[PDF] Top 20 Interaction of Hepatitis C Virus-Like Particles and Cells: a Model System for Studying Viral Binding and Entry
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Interaction of Hepatitis C Virus-Like Particles and Cells: a Model System for Studying Viral Binding and Entry
... CD81-positive cells (HuH7, NKNT-3, and Molt-4), blocking of cellular CD81 with anti-CD81 MAb did not inhibit HCV-LP ...its binding to Molt-4 and NKNT-3 cells, but not to HuH7 ...HCV-LP binding ... See full document
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Binding of Hepatitis C Virus-Like Particles Derived from Infectious Clone H77C to Defined Human Cell Lines
... a virus cycle is the attachment of the virion to the host cell ...in virus entry into host cells. The abolition of binding by pretreatment of MOLT-4 cells with the protease ... See full document
13
Efficient trans-Encapsidation of Hepatitis C Virus RNAs into Infectious Virus-Like Particles
... the viral genome does not contain crucial cis-active elements required for ...specific binding of HCV core to the IRES modulating its activity (5, 53, ...the interaction be- tween core and these ... See full document
13
Analysis of Antigenicity and Topology of E2 Glycoprotein Present on Recombinant Hepatitis C Virus-Like Particles
... by studying the binding properties of peptide-reac- tive MAbs to native and denatured proteins (35, ...a model for human immunodeficiency virus type 1 glycoprotein, gp120, was subsequently ... See full document
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Interaction of Hepatitis C Virus Core Protein with Viral Sense RNA and Suppression of Its Translation
... the binding properties of hepatitis C virus (HCV) core protein and its viral RNA for the encapsidation, morphogenesis, and replication of HCV, the specific interaction of HCV ... See full document
8
Y-Box Binding Protein 1 Stabilizes Hepatitis C Virus NS5A via Phosphorylation-Mediated Interaction with NS5A To Regulate Viral Propagation
... pivotal viral protein involved in multiple steps in the HCV life cycle, including HCV RNA replication (14, 63), infec- tious virus production (12, 13, 15), and the recently suggested early stage of HCV RNA ... See full document
19
Hepatitis C Virus Structural Proteins Assemble into Viruslike Particles in Insect Cells
... Hepatitis C virus (HCV) is a leading cause of chronic hepatitis in the ...of viral particles in infected individuals, the inability to propagate efficiently the virus in ... See full document
10
Sulfated Homologues of Heparin Inhibit Hepatitis C Virus Entry into Mammalian Cells
... four viral epitopes overlapping the E2 HVR1 and E2-CD81 binding domains mediate HS ...HCV-HS binding requires a specific HS structure that includes N-sulfated groups and a minimum of 10 to 14 saccha- ... See full document
9
Potential cellular receptors involved in hepatitis C virus entry into cells
... into cells through receptor-mediated endocytosis ...the cells via the LDL receptor [8,9]. The binding of low density HCV particles correlated with the extent of the LDL receptor at the cell ... See full document
6
Mutagenesis of the fusion peptide-like domain of hepatitis C virus E1 glycoprotein: involvement in cell fusion and virus entry
... The entry of both HCVpp and HCVcc is mediated by E1 and E2 in a pH-dependent manner ...E2 binding to receptors on the host cell surface and receptor-mediated endocytosis, HCV enters target cells via ... See full document
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Suppression of Viral RNA Binding and the Assembly of Infectious Hepatitis C Virus Particles In Vitro by Cyclophilin Inhibitors
... RNA binding by the full-length NS5A protein in infected ...RNA binding. The lack of effect on RNA binding of BMS-790052 treatment could be due to the relative insensitivity of JFH-1 to this com- ... See full document
9
Binding Dynamics of Hepatitis C Virus' NS5A Amphipathic Peptide to Cell and Model Membranes
... whose binding is postulated to occur via extracellular glycosamino- glycans (26) rather than protein receptors in the target membrane ...immunodeficiency virus type 1 TAT (residues 47 to 57 of TAT) is such ... See full document
8
Prolactin Regulatory Element Binding Protein Is Involved in Hepatitis C Virus Replication by Interaction with NS4B
... the viral life cycle and pathogenesis by inter- acting with host proteins ...HeLa cells support only the replica- tion step in the HCV life cycle ...HeLa cells to screen for NS4B-associated host ... See full document
19
Specific Interaction between the Hepatitis C Virus NS5B RNA Polymerase and the 3′ End of the Viral RNA
... the viral RNA on the NS5B RdRp activity was not ...specific binding of the NS5B RNA polymerase or replicative complex to the 3⬘ terminus of the viral genomic ...specific binding of ... See full document
6
Role of the Asialoglycoprotein Receptor in Binding and Entry of Hepatitis C Virus Structural Proteins in Cultured Human Hepatocytes
... transfected cells expressing both subunits, two mammalian expression vectors ...3T3-L1 cells were then transfected with both constructs simultaneously using Lipofectamine-Plus according to a protocol ... See full document
14
Cell Death-Inducing DFFA-Like Effector b Is Required for Hepatitis C Virus Entry into Hepatocytes
... Huh-7.5 cells was recapitu- lated by siRNA duplexes that targeted a different region of the CIDEB mRNA ...whether viral infec- tion could be rescued in Huh-7.5/CIDEB KD cells by restoration of CIDEB ... See full document
12
The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis
... against viral infection. Via recognizing viral pathogen-associated molecular patterns (PAMPs) by pat- tern recognition receptors (PRRs), including NOD like receptors (NLRs), toll-like ... See full document
10
Hepatitis C Virus-Like Particle Morphogenesis
... Hepatitis C virus (HCV) infection is a major cause of chronic hepatitis and cirrhosis and may lead to hepatocellular ...the viral genome in 1989 (6). HCV is an enveloped RNA ... See full document
7
Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles
... the interaction between NS5A and core ...recruiting viral RNA, which is synthesized at the viral replication com- plex, to nucleocapsid formation via interaction between the NS5A ... See full document
13
Effect of Cell Polarization on Hepatitis C Virus Entry
... three viral receptors were predominantly located at the lateral cell-cell junctions in polarized cells, suggesting that this pool of receptors may be inaccessible to HCV in fully polarized ...Caco-2 ... See full document
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