[PDF] Top 20 Mendelian randomization in family data

... With regard to the selection of SNPs as instruments, we have several comments. First, we caution that in this type of study, the polymorphisms used should be justified a priori. Searching through a large number of ... See full document

... The study does have several limitations. This study used a one-time erythrocyte membrane fatty acid concentration to determine the ARA content. While using erythrocyte mem- brane, ARA percentage instead of ARA plasma ... See full document

... scRNA-seq data do not reflect true cell type proportions in intact tissues, they do provide valuable information on cell type-specific gene ...reference data, MuSiC reliably estimates cell type proportions ... See full document

... discovery data excluding the 23andMe cohort in the largest GWAS meta-analysis of educational attainment 3 (n = ...2-sample Mendelian randomization can cause bias in results; however, because of the ... See full document

... Mendelian Randomization (MR) analysis has become widely used to assess the potential causal relationship be- tween environmental risk factors and ... See full document

... using Mendelian randomization (MR), an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier ...using data from a genome- wide association ... See full document

... Recent MR results have demonstrated a causal effect of BW on risk factors for coronary artery disease (Zanetti et al., 2018) and on type 2 diabetes (Wang et al., 2016). How- ever, no study to date has employed this ... See full document

... of data from case-control studies included in BCAC, perhaps due to reverse ...BMI data from cases were used in our MR analyses, we have effectively overcome the possible influence of reverse causation in ... See full document

... Supplementary data at IJE ...board. Data on age at diagnosis, vital status, breast cancer-specific mortality, follow-up time, time be- tween diagnosis and blood draw, lymph node status, histo- logical ... See full document

... Summary data of T2DM cannot match the six SNPs (rs12051272, rs1870843, rs16861209, rs266743, rs76150 90, and rs998584) so that they needed ...summary data of exposure and ...summary data of T2DM were ... See full document

... genetic data release, and we excluded rs1570669 because it is located at the same locus as rs6013897 in the vitamin D score on chromosome 20), ex- cluding participants with diagnosed dementia from analyses (ICD-10 ... See full document

... LifeLines data and consortia data, we found no significant causal association with any of the other in- vestigated quantitative traits and diseases in the metabolic ... See full document

... using data from three different study populations (two population-based prospective studies and one clinic-based case-control study) and having validated VTE cases in each ... See full document

... GWAS data was generated by Sample Logistics and Genotyping Facilities at the Wellcome Trust Sanger Institute and LabCorp (Laboratory Corportation of America) using support from ... See full document

... Genome-wide genotyping of participants was carried out at the Centre National de G enotypage (CNG, Evry, France), using the Illumina Human660W-Quad_v1_A array (Illumina Inc., San Diego, CA). The quality control (QC) ... See full document

... data from randomised controlled trials of smoking cessa- tion in adults with diabetes found that pooled results did not provide evidence of efficacy for smoking cessation interventions in people with diabetes ... See full document

... mary data-based Mendelian randomization (SMR) method to 28 complex traits (including diseases), which have GWAS summary statistics available in the public domain, to obtain a list of genes to ... See full document

... provide data on the degree of sample overlap among GWAS datasets on exposure and outcome in our 2-sample MR ...exposure data collected in previously conducted obser- vational studies, the majority of them ... See full document

... used data on 231,020 partici- pants of self-reported European ancestry and aged ≥16 years from 22 studies from the CARTA consortium: The British 1958 Birth Cohort (1958BC), the Avon Longitudinal Study of Parents ... See full document

... delian randomization estimates are similar to the total causal effect, whereas mean multivariable Mendelian randomiza- tion estimates are similar to the direct causal effect in each scenario ... See full document