ...transferred gene most likely provided a selective ...the transfer of a DHOD gene ... See full document

... and evolution of these gene families and the differences in their com- position between pathogenic and non-pathogenic strains, several bioinformatic analyses were con- ducted both among Mycobacterium and ... See full document

... enzyme evolution is that gene duplication of multi-specific enzymes, followed by narrowing of substrate specificity, is the primary mechanism by which novel enzyme families have evolved (Jensen 1976; Ohno ... See full document

... genes. Horizontal gene transfer (HGT) is a major source of phenotypic innovation and a way to facilitate niche ...conjugal transfer proteins) were putatively acquired via ...the gene ... See full document

... Protein analyses and 3D structure predictions. The presence of sig- nal peptides in primary amino acid sequences was searched for with Sig- nalP 4.1 (52). Transmembrane domain searches and hydrophobicity analyses were ... See full document

... the clusters of orthologous groups (COGs) [19] for all 54 riboso- mal proteins of the large and small ribosomal subunits on the case-by-case ...during evolution, with the extant distribu- tion of the ... See full document

... ABSTRACT Horizontal gene transfer (HGT) can have profound effects on bacterial evolution by allowing individuals to rapidly acquire adaptive traits that shape their strategies for ...via ... See full document

... allow for the uptake of plasmid DNA as well as chromosomal DNA. Because of this, it is widely accepted that natural trans- formation is a major mechanism in the evolution of microbes. However, it is still unclear ... See full document

... the evolution of prokaryotes, there is no reason to a priori dismiss the possibility that gene loss on average outweighs gene gain caused by HGT as well as duplication followed by ... See full document

... of gene loss and evolutionary rate variation is more than adequate to explain these genes: among other reasons, the alignments and bitscores are the result of screening more than 20,000 human genes, and one might ... See full document

... Network science is a powerful tool to analyze and understand such complex systems. Various mathematical models are available to analyze and quantify such systems [18–22]. In order to use networks to model the human gut ... See full document

... of horizontal gene transfer in early evolution, and reports that, under accurate replication, lower rates of HGT are ...each gene type represented in a genome, and a lower cost c for ... See full document

... Key works: Antimicrobial resistance, horizontal gene transfer, MRSP, whole genome.. 16.[r] ... See full document

... Horizontal gene transfer (HGT) plays a critical role in evolution across all domains of life with important biological and medical ...multiple gene trees and an unknown, but estimable ... See full document

... Phages also play a key role in S. aureus adaptation and evolution, and they are transferred through horizontal gene transfer. They are also involved in the induction, packaging, and ... See full document

... In fungi, the role of horizontal gene transfer in evolution, either from.. bacteria or other fungi, has been considered to be marginal.[r] ... See full document

... promoting horizontal gene transfer by trans- ...prominent antibiotic resistance vectors in natural ...lateral transfer of antibiotic resistance in unbiased com- munities of soil ... See full document

... Horizontal gene transfer (HGT) and symbiosis constitute a basis to explain the explosive evolution and dramatic adaptability to new environments shown by both prokaryotes and ... See full document

... of gene fusions was studied by phylogenetic analysis of the domains in the fused proteins and the orthologous domains that form stand-alone ...by horizontal transfer. Of the 51 examined gene ... See full document