[PDF] Top 20 Mapping the transcriptional transactivation function of simian virus 40 large T antigen.
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Mapping the transcriptional transactivation function of simian virus 40 large T antigen.
... Two mutants with lesions in the DNA-binding domain that were unable to bind to SV40 DNA were completely defective for transactivation of both promoters, while a third mutant with a lesio[r] ... See full document
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Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen.
... 2014 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We generated fragments of simian virus 40 large tumor antigen T antigen by tryptic digestion and assayed them for h[r] ... See full document
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Transactivation of a Ribosomal Gene by Simian Virus 40 Large-T Antigen Requires at Least Three Activities of the Protein
... Simian virus 40 large-T antigen transactivates the ribosomal genes which are transcribed by RNA polymer- ase (pol I), as well as genes that are dependent on either pol II or pol ... See full document
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Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen.
... In this work, we have identified an antiapoptotic region of Tag which prevents apoptosis in the context of wild type WT Tag and therefore appears to function independently of se- questration of p53 by Tag. ... See full document
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Crystal Structure of the Simian Virus 40 Large T-Antigen Origin-Binding Domain
... Rho transcriptional terminator, a hexameric helicase, was recently shown to form an open-ring structure (a spiral), and the authors suggest the open ring may provide a mechanism whereby the single-stranded nucleic ... See full document
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The major transcriptional transactivation domain of simian virus 40 large T antigen associates nonconcurrently with multiple components of the transcriptional preinitiation complex.
... both transactivation and its bind- ing to these numerous transcription ...papilloma- virus type 1 E2 proteins both bind directly to TFIID and TFIIB and compete with VP16 for factors important for ... See full document
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Monoclonal antibodies as probes for a function of large T antigen during the elongation process of simian virus 40 DNA replication.
... 411 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Various monoclonal antibodies specific for simian virus 40 large tumor antigen T antigen inhibit the elongation proc[r] ... See full document
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Simian virus 40 small t antigen activates the carboxyl-terminal transforming p53-binding domain of large T antigen.
... between large T and p53 for SV40-mediated cellular transformation is firmly estab- lished (16, 23, 52, 56, 59, 73, 74), although the functional consequences of this interaction are not fully understood and ... See full document
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The zinc finger region of simian virus 40 large T antigen.
... Such a change in conformation could affect multiple independent functions, including origin binding, transformation, and the function of the active site element of the zinc finger in rep[r] ... See full document
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Efficient transcriptional activation of many simple modular promoters by simian virus 40 large T antigen.
... We used a set of promoter derivatives of the human U6 small nuclear RNA promoter containing different TATA boxes and found that wild-type large T antigen could activate transcription fro[r] ... See full document
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A novel translational regulation function for the simian virus 40 large-T antigen gene.
... small-t antigen did not play a role in causing this phenotype came from virus infection ex- periments, as shown in ...of large-T antigen than does WT SV40 ...of ... See full document
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Oligomerization and origin DNA-binding activity of simian virus 40 large T antigen.
... In contrast, studies carried out with lytic T-antigen subclasses separated by zone velocity sedimentation or phosphocellulose chromatography showed that newly synthesized 5 to 7S T antig[r] ... See full document
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Functional characterization of temperature-sensitive mutants of simian virus 40 large T antigen.
... Purified T antigens T ag were either not exposed - or exposed + to a heat shock for 10 min at 39°C, incubated in replication buffer containing plasmids with the SV40 origin of replicatio[r] ... See full document
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Identification of a region of simian virus 40 large T antigen required for cell transformation.
... However, mutants which lack origin-binding activity retain the ability to transform both primary and established cells phenotypically, indicating that It has been known for some time tha[r] ... See full document
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ATP enhances the binding of simian virus 40 large T antigen to the origin of replication.
... 12 0022-538X/87/123649-06$02.00/0 Copyright © 1987, American Society for Microbiology ATP Enhances the Binding of Simian Virus 40 Large T Antigen the Origin of Replication to SWATI PALIT[r] ... See full document
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Simian virus 40 large T antigen oligomers: analysis of electrophoresis in the absence of detergent.
... 711-716 0022-538X/85/120711-06$02.00/0 Copyright © 1985, American Society for Microbiology Simian Virus 40 Large T Antigen Oligomers: Analysis of Electrophoresis in the Absence of Deterg[r] ... See full document
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Simian virus 40 large T antigen host range domain functions in virion assembly.
... When virus-infected cell extracts are separated on 5 to 40%0 sucrose gradients, wild-type extracts show the greatest accumulation of viral late protein in the 200S-240S fractions corresp[r] ... See full document
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Replication Stress and Mitotic Dysfunction in Cells Expressing Simian Virus 40 Large T Antigen
... that simian virus 40 (SV40) large T antigen (LT) binds to the Bub1 kinase, a key regulator of the spindle checkpoint and chromosome ... See full document
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Monoclonal antibodies specific for the carboxy terminus of simian virus 40 large T antigen.
... Peptides used for immunization of mice and in characterization of antibodies Designation Amino acid sequences corresponding to Tthe of SV40 large carboxy-terminal region Lys-Thrz Hexamer[r] ... See full document
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Self-assembly of simian virus 40 large T antigen oligomers by divalent cations.
... 531-538 0022-538X/83/020531-08$02.00/0 Copyright © 1983, American Society for Microbiology Self-Assembly of Simian Virus 40 Large T Antigen Oligomers by Divalent Cations MATHIAS MONTENAR[r] ... See full document
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