[PDF] Top 20 Mitotic Spindle Form and Function

Mitotic Spindle Form and Function

... The step-wise assembly and separation of SPBs tells only part of the story of SPB assembly (Figure 8). The exchange of transiently expressed GFP-tagged SPB components into SPBs (Jaspersen and Winey 2004), FRAP of ... See full document

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Kuznetsova, Anastasia (2013): Transient tetraploidy as a route to chromosomal instability. Dissertation, LMU München: Fakultät für Biologie

... specifically function at the microtubule plus-ends and regulate their ...the spindle (Kufer et ...aberrant mitotic spindle formation and chromosome segregation ...in spindle pole ... See full document

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USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis

... other mitotic regulators, USP44 is not essential for cell viability or mouse embryogenesis, as Usp44-homozygous-null mice were born at Mendelian frequen- cies and were overtly ...abnormal spindle geometry ... See full document

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Effect of SP600125 on the mitotic spindle in HeLa Cells, leading to mitotic arrest, endoreduplication and apoptosis

... the mitotic spindle itself might be a target of SP600125 ef- ...whether mitotic cells treated with 20 μM SP600125 displayed many changes in tubulin ...mini spindle with shifted chromosomes, ... See full document

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Hsp72 is targeted to the mitotic spindle by Nek6 to promote K fiber assembly and mitotic progression

... attach spindle poles to ...Hsp72 function led to loss of both proteins from the mitotic spindle ...from mitotic cells with TACC3 and ch-TOG but not the spindle-associated Cep55, ... See full document

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Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes

... the function of meiotic central spindle proteins, we carried out screens for genes that interact with subito (sub) and the CPC component ...a mitotic phenotype, a screen was performed for enhancement ... See full document

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Fanconi anemia signaling network regulates the spindle assembly checkpoint

... Functional RNAi screen reveals role for FA signaling in the SAC. We gen- erated an FA siRNA library against the 15 known human FA gene products and successfully validated these siRNAs via immunoblot- ting (Supplemental ... See full document

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Microtubules in Candida albicans Hyphae Drive Nuclear Dynamics and Connect Cell Cycle Progression to Morphogenesis

... will form, (ii) are static with respect to the position of the hyphal tip ...the mitotic frame (Nop1) or spindle disassembly frame (Tub2) to align data ... See full document

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The spindle position checkpoint in budding yeast: the motherly care of MEN

... in spindle alignment by antagonizing MEN activation, has been recently impli- cated in regulating Bub2/Bfa1 activity ...precise function in the spindle position checkpoint is currently unknown, Kin4 ... See full document

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A shift from kinesin 5 dependent metaphase spindle function during preimplantation development in mouse

... metaphase spindle bipolarity becomes independent of kinesin 5 in morulae and ...prevent spindle formation in blastocysts was ...of mitotic cells possessed normal bipolar spindles in control ... See full document

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Characterization of three spindle matrix proteins, Megator, EAST and Asator, in Drosophila

... the spindle suggesting PAR may play a role in spindle function (Smith, ...the spindle in frog egg extracts and mammalian tissue culture ...maintaining spindle bipolarity which is ... See full document

143

Transient defects of mitotic spindle geometry and chromosome segregation errors

... the mitotic apparatus, and different types of kinetochore ...the spindle equator forming the metaphase plate, and the cell is said to be in ...the mitotic spindle in ...chromosomes. ... See full document

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Kalanchoe tubiflora extract inhibits cell proliferation by affecting the mitotic apparatus

... Centrosomes increase both in size and in microtubule- capacity in late G2 phase of the cell cycle. Aurora A, by recruiting pericentriolar material (PCM) and interacting with the Ran-TPX2 pathway, is required for the ... See full document

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Monitoring spindle orientation: Spindle position checkpoint in charge

... active form) associates with the SPBs independently of Bfa1-Bub2 in late anaphase [10,99] and mitotic exit occurs without any delay in BUB2 and/or BFA1 deleted cells [10,73], we can assume that it is the ... See full document

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Rapid removal of TACC3–ch-TOG–clathrin from kinetochore fibres during mitosis

... in spindle organisation poses a clear link to tumour aneuploidy and genetic instability (Conte et ...the mitotic functions of clathrin (Blixt and Royle, ... See full document

229

Microtubule organization within mitotic spindles revealed by serial block face scanning electron microscopy and image analysis

... real mitotic spindles, the angles deviate considerably from the ...idealized spindle indicate a departure from perfect ...the spindle and examine changes in the amount of MT ...mutated form ... See full document

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Two XMAP215/TOG Microtubule Polymerases, Alp14 and Dis1, Play Non-exchangeable, Distinct Roles in Microtubule Organisation in Fission Yeast

... the mitotic spindle and movement towards the kinetochore as spindles elongate and capture it ...the mitotic spindle only at a later mitotic stage; importantly, Dis1 is not localised to ... See full document

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Dual mechanism controls asymmetric spindle position in ascidian germ cell precursors

... lateral spindle pole towards the site of cell-cell contact was the result of ...1. Spindle orientation from the 8- to 64-cell stage in P ...the mitotic spindle in two ...the mitotic ... See full document

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Dissection of the mitotic and nuclear functions of Chromator, a nuclear derived spindle matrix component in Drosophila

... for mitotic regulators some unexpected factors have been identified, which change the traditional view of the organization of a functional mitotic ...a spindle assembly factor from a screen based on ... See full document

153

The NIMA Kinase Is Required To Execute Stage-Specific Mitotic Functions after Initiation of Mitosis

... NIMA function have defects in forming a bipolar ...the spindle pole body at the nuclear periphery during inter- ...At mitotic entry, nuclear spindle microtubules are initially formed from ... See full document

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