[PDF] Top 20 Juxtaposition between activation and basic domains of human immunodeficiency virus type 1 Tat is required for optimal interactions between Tat and TAR.
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Juxtaposition between activation and basic domains of human immunodeficiency virus type 1 Tat is required for optimal interactions between Tat and TAR.
... Although in vitro binding studies suggested that the nine basic amino acids from positions 48 to 57 in Tat bind efficiently to the 5' bulge in the TAR RNA stem-loop, by creating several [r] ... See full document
5
Regulation of Human Immunodeficiency Virus Type 1 Gene Expression by Clade-Specific Tat Proteins
... of human immunodeficiency virus type 1 (HIV-1) strains that comprise the current global pandemic have diversified during their worldwide spread into at least 10 distinct ... See full document
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Targeting Tat Inhibitors in the Assembly of Human Immunodeficiency Virus Type 1 Transcription Complexes
... negative Tat proteins con- taining the Tat AD alone have shown relatively modest levels of inhibition (6, 19, ...ered Tat AD. The localization function provided by this tar- geting moiety ... See full document
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Cooperation between herpes simplex virus type 1-encoded ICP0 and Tat to support transcription of human immunodeficiency virus type 1 long terminal repeat in vivo can occur in the absence of the TAR binding site.
... transcriptional activation of ICP0 by Tat requires both the Cys-rich and core regions of ...by Tat re- quires the same regions that are necessary for Tat-mediated transactivation of the ... See full document
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Functional Domains of Tat Required for Efficient Human Immunodeficiency Virus Type 1 Reverse Transcription
... terminal Tat mutants to stimulate gene expression ...wild-type tat (Fig. 5B and C, lanes 9 and 10). A Tat mutant which has glycine sub- stituted for basic amino acids 50 to 57, which ... See full document
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Arginine Methylation of the Human Immunodeficiency Virus Type 1 Tat Protein by PRMT6 Negatively Affects Tat Interactions with both Cyclin T1 and the Tat Transactivation Region
... The Tat residues R52 and R53 are the targets of ...the Tat ARM, more specif- ically the 49-RKKRR-53 stretch, to participate in high-affinity binding for HIV TAR RNA ...wild-type Tat ARM ... See full document
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Inhibition of human immunodeficiency virus type 1 and type 2 Tat function by transdominant Tat protein localized to both the nucleus and cytoplasm.
... with Tat through both the core and cysteine-rich domains was identified ...that Tat interacts with several different cellular factors and that squelching may entail competition for one or more of ... See full document
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Transcriptional trans activation by human immunodeficiency virus type 1 Tat requires specific coactivators that are not basal factors.
... for Tat-mediated trans ...abolished Tat trans activation (4, 46, ...on Tat inducibility (4, 37, 38). In fact, physical interactions be- tween Tat and TATA-binding protein (TBP) ... See full document
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Human chromosome 12 is required for optimal interactions between Tat and TAR of human immunodeficiency virus type 1 in rodent cells.
... This result indicated that the defect in rodent cells is not due to a protein or proteins that interact with the activation domain of Tat; rather, the defect resides in the RNA-binding d[r] ... See full document
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Effects of human chromosome 12 on interactions between Tat and TAR of human immunodeficiency virus type 1.
... Since the loop is required for high levels of Tat trans activation in the presence of human chromosome 12 Table 1, and since we could not develop a direct binding assay between Tat and t[r] ... See full document
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Methylation of Tat by PRMT6 Regulates Human Immunodeficiency Virus Type 1 Gene Expression
... atoms. Type I PRMTs catalyze the formation of asymmetric dimethylargin- ines (aDMA), and type II PRMTs catalyze the formation of symmetric dimethylarginines ...methyltransferase 1 (CARM1) (8, 35), ... See full document
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Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein.
... To address the role of the conserved basic domain of the tat protein in the trans-activation of HIV-1 LTR-specific gene expression, we used oligonucleotidedirected mutagenesis 35 to alte[r] ... See full document
7
Cell Cycle-Regulated Transcription by the Human Immunodeficiency Virus Type 1 Tat Transactivator
... nanograms of HIV-1 LTR (Wt) or HIV-1 LTR Sp1 deletion mutant (Sp1 del) template linearized with EcoRI (41) was added to the in vitro transcription reaction mixture containing 25 g of extract. (B) Western ... See full document
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Increased spacing between Sp1 and TATAA renders human immunodeficiency virus type 1 replication defective: implication for Tat function.
... The NFKB binding sites in the human immunodeficiency virus type 1 long terminal repeat are not required for virus infectivity.. HIV-l Tat protein trails-activates transcription in vitro.[r] ... See full document
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Structural analysis of wild-type and mutant human immunodeficiency virus type 1 Tat proteins.
... These mutants, wild type in structure but reduced in activity, identify residues in the wild-type protein that may directly contact other molecules during Tat function... STRUCTURE OF HI[r] ... See full document
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Role of tumor necrosis factor alpha in activation and replication of the tat-defective human immunodeficiency virus type 1.
... Whereas in acute HIV-1 infection, Tat is the major transcriptional transactivator, the activation of the HIV-1 LTR and the latent endogenous HIV-1 provirus by different extracellular sti[r] ... See full document
6
Genetic analysis of the cofactor requirement for human immunodeficiency virus type 1 Tat function.
... As expected, analysis of the biological activity of these fusion proteins in transfected HeLa cells demonstrated that all four Tat missense mutations abrogated the ability of the Tat-Rev[r] ... See full document
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Interactions between Equine Cyclin T1, Tat, and TAR Are Disrupted by a Leucine-to-Valine Substitution Found in Human Cyclin T1
... Plasmid constructions. Plasmid target pUX-E478, which contains the EIAV long terminal repeat (LTR) linked to the chloramphenicol acetyltransferase reporter gene, and the plasmid effector pRS-E-Tat-M, which ... See full document
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Strict Control of Human Immunodeficiency Virus Type 1 Replication by a Genetic Switch: Tet for Tat
... and virus production was measured at 2 days ...support virus replication, which will eventually disturb the transient expression ...to virus production measured at day 2 (15), and the transient ... See full document
9
Critical chemical features in trans-acting-responsive RNA are required for interaction with human immunodeficiency virus type 1 Tat protein.
... Structural requirements for trans activation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by tat: importance of base pairing, loop sequence, and b[r] ... See full document
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