[PDF] Top 20 Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.
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Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.
... The levels of pulse-labeled CD4 detected on the surfaces of VBNEF cells after the 30-min pulse are similar about 20% lane 0; furthermore, an increasing amount of surface CD4 can be obser[r] ... See full document
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Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T Lymphocytes
... of Nef have been demon- strated in culture, including downregulation of cell surface CD4 molecules, downregulation of cell surface major histo- compatibility complex (MHC) class I molecules, ... See full document
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Human Immunodeficiency Virus Type 1 Nef-Induced CD4 Cell Surface Downregulation Is Inhibited by Ikarugamycin
... a virus to remove its receptor from the cell surface ...receptor, CD4, from the cell ...of CD4 to the cell surface by forming a complex with CD4 that is retained in the ... See full document
5
Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.
... cellular internalization machinery by viral proteins such as Nef to promote downregu- lation of surface molecules involved in the immune ...that Nef acts both to increase the intrinsic ... See full document
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Maintenance of Nef-Mediated Modulation of Major Histocompatibility Complex Class I and CD4 after Sexual Transmission of Human Immunodeficiency Virus Type 1
... the nef coding region varied by as much as 18% between transmission pairs but exhibited substantially lower diversity within individuals and within ...the rapid diversification of a mono- or oligoclonal ... See full document
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Delayed Human Immunodeficiency Virus Type 1-Induced Apoptosis in Cells Expressing Truncated Forms of CD4
... after virus exposure (Fig. 8B) and that expression of CD4 was modulated in those cells ...of CD4 involves the formation of Env-CD4 complexes trapped within the endoplasmic reticulum (24), ... See full document
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CD4-Chemokine Receptor Hybrids in Human Immunodeficiency Virus Type 1 Infection
... wild type in their capacity to undergo SDF- 1␣-induced ...and rapid down-modulation from the cell surface of the CD4(2D) CXCR4, CD4(2D)-Sp-CXCR4, and ... See full document
14
Human Immunodeficiency Virus Type 1 Nef Protein Targets CD4 to the Multivesicular Body Pathway
... of Nef on CD4 ubiq- FIG. 3. Depletion of TSG101 inhibits Nef-induced CD4 ...to CD4, Nef, TSG101, and actin (loading control). (B) The CD4 signal intensity for each ... See full document
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Induction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetate.
... PMA-insensitive CD4 mutant in Nef-expressing ...of Nef phosphory- lation, we examined the effect of PMA-induced Nef phosphor- ylation on the downregulation of ...PMA-resistant ... See full document
5
A Basic Patch on α-Adaptin Is Required for Binding of Human Immunodeficiency Virus Type 1 Nef and Cooperative Assembly of a CD4-Nef-AP-2 Complex
... for Nef-induced CD4 ...expressing CD4, one lacking ( ⫺ ) or expressing ( ⫹ ) Nef, and one lacking or expressing either wild-type ␣ R ( ␣ R-WT) or ␣ ...anti-human ... See full document
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Lentiviral Vectors Interfering with Virus-Induced CD4 Down-Modulation Potently Block Human Immunodeficiency Virus Type 1 Replication in Primary Lymphocytes
... simian immunodeficiency virus (SIV) Nef have highlighted the importance of this protein in viral pathogene- ...in nef replicate poorly in rhesus macaques and usually do not cause AIDS ...of ... See full document
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Nef-Induced CD4 Downregulation: a Diacidic Sequence in Human Immunodeficiency Virus Type 1 Nef Does Not Function as a Protein Sorting Motif through Direct Binding to β-COP
... The Nef protein from the human immunodeficiency virus (HIV) induces CD4 cell surface downregulation by interfering with the endocytic ...HIV type 1 Nef to ... See full document
6
Human Immunodeficiency Virus Nef Induces Rapid Internalization of the T-Cell Coreceptor CD8αβ
... of Nef-mediated down- or up-regulation of cell surface molecules in retrovirally transduced SupT1 and Daudi ...control virus or wild-type or mutant HIV-1 Nef (alleles ... See full document
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Downregulation of CD4 by Human Immunodeficiency Virus Type 1 Nef Is Dependent on Clathrin and Involves Direct Interaction of Nef with the AP2 Clathrin Adaptor
... of CD4 to such pits (12, 23, ...that Nef accelerates CD4 internalization from the cell surface (2, ...HIV-1 Nef-dependent redistribution of CD4 to endosomes in HeLa ... See full document
14
CD4 Glycoprotein Degradation Induced by Human Immunodeficiency Virus Type 1 Vpu Protein Requires the Function of Proteasomes and the Ubiquitin-Conjugating Pathway
... directs CD4 into ERAD. In HIV-1-infected cells Vpu selectively induces destruction of CD4 that is trapped in the ER due to binding to gp160 (8, 10, 63, 64), while Vpu is inactive toward ... See full document
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Direct In Vitro Binding of Full-Length Human Immunodeficiency Virus Type 1 Nef Protein to CD4 Cytoplasmic Domain
... Human immunodeficiency virus type 1 (HIV-1) Nef is a protein containing roughly 200 amino acid ...(39). Nef has been reported to have diverse effects on cellular ... See full document
5
Human Immunodeficiency Virus Type 1 Vpr Protein Does Not Modulate Surface Expression of the CD4 Receptor
... reduce surface CD4, confirming a major role of this protein in the HIV-induced downmodulation of the viral re- ceptor 6, 14a, ...wild type, infection with a Vpr-defective virus ... See full document
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Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4.
... the Nef protein encoded by the known primate immunodeficiency viruses is essential for efficient virus replication, and hence pathogenesis, in the in- fected host ...of Nef in the replication ... See full document
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Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
... of CD4 with a Golgi apparatus-specific marker in T cells of nef transgenic mice ...that CD4 accumulates in early endosomes was deduced from confocal microscopic analysis showing colocalization with ... See full document
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CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef.
... The human immunodeficiency virus type 1 (HIV-1) genes vpu, env, and nef have all been implicated in modulating the levels of cell surface CD4 on infected ... See full document
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