[PDF] Top 20 Interaction of Poly(rC) Binding Protein 2 with the 5′ Noncoding Region of Hepatitis A Virus RNA and Its Effects on Translation
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Interaction of Poly(rC) Binding Protein 2 with the 5′ Noncoding Region of Hepatitis A Virus RNA and Its Effects on Translation
... for binding of PCBP2 to PV stem-loop IV and that the binding site is located within the 59 third of the HAV ...PCBP2 interaction, since most fragments of this RNA region tested for ... See full document
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Interaction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation.
... of translation is facilitated by interactions of cellular and or viral proteins (3, 16, 22, ...in translation initiation of eukaryotic ...of translation has been the topic of intense in- ...the ... See full document
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Interactions of Viral Protein 3CD and Poly(rC) Binding Protein with the 5′ Untranslated Region of the Poliovirus Genome
... abolished binding of PCBP in vitro (7), presumably by altering the structure at the base of loop ...This interaction appears to be critical for replication, because a poliovirus RNA carrying the same ... See full document
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Poly(C)-Binding Protein 2 Interacts with Sequences Required for Viral Replication in the Hepatitis C Virus (HCV) 5′ Untranslated Region and Directs HCV RNA Replication through Circularizing the Viral Genome
... poliovirus 5 ⬘ UTR has been shown to interact with mul- tiple cellular RNA-binding ...host protein known to bind to the 5 ⬘ UTR of the poliovirus genome, regulates the switch between ... See full document
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Hepatitis C Virus Internal Ribosome Entry Site-Dependent Translation in Saccharomyces cerevisiae Is Independent of Polypyrimidine Tract-Binding Protein, Poly(rC)-Binding Protein 2, and La Protein
... Ptb protein, and HeLa cells producing soluble Pvr (46) (used as a marker) were frac- tionated on a 10% SDS-PAGE ...Ptb protein (57 kDa) was detected by using a mouse monoclonal antibody against the His6 ... See full document
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Intracellular cleavage of hepatitis C virus RNA and inhibition of viral protein translation by hammerhead ribozymes
... the effects of hammerhead ribozymes against hepatitis C virus (HCV) RNA on viral protein translation, a luciferase reporter gene vector, pCMV/T7-NCRCdelta-luc, was constructed ... See full document
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Role of the 5′-Proximal Stem-Loop Structure of the 5′ Untranslated Region in Replication and Translation of Hepatitis C Virus RNA
... positive-strand RNA viruses, the 5⬘UTR has multiple important roles in the regulation of viral RNA trans- lation and/or replication (3, 4, 10, 18, 19, 22, 45, ...the 5⬘ end of the viral ... See full document
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RNA-Binding Protein hnRNP D Modulates Internal Ribosome Entry Site-Dependent Translation of Hepatitis C Virus RNA
... canonical translation factors (eIF2, eIF3, eIF5, and eIF5B, but not eIF4E, eIF4A, or eIF4G) are used for activity ...noncanonical translation factors (PTB, La, and NSAP1) aug- ment HCV IRES-dependent ...an ... See full document
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Essential Amino Acids of the Hantaan Virus N Protein in Its Interaction with RNA
... N protein is instrumental for encapsidation of the viral RNAs for formation of the nucleocapsid and as- sembly of the ...the virus. Each of these activities requires an interaction with viral ...an ... See full document
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Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome.
... X region and its upstream variable sequence in the 3 9 -UTR of HCV RNA, was amplified by PCR and subcloned to ...HCV RNA plus an additional 13 nt of poly(T) sequence at the 3 9 ... See full document
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Attenuating mutations in the poliovirus 5' untranslated region alter its interaction with polypyrimidine tract-binding protein.
... mutant 5 * ...at 2 h postinfection ...mately 2 h postinfection ...viral RNA synthesis, suggested that SFP8 contains a primary defect in translation that results in reduced RNA ... See full document
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Host cell proteins binding to domain IV of the 5' noncoding region of poliovirus RNA.
... poliovirus 5 9 NCR. It has remained largely uncharacterized in terms of its interactions with cellular proteins and the po- tential involvement of these proteins in the translation mech- ...abrogate ... See full document
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Attenuation stem-loop lesions in the 5' noncoding region of poliovirus RNA: neuronal cell-specific translation defects.
... complex effects of attenuating mutations mapping to the IRES sequences because these viruses have neuronal cell-specific defects in translation that are even more pronounced than those of the Sabin type 1 ... See full document
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RNA-Binding Motif Protein 24 (RBM24) Is Involved in Pregenomic RNA Packaging by Mediating Interaction between Hepatitis B Virus Polymerase and the Epsilon Element
... pregenomic RNA (pgRNA)/preC RNA and ...core protein, pgRNA also serves as the template for reverse transcription and thus plays an essential role in HBV replication ...the 5=-terminal ... See full document
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An RNA-Binding Protein, hnRNP A1, and a Scaffold Protein, Septin 6, Facilitate Hepatitis C Virus Replication
... HCV RNA was further analyzed using various regions of HCV RNAs that may have important roles in ...the 5 ⬘ NTR and 3 ⬘ NTR of HCV in both polarities were generated by in vitro transcription and then ... See full document
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Poly(A)-Binding Protein Facilitates Translation of an Uncapped/Nonpolyadenylated Viral RNA by Binding to the 3′ Untranslated Region
... the 5= end? In the present study, we demonstrated that both the ARS and 3=CITE in the 3= UTR of RNA1 enhance the cap-independent translation of RCNMV ...uncapped 5= ...uncapped 5= end? In a ... See full document
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Interaction of Hepatitis C Virus Core Protein with Viral Sense RNA and Suppression of Its Translation
... HCV RNA translation in cells expressing core protein. The RNA regions responsible for specific inter- action with the core protein include the IRES of HCV, which is important for the ... See full document
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Rubella Virus Capsid Protein Interacts with Poly(A)-Binding Protein and Inhibits Translation
... on translation in primary and cultured cell lines has been examined by a number of indepen- dent laboratories (reviewed in reference ...by virus infec- tion, but given that PABP expression is regulated at ... See full document
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All Three Domains of the Hepatitis C Virus Nonstructural NS5A Protein Contribute to RNA Binding
... of RNA probes by in vitro transcription, PCR was used to amplify sequences corresponding to either the 3⬘-terminal NS5B-coding region and 3⬘ UTR of genotypes 1b (nucleotides 9136 to 9595) and 2a ... See full document
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Activity of Hexokinase Is Increased by Its Interaction with Hepatitis C Virus Protein NS5A
... viral protein was coexpressed with each enzyme in HEK293T ...the interaction between HK2 and NS5A by coimmuno- precipitation following overexpression of both proteins in HEK293T ...an interaction be- ... See full document
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