[PDF] Top 20 In Vitro Microbicidal Activity of the Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI) UC781 against NNRTI-Resistant Human Immunodeficiency Virus Type 1
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In Vitro Microbicidal Activity of the Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI) UC781 against NNRTI-Resistant Human Immunodeficiency Virus Type 1
... that UC781 may accumulate in some cel- lular compartment that enables subsequent access to infecting HIV-1 (3, ...of UC781 are similar to those of EFV and NVP, all of which have similar ... See full document
7
A Mutation in the 3′ Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Y318F) Associated with Nonnucleoside Reverse Transcriptase Inhibitor Resistance
... in vitro resistance to DLV but not other NNRTIs ...linked NNRTI mutations following the emergence of K103N mutant viruses (1), suggest- ing the presence of drug selection pressure even after the ... See full document
5
Nonnucleoside Reverse Transcriptase Inhibitor-Resistant HIV Is Stimulated by Efavirenz during Early Stages of Infection
... The reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) converts viral genomic RNA into double- stranded DNA through the process of ... See full document
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The Nonnucleoside Reverse Transcriptase Inhibitor MIV-150 in Carrageenan Gel Prevents Rectal Transmission of Simian/Human Immunodeficiency Virus Infection in Macaques
... an NNRTI resulted in the transmission or emer- gence of viral variants resistant to the drug and whether this was affected by increasing the viral ...The virus stocks were grown for a limited number ... See full document
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Mutants of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Resistant to Nonnucleoside Reverse Transcriptase Inhibitors Demonstrate Altered Rates of RNase H Cleavage That Correlate with HIV-1 Replication Fitness in Cell Culture
... H activity contribute to the modest reduction in replication fit- ness of Y181C relative to wild-type virus, in part because this mutant also demonstrates a reduction in affinity for nucleotide ... See full document
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Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
... of human immunodeficiency virus type 1 (HIV-1) infections in highly active antiretroviral therapies (HAART) can dramati- cally reduce viral load, increase levels of CD4positive ... See full document
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Characterization and Structural Analysis of Novel Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Involved in the Regulation of Resistance to Nonnucleoside Inhibitors
... In vitro experiments demonstrated the ability of I135T to abrogate the epitope-HLA binding, thus contributing to the loss of cytotoxic-T-lymphocyte responses in vivo ...and NNRTI-treated popu- ...inhibitory ... See full document
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The Nonnucleoside Reverse Transcriptase Inhibitor UC-781 Inhibits Human Immunodeficiency Virus Type 1 Infection of Human Cervical Tissue and Dissemination by Migratory Cells
... of human immunodeficiency virus remains the major route of transmission worldwide; thus, there is an urgent need for additional prevention strategies, particularly those that could be controlled by ... See full document
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Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase.
... clear cells (CBMC) were isolated by Ficoll-Hypaque centrifugation from cord blood obtained from the Department of Obstetrics, Sir Mortimer B. Davis- Jewish General Hospital. PBL cells were isolated by Ficoll-Hypaque ... See full document
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Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Target Distinct Phases of Early Reverse Transcription
... itive inhibitor of RT that can bind directly to a hydrophobic pocket within the enzyme (31), causing a conformational change that disrupts the catalytic site and blocks its DNA polymerase ...of virus ... See full document
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Cross-Linking of the Fingers Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase to Template-Primer
... Purification of HIV-1 RT. A single colony of Escherichia coli strain DH5␣ transformed with one of the plasmids mentioned above was inoculated into 750 ml of NZY medium and grown at 37°C for 12 to 14 h before ... See full document
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Hypersusceptibility to Substrate Analogs Conferred by Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... DEAE-dextran (Sigma). After incubation at 37°C for 2 to 4 h, an additional 6 ml of DMEM was added to each plate, and incubation was continued overnight. The monolayers were then washed three times with 6 ml of PBS, and ... See full document
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Human Immunodeficiency Virus Type 1 Subtype F Reverse Transcriptase Sequence and Drug Susceptibility
... susceptibility. Nonnucleoside RT inhibitors are a promising class of antiretroviral compounds for com- bined therapy because of their low toxicity, facility of use, and reasonable ...naturally resistant ... See full document
5
Construction and Characterization of a Temperature-Sensitive Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant
... the human growth hormone, this mutagenesis approach resulted in the identifi- cation of residues involved in hormone binding ...only 1 of 33 HIV-1 RT mutants was ts, and a previous report describing ... See full document
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Effects of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Reverse Transcriptase Processing, Activity, and Drug Sensitivity
... the resistant protease, reducing the infectivity de- fect, was ruled out since no increase in the virus-associated mature RT was detected by Western blotting analysis (data not ... See full document
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Combination of Drugs and Drug-Resistant Reverse Transcriptase Results in a Multiplicative Increase of Human Immunodeficiency Virus Type 1 Mutant Frequencies
... (Table 1). As indicated in Table 1, the M41L/T215Y RT led to a ...recovering virus mutants, and there was a ...observing virus mutants compared to virus repli- cation with wt ... See full document
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HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells
... HIV-1 reverse transcription is based on its interaction with p66 RT rather than its inter- action with the HIV-1 ...the reverse transcription of HIV-1 related to the nucleocytoplasmic ... See full document
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Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.
... cloned virus is due to the RT mutation and not to an effect of the vector ...Leu74Val virus, the replication kinetics of uncharacterized clinical iso- lates should be interpreted with caution due to the ... See full document
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Mutations in the Thumb Allow Human Immunodeficiency Virus Type 1 Reverse Transcriptase To Be Cleaved by Protease in Virions
... PR participates in the breakdown of the mutant RTs. To test whether PR plays a significant role in the breakdown of RT, two different concentrations of ritonavir, a potent inhibitor of PR, were added to cells ... See full document
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Studies of neutralizing monoclonal antibody to human immunodeficiency virus type 1 reverse transcriptase: antagonistic and synergistic effects in reactions performed in the presence of nucleoside and nonnucleoside inhibitors, respectively.
... polymerase activity might be due, in part at least, to a diminished ability of the antibody-RT complex to undergo the conformational changes needed for catalysis at these hot paus- ing sites, thus causing a ... See full document
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