[PDF] Top 20 Human T-Cell Leukemia Virus Type 1 Tax Shuttles between Functionally Discrete Subcellular Targets
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Human T-Cell Leukemia Virus Type 1 Tax Shuttles between Functionally Discrete Subcellular Targets
... in discrete nuclear regions ...of Tax targeting active sites of transcription. Indeed, the Tat-Tax protein overlaps nicely with the transcription factor SP1 ...the Tax-specific pattern has ... See full document
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Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles.
... of 1% sodium dodecyl sulfate (SDS) and 10 mM ...FIG. 1. Tax is found in speckled structures within the ...a Tax expression ...that Tax-specific fluorescence is excluded from the ... See full document
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Genotoxic Stress and Cellular Stress Alter the Subcellular Distribution of Human T-Cell Leukemia Virus Type 1 Tax through a CRM1-Dependent Mechanism
... the Tax NES (L200A) resulted in exclusive nuclear localization ...The Tax M33 mutant (52) contains two mutations within the Tax NES (S199A and L200S), which we predicted would eliminate NES ...the ... See full document
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Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a.
... that Tax also interacts with and activates downstream targets of cdk4 such as the pRb tumor suppres- sor or transactivates S-phase gene expression through inter- actions with transcription factors such as ... See full document
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Superoxide-Generating Nox5α Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype
... uman T-cell leukemia virus type 1 (HTLV-1) is the first hu- man oncogenic retrovirus shown to be etiologically associ- ated with adult T-cell leukemia ... See full document
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Among all human T-cell leukemia virus type 1 proteins, tax, polymerase, and envelope proteins are predicted as preferential targets for the HLA-A2-restricted cytotoxic T-cell response.
... the tax 11-19 peptide (26), and two peptides in which the anchor residues of the tax 11-19 peptide were changed for hydrophilic ones ...(Fig. 1). As expected, the tax 11-19 peptide promotes ... See full document
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Stable Ubiquitination of Human T-Cell Leukemia Virus Type 1 Tax Is Required for Proteasome Binding
... Human T-cell leukemia virus type 1 (HTLV-1) is the retrovirus responsible for adult T-cell leukemia and HTLV-1-associated ...Adult ... See full document
10
Cytoplasmic Forms of Human T-Cell Leukemia Virus Type 1 Tax Induce NF-κB Activation
... Human T-cell leukemia virus type 1 (HTLV-1) Tax targets I- k B a and I- k B b for phosphorylation, ubiquiti- nation, and proteasome-mediated ... See full document
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Analysis of p53 Inactivation in a Human T-Cell Leukemia Virus Type 1 Tax Transgenic Mouse Model
... Individual mutations inhibit p53 function in vitro. In order to examine the effects of the individual mutations on p53 trans- activation and induction of apoptosis, we recreated each mu- tation separately by PCR-based ... See full document
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CREB/ATF-Dependent Repression of Cyclin A by Human T-Cell Leukemia Virus Type 1 Tax Protein
... the human T-cell leukemia virus type 1 (HTLV-1) oncoprotein Tax is correlated with cellular transformation contributing to the development of adult ... See full document
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Ubiquitin-Specific Peptidase 20 Targets TRAF6 and Human T Cell Leukemia Virus Type 1 Tax To Negatively Regulate NF-κB Signaling
... Ubiquitinated Tax is a substrate for ...of Tax have been shown to influence its transcriptional function (5, 9, 22, 23, 25, 28, 34, 35, ...40). Tax ubiquitination has been reported to be required for ... See full document
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Mutational analysis of human T-cell leukemia virus type 2 Tax.
... the Tax-2 mutant P316-S displayed near-wt levels of transactivation of HTLV-1 LTR-CAT, HTLV-2 LTR-CAT, and HIV- k B-CAT, whereas the identical mutation in Tax-1 (44) led to failure of the ... See full document
6
Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter.
... for Tax regulation of the PCNA promoter can be envisioned. Tax could physically bind to the protein(s) in this complex, bringing it into the proximity of the PCNA promoter where it could influence ... See full document
10
Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein.
... of Tax either transiently or stably expressed, warrants further investi- ...by Tax was observed, suggesting that the major Tax-responsive elements in the VCAM-1 promoter were found ... See full document
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Human T cell leukemia virus type I Tax induces the expression of CD83 on T cells
... Human T-cell leukemia virus type-I (HTLV-I) is a human retrovirus that is etiologically associated with adult T-cell leukemia (ATL) [16] and ... See full document
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Human T-Cell Leukemia Virus Type 1 Tax Attenuates the ATM-Mediated Cellular DNA Damage Response
... association between genome instabil- ity and carcinogenesis. Infection with human T-cell leukemia vi- rus type 1 (HTLV-1), an oncogenic retrovirus, is associated ... See full document
10
Human Immunodeficiency Virus Type 1 Genome Activation Induced by Human T-Cell Leukemia Virus Type 1 Tax Protein Is through Cooperation of NF-κB and Tat
... and Tax as well as to ...mutant virus with the kB element deleted ...for virus replication. Both factors, the kB elements in the HIV-1 LTR and the activated NF-kB protein, are required for the ... See full document
6
Inactivation of tumor suppressor Dlg1 augments transformation of a T cell line induced by human T cell leukemia virus type 1 Tax protein
... both T-cell immortalization as well as the leukemogenesis, and it shows transforming activities in various systems ...CD4+ T-cells in vitro ...HTLV Type 2 (HTLV-2) is a retrovirus that is ... See full document
13
Phosphorylation of the Human T-Cell Leukemia Virus Type 1 Transactivator Tax on Adjacent Serine Residues Is Critical for Tax Activation
... Forest virus (SFV) expression system was described previously (5, ...replication-defective virus stocks for either control SFV or the SFV recombinants expressing wild-type Tax or the ... See full document
8
Effect of human T-cell leukemia virus type I tax protein on activation of the human vimentin gene.
... Analysis of the -241- to - 140-bp region: localization of an Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest a Human vimentin promoter-CAT fusion plasmids having variou[r] ... See full document
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