[PDF] Top 20 The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency.
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The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency.
... In both experiments, the decreased spontaneous reactivation rate of the LAT deletion mutant compared with the parental or rescued virus was statistically significant McKrae versus dLAT29[r] ... See full document
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ICP0 Is Required for Efficient Reactivation of Herpes Simplex Virus Type 1 from Neuronal Latency
... wild-type herpes simplex virus type 1 (HSV-1), ICP0-null mutant viruses reactivate inefficiently from explanted, latently infected mouse trigeminal ganglia ... See full document
10
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... and herpes simplex virus type 1 ...the virus can also enter a latent state in these ...The latency-associated transcript (LAT) regulates the establishment of ... See full document
16
A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... ocular herpes simplex virus type 1 (HSV-1) infection, the virus travels up axons and establishes a lifelong latent infection in neurons of the trigeminal ... See full document
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The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... The latency-associated transcript (LAT) gene the only herpes simplex virus type 1 (HSV-1) gene abundantly transcribed during neuronal ... See full document
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The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... in reactivation per ...activity from the LAT promoter, and the mutant reactivates like the wild type in vivo in this site ...less efficient in TG neurons and reactivation is ... See full document
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Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
... ABSTRACT Herpes simplex virus (HSV) latency in neurons remains poorly under- stood, and the heterogeneity of the sensory nervous system complicates mechanis- tic ...in vivo model ... See full document
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... in latency (11, 22, ...by HSV-1, HSV-2, pseudorabies virus, and bovine herpesvirus lends support to such ...on gene expression (2), it is impossible to predict a priori which ... See full document
11
Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... proteins herpes simplex virus (HSV) uses for attachment/en- ...Interestingly, latency-associated transcript (LAT), the only viral gene consistently expressed during ... See full document
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Region of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient for Wild-Type Spontaneous Reactivation Promotes Cell Survival in Tissue Culture
... of spontaneous reactivation by ...with spontaneous reactivation, additional LAT de- letion mutants were constructed and tested in the rabbit ocular latency ...wild-type ... See full document
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The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... of HSV-1 infection. Of the more than 70 genes en- coded by HSV-1, only 6 generate transcripts that are spliced to any great extent (14, 25, 45, 63, 64; reviewed in reference 28), although ... See full document
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A Herpes Simplex Virus Type 1 Mutant Expressing a Baculovirus Inhibitor of Apoptosis Gene in Place of Latency-Associated Transcript Has a Wild-Type Reactivation Phenotype in the Mouse
... the reactivation phenotype is not yet ...blocking virus-induced apoptosis in neurons, we propose two additional potential mechanisms that we feel are worthy of ...induce reactivation also lead to ... See full document
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The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... one type of posttranslational modification that can be present at specific histone amino acid residues, and acetylation of lysines 9 and 14 of histone H3 is typically enriched in transcriptionally permis- sive ... See full document
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Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism
... than HSV-2, while all of the HSV-2-based viruses spread more efficiently than HSV-1 to the sacral spinal ...extending from the paracervical ganglia to the pelvic ...extend from ... See full document
9
In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... primary transcript for ...in vivo analyses, we observed an approximately 70% decrease in the 5= exon RNA as deter- mined by qRT-PCR ...primary transcript. Previous work suggesting that the ... See full document
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Identification of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That both Inhibit Apoptosis and Enhance the Spontaneous Reactivation Phenotype
... in HSV-1 strain McKrae, deletion of LAT nucleotides 76 to 447 (StyI-StyI) in the context of the entire LAT gene (dLAT371) (13) does not reduce spontaneous ...wild-type ... See full document
6
The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... expressed from a transgene, cannot function in ...a transcript would fail to function in trans in an antisense capacity, regardless of whether it is derived from the viral or the host ...encoded ... See full document
7
Mutations in the 5' end of the herpes simplex virus type 2 latency-associated transcript (LAT) promoter affect LAT expression in vivo but not the rate of spontaneous reactivation of genital herpes.
... LAT-deleted HSV-1 ex- pressed lytic genes in a greater number of neurons in ganglia during acute infection, implying a defect in the switch from active to latent ...neurons from which ... See full document
8
Role of Dendritic Cells in Enhancement of Herpes Simplex Virus Type 1 Latency and Reactivation in Vaccinated Mice
... is associated with the upregulation of PD-1 (pro- grammed death 1, or CD279) gene ...in vivo administration of antibodies that blocks the interaction of this inhibitory receptor with ... See full document
9
Regions of the Herpes Simplex Virus Type 1 Latency-Associated Transcript That Protect Cells from Apoptosis In Vitro and Protect Neuronal Cells In Vivo
... latent virus and facilitate efficient reactivation (19, ...for HSV-1 reactivation, also triggers increased levels of corticosteroids, which promote apoptosis, it is thought that ... See full document
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